fmnl3
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  • Official Full Name
  • formin-like 3
  • Background
  • The protein encoded by this gene contains a formin homology 2 domain and has high sequence identity to the mouse Wbp3 protein. Two alternative transcripts encoding different isoforms have been described.
  • Synonyms
  • FMNL3; formin-like 3; formin-like protein 3; DKFZp762B245; MGC45819; WBP3; WW domain binding protein 3; WW domain-binding protein 3; formin homology 2 domain-containing protein 3; FHOD3; WBP-3; FLJ45265
Cat.#:FMNL3-2435HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human FMNL3 Protein, MYC/DDK-tagged
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Cat.#:FMNL3-4391HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FMNL3 Protein, GST-tagged
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Cat.#:FMNL3-5936MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FMNL3 Protein
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Cat.#:FMNL3-659HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human FMNL3 cell lysate
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Involved Pathway

FMNL3 involved in several pathways and played different roles in them. We selected most pathways FMNL3 participated on our site, such as Downregulation of ERBB2:ERBB3 signaling, Endocytosis, ErbB2/ErbB3 signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with FMNL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Downregulation of ERBB2:ERBB3 signaling
RNF41; FMNL3; NRG2A
Endocytosis
CYTH4; LDLRAP1B; ARF1L; TGFBR2; RAB11FIP4B; DNM3; GRK1A; FMNL3; RAB11FIP1; WASL
ErbB2/ErbB3 signaling events
FMNL3; RNF41; CHRNE; CHRNA1; DOCK7
Internalization of ErbB1
ZFYVE28; SPRY2; FMNL3; STAMBP; RNF103-CHMP3
Regulation of FZD by ubiquitination
LGR5; LGR6; RSPO2; LGR4; RSPO3; RNF43; RSPO4; ZNRF3; RSPO1; FMNL3
Signal Transduction
TLE3B; APOA4B.1; DLK1; SOX4A; LPAR2B; GPR18; ZFPM2B; ACKR4; PYY; CCRL2
Signaling by ERBB2
CUL5A; FMNL3
Signaling by Wnt
RSPO3; KREMEN1; ZNRF3; SOX9A; SOX9B; KREMEN2; WNT8-2; SOX6; TMED5; BCL9L

Protein Function

FMNL3 has several biochemical functions, for example, SH3 domain binding, cysteine-type endopeptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FMNL3 itself. We selected most functions FMNL3 had, and list some proteins which have the same functions with FMNL3. You can find most of the proteins on our site.
Function
Related Protein
Function SH3 domain binding
Related Protein ADAM12; DOCK4; ARHGAP1; FMNL3; SOS1; CBLC; INPPL1B; SKAP1; KHDRBS1; BCAR1
Function cysteine-type endopeptidase activity
Related Protein USP20; USP24; CTSH; USP5; USP13; USP9X; CTSL1; ATG4B; USP16; CASPA
Function protein binding
Related Protein UFL1; ZNF238; ABCB9; EIF4G2; PDLIM7; DNER; FEM1B; CDKN2D; CAV3; DZIP1L
Function ubiquitin-specific protease activity
Related Protein USP13; USP43A; UCHL3; USP10; IWS1; OTUD6A; USP12A; USP47; USP48; USP33

Interacting Protein

FMNL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FMNL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FMNL3.
Dlg4; PRPF40A

FMNL3 Related Articles

Gauvin, TJ; Young, LE; et al. The formin FMNL3 assembles plasma membrane protrusions that participate in cell-cell adhesion. MOLECULAR BIOLOGY OF THE CELL 26:467-477(2015).
Wakayama, Y; Fukuhara, S; et al. Cdc42 Mediates Bmp-Induced Sprouting Angiogenesis through Fmnl3-Driven Assembly of Endothelial Filopodia in Zebrafish. DEVELOPMENTAL CELL 32:109-122(2015).