fmnl3
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  • Official Full Name
  • formin-like 3
  • Background
  • The protein encoded by this gene contains a formin homology 2 domain and has high sequence identity to the mouse Wbp3 protein. Two alternative transcripts encoding different isoforms have been described.
  • Synonyms
  • FMNL3; formin-like 3; formin-like protein 3; DKFZp762B245; MGC45819; WBP3; WW domain binding protein 3; WW domain-binding protein 3; formin homology 2 domain-containing protein 3; FHOD3; WBP-3; FLJ45265
Cat.#:FMNL3-2435HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human FMNL3 Protein, MYC/DDK-tagged
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Cat.#:FMNL3-4391HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FMNL3 Protein, GST-tagged
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Cat.#:FMNL3-5936MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FMNL3 Protein
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Cat.#:FMNL3-659HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human FMNL3 cell lysate
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Involved Pathway

FMNL3 involved in several pathways and played different roles in them. We selected most pathways FMNL3 participated on our site, such as Downregulation of ERBB2:ERBB3 signaling, Endocytosis, ErbB2/ErbB3 signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with FMNL3 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Downregulation of ERBB2:ERBB3 signaling
FMNL3; RNF41; NRG2A
Endocytosis
LDLR; GRK1; FOLR1; EPN3; HSPA6; RHOAA; ARPC2; ARPC5L; IGF1RB; VPS26BL
ErbB2/ErbB3 signaling events
DOCK7; RNF41; CHRNA1; CHRNE; FMNL3
Internalization of ErbB1
FMNL3; SPRY2; RNF103-CHMP3; ZFYVE28; STAMBP
Regulation of FZD by ubiquitination
RSPO4; RNF43; LGR5; ZNRF3; LGR4; LGR6; RSPO2; RSPO3; RSPO1; FMNL3
Signal Transduction
RGS14; RARG; OR2AP1; IRBP; STARD13; ARHGAP40; ALDH8A1; ARHGAP19; QRFP; PRICKLE1
Signaling by ERBB2
FMNL3; CUL5A
Signaling by Wnt
TNKS; C; RSPO3; SRY; SOX7; PYGO2; WLS; KREMEN2; CSNK1G2; DACT1

Protein Function

FMNL3 has several biochemical functions, for example, SH3 domain binding, cysteine-type endopeptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FMNL3 itself. We selected most functions FMNL3 had, and list some proteins which have the same functions with FMNL3. You can find most of the proteins on our site.
Function
Related Protein
Function SH3 domain binding
Related Protein MICAL1; GRIK5; SHANK1; CABYR; FMN1; SHANK2; LYN; PTPN12; UVRAG; FMNL3
Function cysteine-type endopeptidase activity
Related Protein CASP8L1; CASP2; CASP9; CTSL1B; USP24; USP18; CTSW; CTSL1; USP2; USP45
Function protein binding
Related Protein PARP2; HER5; TBX22; TNFRSF13B; EPS15; HSD17B14; VPS37A; WRAP53; CRB1; HIST1H2BB
Function ubiquitin-specific protease activity
Related Protein USP43A; USP8; USP7; OTUD7A; OTUB1; DUB1; OTUD5A; USP51; USP20; UCHL3

Interacting Protein

FMNL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FMNL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FMNL3.
Dlg4; PRPF40A

FMNL3 Related Articles

Gauvin, TJ; Young, LE; et al. The formin FMNL3 assembles plasma membrane protrusions that participate in cell-cell adhesion. MOLECULAR BIOLOGY OF THE CELL 26:467-477(2015).
Wakayama, Y; Fukuhara, S; et al. Cdc42 Mediates Bmp-Induced Sprouting Angiogenesis through Fmnl3-Driven Assembly of Endothelial Filopodia in Zebrafish. DEVELOPMENTAL CELL 32:109-122(2015).