fgb
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  • Official Full Name
  • fibrinogen beta chain
  • Background
  • The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency.
  • Synonyms
  • FGB; fibrinogen beta chain; fibrinogen, B beta polypeptide; MGC104327; MGC120405
Cat.#:FGB-4088HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FGB Protein, GST-tagged
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Cat.#:FGB-74HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGB, His-tagged
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Cat.#:Fgb-5819MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Fgb protein, His-tagged
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Cat.#:FGB-2321RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FGB Protein
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Cat.#:Fgb-5820RTag:His/S
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Fgb protein, His & S-tagged
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Cat.#:FGB-4008CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FGB
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Cat.#:FGB-12042ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FGB
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Cat.#:FGB-5818CTag:His/S
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle FGB protein, His & S-tagged
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Cat.#:FGB-6HTag:N/A
Source (Host):Species:Human
Product nameNative Human Fibrinogen, FITC Labeled
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Cat.#:Fgb -68RTag:N/A
Source (Host):Species:Rat
Product nameNative Rat Fibrinogen
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Cat.#:Fgb-64RTag:N/A
Source (Host):Species:Rat
Product nameNative Rat Fibrinogen, FITC Labeled
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Cat.#:FGB-35DTag:N/A
Source (Host):Species:Dog
Product nameNative Canine Fibrinogen
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Cat.#:FGB-43DTag:N/A
Source (Host):Species:Dog
Product nameNative Canine Fibrinogen, FITC Labeled
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Cat.#:FGB-31BTag:N/A
Source (Host):Species:Bovine
Product nameNative Bovine Fibrinogen
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Cat.#:FGB-40BTag:N/A
Source (Host):Species:Bovine
Product nameNative Bovin Fibrinogen, FITC Labeled
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Cat.#:FGB-56RTag:N/A
Source (Host):Species:Rabbit
Product nameNative Rabbit Fibrinogen, FITC Labeled
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Cat.#:FGB-59RTag:N/A
Source (Host):Species:Rabbit
Product nameNative Rabbit Fibrinogen
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Cat.#:FGB-46PTag:N/A
Source (Host):Species:Pig
Product nameNative Porcine Fibrinogen, FITC Labeled
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Cat.#:FGB-6255HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human FGB 293 Cell Lysate
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Cat.#:FGB-13HTag:
Source (Host):Species:Human
Product nameHuman Fibrinogen Reference Standard
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Cat.#:FGB-37MTag:N/A
Source (Host):Species:Mouse
Product nameMouse Fibrinogen Reference Standard
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Cat.#:FGB-79RTag:N/A
Source (Host):Species:Rat
Product nameRat Fibrinogen Reference Standard
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Cat.#:FGB-19DTag:N/A
Source (Host):Species:Dog
Product nameDog Fibrinogen Reference Standard
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Cat.#:FGB-60PTag:N/A
Source (Host):Species:Pig
Product namePig Fibrinogen Reference Standard
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Involved Pathway

FGB involved in several pathways and played different roles in them. We selected most pathways FGB participated on our site, such as Complement and coagulation cascades, Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Complement and coagulation cascades
SERPING1; CFH; F11; C8B; PLAU; C4BP; SERPINA1A; CFD; C4A; CR1
Platelet activation
P2RX1; MYLK3; PIK3R5; RAP1B; MYLK; P2RY12; PPP1CC; PRKG2; PRKACG; TLN1

Protein Function

FGB has several biochemical functions, for example, contributes_to cell adhesion molecule binding, chaperone binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGB itself. We selected most functions FGB had, and list some proteins which have the same functions with FGB. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to cell adhesion molecule binding
Related Protein FGB; FGA
Function chaperone binding
Related Protein CXorf41; DNAJA2; HYOU1; TIMM44; AHSA2; BAG2; CP; ATP1A1; DNAJA3B; DNAJA2L
Function protein binding
Related Protein NR5A1; PIN1; CCL18; DPP3; FBXL14; TACR2; MRC2; RUNX3; SNX1; CHDH
Function protein binding, bridging
Related Protein TJP2; CUX1; VPS18; MMS19; TRIM17; FKBP4; NCK1; WWC1; COL1A2; RAD50
Function contributes_to receptor binding
Related Protein FGB; FGA
Function structural molecule activity
Related Protein IVL; CLDN6; PGM5; COPE; KRT26; EVPL; SPRR2E; SPRR2H; PLP1; KRT33B

Interacting Protein

FGB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGB here. Most of them are supplied by our site. Hope this information will be useful for your research of FGB.
FGA; p27958-pro_0000037566; KLK6; MIS12; GAMMAHV.ORF10; TK1; ANXA7; p29991-pro_0000037940; p29991-pro_0000308465; CDKN1A; CSNK2B; BKLF1; AIMP2; GRB7; SMN1; PIK3R3

FGB Related Articles

Linden, M; Segersten, U; et al. Tumour expression of bladder cancer-associated urinary proteins. BJU INTERNATIONAL 112:407-415(2013).
Luyckx, VA; Cairo, LV; et al. Oncostatin M pathway plays a major role in the renal acute phase response. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 296:F875-F883(2009).