FXN
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Official Full Name
frataxin
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Overview
This nuclear gene encodes a mitochondrial protein which belongs to FRATAXIN family. The protein functions in regulating mitochondrial iron transport and respiration. The expansion of intronic trinucleotide repeat GAA results in Friedreich ataxia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009] -
Synonyms
FXN; frataxin; FA; X25; CyaY; FARR; FRDA; frataxin, mitochondrial; Friedreich ataxia protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cynomolgus monkey
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- Yeast
- GST
- His
- His (Fc)
- Avi
- Myc
- His|T7
- SUMO
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
FXN involved in several pathways and played different roles in them. We selected most pathways FXN participated on our site, such as Porphyrin and chlorophyll metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with FXN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Porphyrin and chlorophyll metabolism | HMOX2A;UGT1A7;UROD;GUSB;HMOX1;UGT1A3;ALAS1;UGT1A6B;ALAS2 |
FXN has several biochemical functions, for example, 2 iron, 2 sulfur cluster binding, ferric iron binding, ferrous iron binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FXN itself. We selected most functions FXN had, and list some proteins which have the same functions with FXN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 2 iron, 2 sulfur cluster binding | AOX3L1;FDX1L;ISCU;NDUFV2;SDHB;AOX1;AIFM4;RFESD;FXN |
| ferric iron binding | MIOX;Trf;FTL;FTHL17;ACP5;TH;FTH1B;FTH1;FXN |
| ferrous iron binding | TF;ALKBH3;NT5E;EGLN2;SNCA;DNAJC24;ACP5;CDO1;SERPINB1A |
| ferroxidase activity | CP;HEPH;FXN;HEPHL1;FTH1;FTMT |
| iron chaperone activity | |
| iron-sulfur cluster binding | AOX3L1;NDUFS1;NUBP1;AOX4;ELP3;ISCUB;RSAD1;RPS3;AIFM4 |
| protein binding | PTPRM;UFL1;RAI2;HRK;EPB41B;OSBPL6;DCAF11;HIST1H2AH;NEU2 |
FXN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FXN here. Most of them are supplied by our site. Hope this information will be useful for your research of FXN.
PASK; SDHB; SDHA; ACTN1; PICK1
- Q&As
- Reviews
Q&As (5)
Ask a questionFXN interacts with iron regulatory proteins, influencing cellular iron homeostasis by modulating the expression of genes involved in iron metabolism.
FXN deficiency increases cellular sensitivity to oxidative stress due to the disruption of iron homeostasis, leading to the accumulation of reactive oxygen species and cellular damage.
FXN assists in the formation of iron-sulfur clusters by providing a scaffold for the assembly of iron and sulfur atoms, promoting the stability and functionality of these clusters.
FXN influences cellular energy metabolism by supporting the function of iron-sulfur cluster-containing enzymes involved in key metabolic pathways, such as the tricarboxylic acid (TCA) cycle.
FXN deficiency results in impaired iron-sulfur cluster assembly, leading to mitochondrial dysfunction, oxidative stress, and ultimately causing Friedreich's ataxia.
Customer Reviews (3)
Write a reviewCustomer service was courteous and efficient, guiding us through the product selection process with expertise.
The consistent quality of this product has made it a staple in our lab, contributing to the success of various research projects.
Delivery was quick and hassle-free, allowing us to proceed with our experiments without any unnecessary delays.
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