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FBXO3

  • Official Full Name

    F-box protein 3

  • Overview

    This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants diverging at the 3 end.
  • Synonyms

    FBXO3; F-box protein 3; F box only protein 3; F-box only protein 3; FBA; FBX3; F box protein 3; F box protein FBX3; F-box protein FBX3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FBXO3-3929H Recombinant Human FBXO3 Protein, GST-tagged Wheat Germ GST
Human FBXO3-12794H Recombinant Human FBXO3, His-tagged E.coli His 124-471a.a.
Human FBXO3-6300HCL Recombinant Human FBXO3 293 Cell Lysate HEK293 N/A
Human FBXO3-5031HF Recombinant Full Length Human FBXO3 Protein, GST-tagged In Vitro Cell Free System GST 471 amino acids
Human FBXO3-1731H Recombinant Human FBXO3 Protein (1-471 aa), His-tagged Yeast His 1-471 aa
Human FBXO3-897H Recombinant Human FBXO3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human FBXO3-2395H Recombinant Human FBXO3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FBXO3-1461HFL Recombinant Full Length Human FBXO3 Protein, C-Flag-tagged Mammalian cells Flag
Human FBXO3-897H-B Recombinant Human FBXO3 Protein Pre-coupled Magnetic Beads HEK293
Human FBXO3-3474H Recombinant Human FBXO3 Protein (Val155-Phe471), N-His tagged E.coli N-His Val155-Phe471
Mouse Fbxo3-1471M Recombinant Mouse Fbxo3 Protein, His&GST-tagged E.coli N-His&GST Leu159-Phe480
Mouse Fbxo3-2966M Recombinant Mouse Fbxo3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat FBXO3-2292R Recombinant Rat FBXO3 Protein Mammalian Cell His
Rat FBXO3-1949R Recombinant Rat FBXO3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat FBXO3-1949R-B Recombinant Rat FBXO3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque FBXO3-1660R Recombinant Rhesus monkey FBXO3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque FBXO3-1484R-B Recombinant Rhesus Macaque FBXO3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque FBXO3-1484R Recombinant Rhesus Macaque FBXO3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish FBXO3-2862Z Recombinant Zebrafish FBXO3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FBXO3 Related Articles
  • FBXO3 Related Research Area

FBXO3 involved in several pathways and played different roles in them. We selected most pathways FBXO3 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &amp, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXO3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemDCTN2;PDPK1A;CLEC2G;TREML4;LAIR2;ASB7;CTSK;UBE2U;TRAT1
Antigen processing: Ubiquitination &ampASB18;UBE2F;NPEPPS;ASB10;GAN;TRAF7;UBE2L6;FBXO27;HECTD3
Proteasome degradationPJA1;TRAF7;HECTD3;ASB17;ASB3;KLHL21;UBE2E3;FBXO44;TRIM39
Class I MHC mediated antigen processing &ampRNF123;GAN;ARIH2;ERAP2;SPSB2;MKRN1;RNF182;RNF34;FCGR1B
presentationDTX3L;TRIM9;KLHL21;UBE2L6;RNF19B;TRIM11;B2ML;WSB1;HECTD3
Immune SystemCD200R2;LILRB5;NOD1;MKRN1;ARIH1;ASB11;KIF20A;TRIM45;TXNIPB

FBXO3 has several biochemical functions, for example, protein binding, ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXO3 itself. We selected most functions FBXO3 had, and list some proteins which have the same functions with FBXO3. You can find most of the proteins on our site.

Function Related Protein
protein bindingDGKQ;AGO3;PPIG;PRAP1;GLP1R;OCRL;APOOL;UBE2D2;SMC3
ubiquitin-protein transferase activityFBXW11;HACE1;TRIM28;FBXO40.1;MARCH2;FBXL5;RNF187;UBE2D2A;ARIH2

FBXO3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXO3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXO3.

SKP1; tat; HSP90AB1; TNIP3; q99ib8-pro_0000045599; NSS

Kainulainen, M; Habjan, M; et al. Virulence Factor NSs of Rift Valley Fever Virus Recruits the F-Box Protein FBXO3 To Degrade Subunit p62 of General Transcription Factor TFIIH. JOURNAL OF VIROLOGY 88:3464-3473(2014).
Mallampalli, RK; Coon, TA; et al. Targeting F Box Protein Fbxo3 To Control Cytokine-Driven Inflammation. JOURNAL OF IMMUNOLOGY 191:5247-5255(2013).
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