fdft1
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  • Official Full Name
  • farnesyl-diphosphate farnesyltransferase 1
  • Background
  • This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene.
  • Synonyms
  • FDFT1; farnesyl-diphosphate farnesyltransferase 1; squalene synthase; squalene synthetase; FPP:FPP farnesyltransferase; presqualene-di-diphosphate synthase; SS; SQS; DGPT; ERG9
Cat.#:FDFT1-4057HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FDFT1 Protein, GST-tagged
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Cat.#:FDFT1-1829HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FDFT1 protein, His-tagged
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Cat.#:FDFT1-27574THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human FDFT1
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Cat.#:Fdft1-1830MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Fdft1 protein, His-tagged
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Cat.#:FDFT1-5803MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FDFT1 Protein
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Cat.#:Fdft1-1831RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Fdft1 protein, His-tagged
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Cat.#:FDFT1-2308RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FDFT1 Protein
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Cat.#:FDFT1-1683RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey FDFT1 Protein, His-tagged
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Cat.#:FDFT1-3354CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FDFT1
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Cat.#:FDFT1-7996ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FDFT1
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Cat.#:FDFT1-6271HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human FDFT1 293 Cell Lysate
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Involved Pathway

FDFT1 involved in several pathways and played different roles in them. We selected most pathways FDFT1 participated on our site, such as Steroid biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with FDFT1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Steroid biosynthesis
HSD17B7; DHCR24; MSMO1; SC5D; CYP51; CPN1; SOAT1; TM7SF2; CYP2R1; CELL
Metabolic pathways
PTDSS1; AOC1; CKMT1; SARDH; ACSL4B; SDHDA; ACO1; GGT7; INPP5J; NDUFA6

Protein Function

FDFT1 has several biochemical functions, for example, farnesyl-diphosphate farnesyltransferase activity, oxidoreductase activity, squalene synthase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FDFT1 itself. We selected most functions FDFT1 had, and list some proteins which have the same functions with FDFT1. You can find most of the proteins on our site.
Function
Related Protein
Function farnesyl-diphosphate farnesyltransferase activity
Related Protein FDFT1
Function oxidoreductase activity
Related Protein TDH; HEPHL1A; FAM84B; OXNAD1; PCYOX1L; CYP2C38; CYP4V8; CYP2AA1; P4HA1A; CYP1A2
Function squalene synthase activity
Related Protein FDFT1

Interacting Protein

FDFT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FDFT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FDFT1.
PSTPIP1; SMNDC1; C1orf168; RUVBL1; ANXA5; ITGB5; SHPRH; ARL6IP1; TMEM43; RUVBL2; 15-deoxy-delta(12,14; FN1; 1C; HDAC10