ftcd
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  • Official Full Name
  • formiminotransferase cyclodeaminase
  • Background
  • The protein encoded by this gene is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Mutations in this gene are associated with glutamate formiminotransferase deficiency. Alternatively spliced transcript variants have been found for this gene.
  • Synonyms
  • FTCD; formiminotransferase cyclodeaminase; formimidoyltransferase-cyclodeaminase; formiminotransferase-cyclodeaminase; formimidoyltransferase cyclodeaminase; LCHC1
Cat.#:FTCD-4530HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FTCD Protein, GST-tagged
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Cat.#:FTCD-13023HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FTCD, His-tagged
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Cat.#:FTCD-37HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FTCD, His-tagged
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Cat.#:FTCD-6068MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FTCD Protein
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Cat.#:FTCD-2401RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FTCD Protein
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Cat.#:FTCD-6465CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FTCD
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Cat.#:FTCD-11303ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FTCD
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Cat.#:FTCD-6129HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human FTCD 293 Cell Lysate
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Involved Pathway

FTCD involved in several pathways and played different roles in them. We selected most pathways FTCD participated on our site, such as Histidine catabolism, Histidine metabolism, Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with FTCD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Histidine catabolism
UROC1; AMDHD1; FTCD
Histidine metabolism
CNDP1; ALDH3A1; HAL; ALDH9A1B; MAOA; ALDH9A1A.1; ABP1; ALDH7A1; ALDH2.2; ALDH2
Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism
DLST; IDO2; FTCD; UROC1; CRYM; AMDHD1; ACMSD; PCBD1; AFMID; SLC25A21
Metabolic pathways
B4GALT6; CELL; GCSH; NDUFB6; AKR1B7; NOS1; POLR2G; ybaS; MVK; ACSS3
Metabolism
ACOT9.2; SULT1C2; DGAT1B; ITPKB; SLC25A32; SACM1L; MTP; GLTPD1; TREH; AGPAT6
Metabolism of amino acids and derivatives
AZIN1; CDO1; DIO2; NQO1; AZIN1B; CKM; CKMT2; LSM1; FTCD; IVD
One Carbon Metabolism
ST20-MTHFS; ALDH1L1; AHCY; MTHFD2; MTFMT; FTCD; MTHFS
One carbon pool by folate
SHMT1; ALDH1L1; SHMT2; MTHFS; ALDH1L2; DHFRL1; MTHFD2L; MTHFD1L; MTHFD1; AMT

Protein Function

FTCD has several biochemical functions, for example, folic acid binding, formimidoyltetrahydrofolate cyclodeaminase activity, formimidoyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FTCD itself. We selected most functions FTCD had, and list some proteins which have the same functions with FTCD. You can find most of the proteins on our site.
Function
Related Protein
Function folic acid binding
Related Protein MTHFS; TYMS; DHFR; FOLR2; FOLR3; SLC46A1; FTCD; SLC19A1; DAAM2; FOLR1
Function formimidoyltetrahydrofolate cyclodeaminase activity
Related Protein FTCD
Function formimidoyltransferase activity
Related Protein FTCD
Function glutamate formimidoyltransferase activity
Related Protein FTCD
Function microtubule binding
Related Protein MAP2; KCNH2A; KIF3CB; JAKMIP2; CETN2; CNN3; APC2; ZFP207; SPAST; DPYSL2
Function protein binding
Related Protein MYOCD; KLK13; CALCOCO1; WNT2; FATE1; ACTN3; HSF2; HYPK; PRDX1; HP

Interacting Protein

FTCD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FTCD here. Most of them are supplied by our site. Hope this information will be useful for your research of FTCD.
CCDC155; MED4

FTCD Related Articles

Lapierre, P; Beland, K; et al. Adoptive transfer of ex vivo expanded regulatory T cells in an autoimmune hepatitis murine model restores peripheral tolerance. HEPATOLOGY 57:217-227(2013).
Hagiwara, H; Tajika, Y; et al. Localization of Golgi 58K protein (formiminotransferase cyclodeaminase) to the centrosome. HISTOCHEMISTRY AND CELL BIOLOGY 126:251-259(2006).