Fgf15
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Official Full Name
fibroblast growth factor 15
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Overview
Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB. -
Synonyms
FGF19;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- His
- His (Fc)
- Avi
- His|SUMO
- Myc
- DDK
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Mouse | Fgf15-499M | Recombinant Mouse Fgf15, His-tagged | E.coli | His | ||
Mouse | FGF15-5843M | Recombinant Mouse FGF15 Protein | Mammalian Cell | His | ||
Mouse | Fgf15-1213M | Recombinant Mouse Fgf15 Protein, His-SUMO-tagged | E.coli | His/SUMO | ||
Mouse | Fgf15-2996M | Recombinant Mouse Fgf15 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK | ||
Mouse | FGF15-3230M | Recombinant Mouse FGF15 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | Fgf15-01M | Recombinant Mouse Fgf15 Protein, His-tagged | E.coli | His | 26-218 | |
Mouse | FGF15-3230M-B | Recombinant Mouse FGF15 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | FGF15-30R | Recombinant Rat FGF15 protein, His-tagged | E.coli | His | Gly25~Lys218 |
- Involved Pathway
- Protein Function
- Interacting Protein
- Fgf15 Related Research Area
- Fgf15 Related Signal Pathway
Fgf15 involved in several pathways and played different roles in them. We selected most pathways Fgf15 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Fgf15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
MAPK signaling pathway | PLA2G4D;MAPKAPK3;MAPKAPK2;MAP3K13;CACNA1C;AKT3A;NLK2;TAB2;RPS6KA6 |
Ras signaling pathway | PAK6;PRKACG;GAB2;GRIN2A;RALBP1;GNGT1;FGF3;RAB5C;GNB4 |
Rap signaling pathway | IGF1;P2RY1;PFN1;RALB;FGF2;FGF17;FGF4;PRKD1;ITGB1 |
PIK-Akt signaling pathway | G6PC3;PHLPP1;TLR4;RHEB;Ifna11;BCL2L1;FGF14;ITGA4;SOS1 |
Regulation of actin cytoskeleton | FGF1A;RAC1;PIKFYVE;MYLPF;FGF4;PIK3CD;PFN3;PPP1CAA;HRASB |
Pathways in cancer | PTGS2;PLD1;FASLG;MSH3;FGF6;GNGT1;FH1;CCNA1;CBLB |
Melanoma | BRAF;FGF3;IGF1R;FGF10;BAD;PIK3R2;PDGFRB;MAP2K2;FGF18 |
Fgf15 has several biochemical functions, for example, fibroblast growth factor receptor binding, growth factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Fgf15 itself. We selected most functions Fgf15 had, and list some proteins which have the same functions with Fgf15. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
fibroblast growth factor receptor binding | FRS3;FGF20B;FGF20;KLB;FGF1;FGF16;FGF5;FGF10A;FGF18A |
growth factor activity | CSF2;GDNF;TGFA;GDF10B;IL11;FGF11;MSTNA;OSM;EREG |
protein binding | NLRP1;TMEM123;MUSK;ERP44;E2F2;MIER1;HSPA4L;PTK2;TRIM22 |
receptor binding | ANG;PVRL3;P2RX4;GIPC1;PVRL2L;PAOX;LRP6;FGF11A;EPB49 |
Fgf15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Fgf15 here. Most of them are supplied by our site. Hope this information will be useful for your research of Fgf15.
- Q&As
- Reviews
Q&As (5)
Ask a questionFGF15 contributes to energy homeostasis by affecting nutrient absorption and metabolism in the small intestine and liver.
Yes, there are clinical trials investigating the use of FGF15 analogs or modulators for the treatment of metabolic disorders, including obesity and diabetes.
FGF15 plays a role in glucose and lipid metabolism by influencing the expression of genes involved in these processes in the liver.
FGF15 is a key player in the gut-liver axis, influencing communication between the gut and the liver. Understanding this axis is crucial for developing targeted therapies for liver and metabolic diseases.
The potential side effects and risks of FGF15-based therapies are still under investigation in clinical trials, and the safety profile is not fully established.
Customer Reviews (3)
Write a reviewWith its remarkable quality, reliability, and the manufacturer's excellent technical support, I am confident that it will be an invaluable asset in driving my scientific inquiries forward and facilitating groundbreaking discoveries in my field.
This variety allows me to select the most appropriate option based on the specific requirements of my research.
The manufacturer's commitment to quality control and rigorous testing guarantees the reliability and reproducibility of the FGF15 protein, which is essential for obtaining accurate and consistent results.
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