fut6
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  • Official Full Name
  • fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
  • Background
  • The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants encoding the same protein have been found for this gene.
  • Synonyms
  • FUT6; fucosyltransferase 6 (alpha (1,3) fucosyltransferase); alpha-(1,3)-fucosyltransferase; alpha (1; 3) fucosyltransferase; FCT3A; FLJ40754; FT1A; FucT VI; galactoside 3 L fucosyltransferase; Alpha (1,3) fucosyltransferase; EC=2.4.1.65; Fuc TVI; Fucosyltransferase 6; Fucosyltransferase VI; galactoside 3-L-fucosyltransferase; Fuc-TVI; FucT-VI
Cat.#:FUT6-4565HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FUT6 Protein, GST-tagged
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Cat.#:FUT6-13045HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FUT6, GST-tagged
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Cat.#:FUT6-1412HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FUT6 protein, His & T7-tagged
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Cat.#:FUT6-3289PTag:His
Source (Host):Mammalian CellsSpecies:Pan troglodytes (Chimpanzee)
Product nameRecombinant Pan troglodytes (Chimpanzee) FUT6, His-tagged
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Cat.#:FUT6-6113HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human FUT6 293 Cell Lysate
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Involved Pathway

FUT6 involved in several pathways and played different roles in them. We selected most pathways FUT6 participated on our site, such as Glycosphingolipid biosynthesis - lacto and neolacto series, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with FUT6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycosphingolipid biosynthesis - lacto and neolacto series
B3GNT2; GCNT2; B3GNT5; ST3GAL3; FUT7; B3GNT2B; FUT5; B3GNT1; B4GALT1; ABO
Metabolic pathways
SPTLC3; DOLK; HSD17B8; HADHAB; NMRK1; PPOX; GATB; IDI1; ATP6V0A1B; SC4MOL

Protein Function

FUT6 has several biochemical functions, for example, 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity, alpha-(1->3)-fucosyltransferase activity, fucosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FUT6 itself. We selected most functions FUT6 had, and list some proteins which have the same functions with FUT6. You can find most of the proteins on our site.
Function
Related Protein
Function 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity
Related Protein FUT6; FUT3
Function alpha-(1->3)-fucosyltransferase activity
Related Protein 4931440L10Rik; FUT11; FUT10; FUT9; GALNT18A; DPY19L1; DPY19L4; FUT7; GALNTL4; B3GNT8
Function fucosyltransferase activity
Related Protein FUT7; FT2; FUT1; 4931440L10Rik; FUT2; GLT8D1; FUT9B; GALNTL4; FUT3; POC1BL

FUT6 Related Articles

Duell, EJ; Bonet, C; et al. Variation at ABO histo-blood group and FUT loci and diffuse and intestinal gastric cancer risk in a European population. INTERNATIONAL JOURNAL OF CANCER 136:880-893(2015).
Groux-Degroote, S; Wavelet, C; et al. B4GALNT2 gene expression controls the biosynthesis of Sd(a) and sialyl Lewis X antigens in healthy and cancer human gastrointestinal tract. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 53:442-449(2014).