fga
Share
  • Official Full Name
  • fibrinogen alpha chain
  • Background
  • The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus.
  • Synonyms
  • Fibrinogen; FGA; FGA protein; FGB; FGG; Fib2; Fibrinogen A alpha polypeptide; Fibrinogen A alpha polypeptide chain; Fibrinogen alpha chain; Fibrinogen B alpha polypeptide; Fibrinogen beta chain; Fibrinogen G alpha polypeptide; Fibrinogen gamma chain; MGC104327; MGC119422; MGC119423; MGC119425; MGC120405
Cat.#:FGA-4087HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FGA Protein, GST-tagged
+Inquiry
Cat.#:FGA-206HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human FGA
+Inquiry
Cat.#:FGA-36HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGA protein, His-tagged
+Inquiry
Cat.#:Fga-1545MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Fga protein, His-tagged
+Inquiry
Cat.#:Fga-1546MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Fga protein, His & T7-tagged
+Inquiry
Cat.#:FGA-5830MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FGA Protein
+Inquiry
Cat.#:Fga-1547RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Fga protein, His-tagged
+Inquiry
Cat.#:Fga-1548RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Fga protein, His-tagged
+Inquiry
Cat.#:FGA-6908CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FGA
+Inquiry
Cat.#:FGA-7799ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FGA
+Inquiry
Cat.#:FGA-1544CTag:His/T7
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle FGA protein, His & T7-tagged
+Inquiry
Cat.#:FGA-5HTag:N/A
Source (Host):Species:Human
Product nameNative Human Fibrinogen, FITC Labeled
+Inquiry
Cat.#:FGA-78HTag:
Source (Host):Species:Human
Product nameNative Human Fibrinogen (Pg & vWF depleted)
+Inquiry
Cat.#:FGA-79HTag:
Source (Host):Species:Human
Product nameNative Human Fibrinogen
+Inquiry
Cat.#:FGA-80HTag:
Source (Host):Species:Human
Product nameNative Human Fibrinogen (plasminogen depleted)
+Inquiry
Cat.#:Fga-299MTag:
Source (Host):Species:Mouse
Product nameNative Mouse Fibrinogen
+Inquiry
Cat.#:Fga -67RTag:N/A
Source (Host):Species:Rat
Product nameNative Rat Fibrinogen
+Inquiry
Cat.#:Fga-63RTag:N/A
Source (Host):Species:Rat
Product nameNative Rat Fibrinogen, FITC Labeled
+Inquiry
Cat.#:FGA-34DTag:N/A
Source (Host):Species:Dog
Product nameNative Canine Fibrinogen
+Inquiry
Cat.#:FGA-42DTag:N/A
Source (Host):Species:Dog
Product nameNative Canine Fibrinogen, FITC Labeled
+Inquiry
Cat.#:FGA-30BTag:N/A
Source (Host):Species:Bovine
Product nameNative Bovine Fibrinogen
+Inquiry
Cat.#:FGA-39BTag:N/A
Source (Host):Species:Bovine
Product nameNative Bovin Fibrinogen, FITC Labeled
+Inquiry
Cat.#:FGA-55RTag:N/A
Source (Host):Species:Rabbit
Product nameNative Rabbit Fibrinogen, FITC Labeled
+Inquiry
Cat.#:FGA-58RTag:N/A
Source (Host):Species:Rabbit
Product nameNative Rabbit Fibrinogen
+Inquiry
Cat.#:FGA-618HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human FGA cell lysate
+Inquiry

Involved Pathway

FGA involved in several pathways and played different roles in them. We selected most pathways FGA participated on our site, such as Complement and coagulation cascades, Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Complement and coagulation cascades
F13A1; F11; FGA; C4BPA; C8A; F2R; PLG; CFD; SERPINA5; CR2
Platelet activation
F2R; PLCB4; LYN; PIK3CD; GP1BB; GNAQ; VWF; PRKCZ; ITGB3; FGA

Protein Function

FGA has several biochemical functions, for example, contributes_to cell adhesion molecule binding, protein binding, protein binding, bridging. Some of the functions are cooperated with other proteins, some of the functions could acted by FGA itself. We selected most functions FGA had, and list some proteins which have the same functions with FGA. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to cell adhesion molecule binding
Related Protein FGB; FGA
Function protein binding
Related Protein EFCAB4B; DAK; TRAPPC5; SPRED1; SYMPK; CCPG1; BID; FGFR1; PTK2B; BOK
Function protein binding, bridging
Related Protein FGB; ST13; RBM14; IVL; COL8A2; NCK1; ADAP2; DDX20; NEFH; DSP
Function contributes_to receptor binding
Related Protein FGB; FGA
Function structural molecule activity
Related Protein SPRR2D; SYNM; KRT40; CLDN15LB; LAMA2; CLDN11A; IVL; KRT1-C5; ANK1; CDC42SE1

Interacting Protein

FGA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGA here. Most of them are supplied by our site. Hope this information will be useful for your research of FGA.
FGB; FGG; APOA1; KLK6; PASK; F2; MIS12; KRT18; p29991-pro_0000037941; p29991-pro_0000037946; PRRC2A; d-mannose; crlkekhc; IGHG1; IGHA1; ALB

FGA Related Articles

Nimje, SV; Panigrahi, SK; et al. Interfacial failure analysis of functionally graded adhesively bonded double supported tee joint of laminated FRP composite plates. INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES 58:70-79(2015).
Jobse, A; Pieters, M; et al. The contribution of genetic and environmental factors to changes in total and gamma ' fibrinogen over 5 years. THROMBOSIS RESEARCH 135:703-709(2015).