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FOLR2

  • Official Full Name

    folate receptor 2 (fetal)

  • Overview

    The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms

    FOLR2; folate receptor 2 (fetal); FBP; FR-P3; FR-BETA; BETA-HFR; FBP/PL-1; folate receptor beta; folate receptor, beta; folate receptor, fetal/placental; placental folate-binding protein; folate-binding protein, fetal/placental;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Human Cell
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FOLR2-28943TH Recombinant Human FOLR2 Wheat Germ N/A 93 amino acids
Human FOLR2-031H Active Recombinant Human FOLR2 protein, His-tagged HEK293 His Thr 17 - His 228
Human FOLR2-2244H Recombinant Human FOLR2, His tagged Human Cell His
Human FOLR2-2541HCL Recombinant Human FOLR2 cell lysate Human Cell N/A
Human FOLR2-4420H Recombinant Human FOLR2 Protein, GST-tagged Wheat Germ GST
Human FOLR2-5036HF Recombinant Full Length Human FOLR2 Protein, GST-tagged In Vitro Cell Free System GST 255 amino acids
Human FOLR2-254H Recombinant Human FOLR2 Protein, His-tagged HEK293 His 255
Human FOLR2-2815H Recombinant Human FOLR2 Protein (19-230 aa), His-tagged Insect Cell His 19-230 aa
Human FOLR2-005H Active Recombinant Human FOLR2 Protein, His-tagged HEK293 His
Human FOLR2-1434H Active Recombinant Human FOLR2 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Thr17-His228
Human FOLR2-2532H Recombinant Human FOLR2 Protein (Thr17-Asn230), N-His tagged E.coli N-His Thr17-Asn230
Mouse FOLR2-5968M Recombinant Mouse FOLR2 Protein Mammalian Cell His
Mouse FOLR2-3308M-B Recombinant Mouse FOLR2 Protein Pre-coupled Magnetic Beads HEK293
Mouse FOLR2-3308M Recombinant Mouse FOLR2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus FOLR2-1435C Active Recombinant Cynomolgus FOLR2 protein, His-tagged HEK293 His Thr34-His245
Rhesus Macaque FOLR2-1737R Recombinant Rhesus monkey FOLR2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque FOLR2-1559R Recombinant Rhesus Macaque FOLR2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque FOLR2-1559R-B Recombinant Rhesus Macaque FOLR2 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein

FOLR2 involved in several pathways and played different roles in them. We selected most pathways FOLR2 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOLR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
EndocytosisMET;IQSEC1;NEDD4;SPG20;RAB7A;SH3GL3A;ARFGEF2;PIP5K1AA;PIP5K1BB

FOLR2 has several biochemical functions, for example, drug binding, folic acid binding, folic acid receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FOLR2 itself. We selected most functions FOLR2 had, and list some proteins which have the same functions with FOLR2. You can find most of the proteins on our site.

Function Related Protein
drug bindingCYP4B1;DRD4;HMGB2;CHRNA2;UGT1A7;CYP2D6;TLR7;CHRM2;P2RX1
folic acid bindingDMGDH;SLC46A1;DHFR;TYMS;FOLR1;SLC19A1;MTHFS;GNMT;FOLR2
folic acid receptor activityDAAM2;FOLR2
folic acid transporter activityDAAM2;SLC19A2;FOLR1;SLC46A1;SLC19A1;FOLR2;SLC25A32
methotrexate bindingFOLR1;DHFR;FOLR2;DAAM2

FOLR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOLR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOLR2.

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