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FKTN

Official Full Name

fukutin
Overview

The protein encoded by this gene is a putative transmembrane protein that is localized to the cis-Golgi compartment, where it may be involved in the glycosylation of alpha-dystroglycan in skeletal muscle. The encoded protein is thought to be a glycosyltransferase and could play a role in brain development. Defects in this gene are a cause of Fukuyama-type congenital muscular dystrophy (FCMD), Walker-Warburg syndrome (WWS), limb-girdle muscular dystrophy type 2M (LGMD2M), and dilated cardiomyopathy type 1X (CMD1X). Alternatively spliced transcript variants have been found for this gene.
Synonyms

FKTN; fukutin; FCMD, Fukuyama type congenital muscular dystrophy (fukutin); LGMD2M; CMD1X; FCMD; FKTN_HUMAN; Fukuyama type congenital muscular dystrophy protein; Fukuyama-type congenital muscular dystrophy protein; MDDGA4; MDDGB4; MDDGC4; MGC126857; MGC134944; MGC134945; MGC138243; OTTHUMP00000021841;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Cynomolgus monkey
Homo sapiens (Human)
Human
Mouse
Zebrafish

Source

E.coli
E.coli expression system
HEK293
HEK293T
In vitro E. coli expression system
Mammalian Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	FKTN-12921H	Recombinant Human FKTN, His-tagged	E.coli	His	35-461a.a.	$319 / 25ug
Human	FKTN-4016H	Recombinant Human FKTN Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	FKTN-6198HCL	Recombinant Human FKTN 293 Cell Lysate	HEK293	N/A		Inquiry
Human	FKTN-948H	Recombinant Human FKTN Full Length Transmembrane protein, His-tagged	In vitro E. coli expression system	His	1-461aa	Inquiry
Human	FKTN-962H	Recombinant Human FKTN Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Mouse	Fktn-3034M	Recombinant Mouse Fktn Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	Fktn-4255M	Recombinant Mouse Fktn protein, His&Myc-tagged	E.coli	His&Myc	29-461aa	Inquiry
Cynomolgus monkey	FKTN-1335C	Recombinant Cynomolgus monkey FKTN protein, His&Myc-tagged	E.coli	His&Myc	29-461aa	Inquiry
Homo sapiens (Human)	RFL18545HF	Recombinant Full Length Human Fukutin(Fktn) Protein, His-Tagged	E.coli expression system	His	Full Length (1-461aa)	Inquiry
Zebrafish	FKTN-3822Z	Recombinant Zebrafish FKTN	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
FKTN Related Articles

FKTN involved in several pathways and played different roles in them. We selected most pathways FKTN participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FKTN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

FKTN has several biochemical functions, for example, transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FKTN itself. We selected most functions FKTN had, and list some proteins which have the same functions with FKTN. You can find most of the proteins on our site.

Function	Related Protein
transferase activity	PIP5K1BA;TRMT12;GM7168;PKZ;UGT5A4;ELOVL1A;PRDM12;OASL1;FTSJD2

FKTN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FKTN here. Most of them are supplied by our site. Hope this information will be useful for your research of FKTN.

Humphrey, EL; Lacey, E; et al. A new monoclonal antibody DAG-6F4 against human alpha-dystroglycan reveals reduced core protein in some, but not all, dystroglycanopathy patients. NEUROMUSCULAR DISORDERS 25:32-42(2015).

Fortunato, MJ; Ball, CE; et al. Development of Rabbit Monoclonal Antibodies for Detection of Alpha-Dystroglycan in Normal and Dystrophic Tissue. PLOS ONE 9:-(2014).