FMR1
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Official Full Name
fragile X mental retardation 1
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Overview
The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5 UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene. [provided by RefSeq, May 2010] -
Synonyms
FMR1; fragile X mental retardation 1; POF; FMRP; POF1; FRAXA; fragile X mental retardation protein 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- FMR1 Related Articles
FMR1 involved in several pathways and played different roles in them. We selected most pathways FMR1 participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with FMR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA transport | EEF1A1L2;NUP107;EIF3HB;EIF4EBP2;NUP62;THOC6;NUP54;EEF1A1A;BAT1 |
FMR1 has several biochemical functions, for example, RNA binding, mRNA binding, microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FMR1 itself. We selected most functions FMR1 had, and list some proteins which have the same functions with FMR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA binding | THOC6;JAKMIP1;EIF4G2B;RCAN3;NOL9;FMR1;RBM39B;NHP2L1B;CPEB1B |
| mRNA binding | PURB;SSB;HNRNPAB;ZFP36L1;RBMX;QK;AGO2;RBFOX2;CLUHA |
| microtubule binding | LRPPRC;MAP6D1;PRC1B;CKAP5;CAMSAP1B;KIF3B;NEFM;SPAG8;SGIP1 |
| poly(A) RNA binding | EIF2AK2;LARP7;Cstb;EEF2;FASN;RPS9;HSPA9;SRSF5;GTPBP1 |
| protein binding | DRAXIN;HMGN2;TRPC7;USP20;CLIP4;KBTBD7;AEBP2;ZFYVE1;NTS |
FMR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FMR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FMR1.
CYFIP2; CYFIP1; ESR2; STAU1; PRKAA1; HABP4; Rcan1; LIMS1; fhaC2; Cyfip1; TBKBP1; 7-methyl-gtp
- Q&As
- Reviews
Q&As (7)
Ask a questionMutations in FMR1 can impact emotional and behavioral regulation, contributing to mood and behavioral disorders.
FMR1 plays a critical role in cognitive development, influencing how the brain processes and stores information.
FMR1 deficiency causes Fragile X syndrome, leading to intellectual disability and developmental delays.
FMR1 is associated with autism spectrum disorders, affecting brain development and social-communication skills.
FMR1 is key in regulating synaptic function and plasticity, essential for learning and memory.
Changes in FMR1 can affect reproductive health, particularly in carriers of Fragile X mutations, impacting fertility and genetic risks.
FMR1 modulates gene expression and protein synthesis in neurons, crucial for normal brain function.
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