fxn
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  • Official Full Name
  • frataxin
  • Background
  • This nuclear gene encodes a mitochondrial protein which belongs to FRATAXIN family. The protein functions in regulating mitochondrial iron transport and respiration. The expansion of intronic trinucleotide repeat GAA results in Friedreich ataxia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]
  • Synonyms
  • FXN; frataxin; FA; X25; CyaY; FARR; FRDA; frataxin, mitochondrial; Friedreich ataxia protein;
Cat.#:FXN-1060MTag:His
Source (Host):E. coliSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus Monkey FXN Protein (81-210 aa), His-tagged
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Cat.#:FXN-1397MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse FXN Protein (78-207 aa), His-tagged
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Cat.#:FXN-4576HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FXN Protein, GST-tagged
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Cat.#:Fxn-1218RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Fxn Protein, His-tagged
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Cat.#:FXN-13051HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FXN, His-tagged
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Cat.#:FXN-1823HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FXN protein, His-tagged
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Cat.#:FXN-19HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FXN protein, His-tagged
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Cat.#:FXN-6100MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FXN Protein
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Cat.#:Fxn-7819MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Fxn protein, His & T7-tagged
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Cat.#:FXN-530CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus FXN Protein, His-tagged
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Cat.#:FXN-1771RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey FXN Protein, His-tagged
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Cat.#:FXN-5339ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FXN
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Cat.#:FXN-6108HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human FXN 293 Cell Lysate
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Involved Pathway

FXN involved in several pathways and played different roles in them. We selected most pathways FXN participated on our site, such as Porphyrin and chlorophyll metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with FXN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Porphyrin and chlorophyll metabolism
FXN; UGT1A7; UGT1A6A; HMOX2; P22; UGT5G1; EARS2; MMAB; UGT1AB; HMOX2A

Protein Function

FXN has several biochemical functions, for example, 2 iron, 2 sulfur cluster binding, ferric iron binding, ferrous iron binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FXN itself. We selected most functions FXN had, and list some proteins which have the same functions with FXN. You can find most of the proteins on our site.
Function
Related Protein
Function 2 iron, 2 sulfur cluster binding
Related Protein AIFM4; GLRX5; ISCU; CIAPIN1; AOX1; CMAH; FDX1L; AOX3L1; ISCUB; RFESD
Function ferric iron binding
Related Protein FTL; FXN; Trf; FTMT; ACP5; TF; FTH1B; FTH1A; FTHL17; MIOX
Function ferrous iron binding
Related Protein SERPINB1A; ALKBH2; TET2; CDO1; ALKBH3; FTO; PLOD1; ISCA2; NT5E; HEPH
Function ferroxidase activity
Related Protein FTMT; FXN; HEPH; HEPHL1; CP; FTH1
Function iron chaperone activity
Related Protein FXN
Function iron-sulfur cluster binding
Related Protein EXO5; CISD3; ABAT; RSAD1; GLRX3; CMAH; NUBP1; RPS3; ELP3; PRIM2
Function protein binding
Related Protein DNPEP; SCHIP1; ANXA2; RNF182; PEA15; IWS1; FBXL3; N4BP2L2; MKNK2; SGTA

Interacting Protein

FXN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FXN here. Most of them are supplied by our site. Hope this information will be useful for your research of FXN.
PASK; SDHB; SDHA; ACTN1; PICK1