fpgt
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  • Official Full Name
  • fucose-1-phosphate guanylyltransferase
  • Background
  • L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of the functional roles of these macromolecules, such as in cell-cell recognition. The fucosyl donor for these fucosylated oligosaccharides is GDP-beta-L-fucose. There are two alternate pathways for the biosynthesis of GDP-fucose; the major pathway converts GDP-alpha-D-mannose to GDP-beta-L-fucose. The protein encoded by this gene participates in an alternate pathway that is present in certain mammalian tissues, such as liver and kidney, and appears to function as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids. This pathway involves the phosphorylation of L-fucose to form beta-L-fucose-1-phosphate, and then condensation of the beta-L-fucose-1-phosphate with GTP by fucose-1-phosphate guanylyltransferase to form GDP-beta-L-fucose. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream TNNI3 interacting kinase (TNNI3K) gene.
  • Synonyms
  • FPGT; fucose-1-phosphate guanylyltransferase; GFPP; Fucose 1 phosphate guanyltransferase; Fucose 1 phosphate guanylyltransferase; GDP beta L fucose pyrophosphorylase; GDP L fucose diphosphorylase; GDP L fucose pyrophosphorylase; GDP-L-fucose diphosphorylase; GDP-beta-L-fucose pyrophosphorylase; fucose-1-phosphate guanyltransferase
Cat.#:FPGT-4484HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FPGT Protein, GST-tagged
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Cat.#:FPGT-740HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FPGT Protein, His-tagged
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Cat.#:Fpgt-741MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Fpgt Protein, His-tagged
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Cat.#:FPGT-1749RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey FPGT Protein, His-tagged
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Cat.#:FPGT-4501CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FPGT
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Cat.#:FPGT-2894ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FPGT
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Cat.#:FPGT-6139HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human FPGT 293 Cell Lysate
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Involved Pathway

FPGT involved in several pathways and played different roles in them. We selected most pathways FPGT participated on our site, such as Fructose and mannose metabolism, Amino sugar and nucleotide sugar metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with FPGT were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Fructose and mannose metabolism
ALDOAA; FBP2; FBP1B; PFKP; HK1; MPI; PFKFB2; FPGT; PFKL; GMPPA
Amino sugar and nucleotide sugar metabolism
GALK1; AMDHD2; PGM3; CMASA; GNPDA2; GMPPAA; GNPNAT1; GFPT2; UGP2B; HK2
Metabolic pathways
GALNT5; DHRS13L1; ALOX12E; MAT2AB; SCLY; ACSL5; MTHFD2L; CMASA; CHDH; TGDS

Protein Function

FPGT has several biochemical functions, for example, GTP binding, catalytic activity, fucose-1-phosphate guanylyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FPGT itself. We selected most functions FPGT had, and list some proteins which have the same functions with FPGT. You can find most of the proteins on our site.
Function
Related Protein
Function GTP binding
Related Protein ARL4D; TUBA2; TUBA1A; RASD1; RAB2A; ADSSL; SEPT5; GMPPB; RAB31; SRP54B
Function catalytic activity
Related Protein AADAC; SCP2A; ALDOCB; PGAM1A; UQCRC2A; LYZ1; GOT2A; ALDH1L1; ACLYA; AZIN1A
Function fucose-1-phosphate guanylyltransferase activity
Related Protein FPGT

FPGT Related Articles

Bochicchio, MA; Vaira, L; et al. FPGT: An Online System for Customized Fetal and Pediatric Growth Tracking. 2014 IEEE-EMBS INTERNATIONAL CONFERENCE ON BIOMEDICAL AND HEALTH INFORMATICS (BHI) :424-427(2014).
Trifonov, VA; Dementyeva, PV; et al. Transcription of a protein-coding gene on B chromosomes of the Siberian roe deer (Capreolus pygargus). BMC BIOLOGY 11:-(2013).