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FMNL3

  • Official Full Name

    formin-like 3

  • Overview

    The protein encoded by this gene contains a formin homology 2 domain and has high sequence identity to the mouse Wbp3 protein. Two alternative transcripts encoding different isoforms have been described.
  • Synonyms

    FMNL3; formin-like 3; formin-like protein 3; DKFZp762B245; MGC45819; WBP3; WW domain binding protein 3; WW domain-binding protein 3; formin homology 2 domain-containing protein 3; FHOD3; WBP-3; FLJ45265;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FMNL3-659HCL Recombinant Human FMNL3 cell lysate N/A
Human FMNL3-4986HF Recombinant Full Length Human FMNL3 Protein, GST-tagged In Vitro Cell Free System GST 347 amino acids
Human FMNL3-2435H Recombinant Human FMNL3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human FMNL3-4391H Recombinant Human FMNL3 Protein, GST-tagged Wheat Germ GST
Mouse FMNL3-5936M Recombinant Mouse FMNL3 Protein Mammalian Cell His
Mouse FMNL3-3288M-B Recombinant Mouse FMNL3 Protein Pre-coupled Magnetic Beads HEK293
Mouse FMNL3-3288M Recombinant Mouse FMNL3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Fmnl3-3052M Recombinant Mouse Fmnl3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FMNL3 Related Articles

FMNL3 involved in several pathways and played different roles in them. We selected most pathways FMNL3 participated on our site, such as Downregulation of ERBB2:ERBB3 signaling, Endocytosis, ErbB2/ErbB3 signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with FMNL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Downregulation of ERBB2:ERBB3 signalingNRG2A;FMNL3;RNF41
EndocytosisRET;ZFYVE9;IST1;IGF1RA;ZFYVE27;GRK7;CYTH1A;ERBB4A;WASLB
ErbB2/ErbB3 signaling eventsCHRNE;DOCK7;RNF41;CHRNA1;FMNL3
Internalization of ErbB1ZFYVE28;SPRY2;FMNL3;RNF103-CHMP3;STAMBP
Regulation of FZD by ubiquitinationFMNL3;RNF43;RSPO2;LGR6;LGR5;RSPO4;LGR4;RSPO1;ZNRF3
Signal TransductionFSTL1A;GDI2;METAP2;OTUD7B;CSNK1G2;GPR18;HCRT;CRABP1B;DLC1
Signaling by ERBB2FMNL3;CUL5A
Signaling by WntPRICKLE1;TNKS;SRY;RNF146;LGR6;WLS;WNT8-2;USP34;RSPO3

FMNL3 has several biochemical functions, for example, SH3 domain binding, cysteine-type endopeptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FMNL3 itself. We selected most functions FMNL3 had, and list some proteins which have the same functions with FMNL3. You can find most of the proteins on our site.

Function Related Protein
SH3 domain bindingKHDRBS1;MAPK15;ENKUR;DNAJC6;FUT8;ILK;FMNL3;ADAM15;ARHGAP6
cysteine-type endopeptidase activityCTSM;FAM49BA;CASPB;USP17L2;CTSH;PSD;USP20;ESPL1;USP30
protein bindingATP6V1H;NT5C3B;PPAP2B;E2F1;PENK;CDPF1;PCM1;C12orf68;FBL
ubiquitin-specific protease activityUCHL1;USP2;USP51;USP33;OTUB2;USP2A;USP31;STAMBP;UFD1L

FMNL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FMNL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FMNL3.

Dlg4; PRPF40A

Gauvin, TJ; Young, LE; et al. The formin FMNL3 assembles plasma membrane protrusions that participate in cell-cell adhesion. MOLECULAR BIOLOGY OF THE CELL 26:467-477(2015).
Wakayama, Y; Fukuhara, S; et al. Cdc42 Mediates Bmp-Induced Sprouting Angiogenesis through Fmnl3-Driven Assembly of Endothelial Filopodia in Zebrafish. DEVELOPMENTAL CELL 32:109-122(2015).
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