Fzd8
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Official Full Name
frizzled family receptor 8
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Overview
This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain;proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled;receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human;cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the;extracellular cysteine-rich domain of a similar mouse protein has been determined. -
Synonyms
FZD8; frizzled family receptor 8; frizzled (Drosophila) homolog 8 , frizzled 8, seven transmembrane spanning receptor , frizzled homolog 8 (Drosophila); frizzled-8; frizzled homolog 8; frizzled 8, seven transmembrane spanning receptor; FZ-8; hFZ8;
- Recombinant Proteins
- Therapeutic Proteins
- Protein Pre-coupled Magnetic Beads
- Gallus gallus (Chicken)
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- Xenopus laevis (African clawed frog)
- CHO
- E.coli expression system
- HEK293
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Fc
- GST
- His
- His (Fc)
- Avi
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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| Human | FZD8-597H | Active Recombinant Human Frizzled Family Receptor 8, Fc-tagged | CHO | Fc |
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| Human | FZD8-596H | Recombinant Human FZD8(Ala28-Pro172) Protein, C-6*His-tagged | HEK293 | His |
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| Human | FZD8-P012H | Recombinant Human FZD8, Fc-tagged therapeutic protein | Fc |
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| Human | FZD8-4600H | Recombinant Human FZD8 Protein, GST-tagged | Wheat Germ | GST |
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| Human | FZD8-946HB | Recombinant Human FZD8 protein, His-Avi-tagged, Biotinylated | HEK293 | His-Avi | Ala28-Pro172 |
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| Mouse | Fzd8-593M | Active Recombinant Mouse Frizzled Homolog 8 (Drosophila), Fc-tagged | Mammalian cells | Fc |
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| Mouse | FZD8-6122M | Recombinant Mouse FZD8 Protein | Mammalian Cell | His |
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| Mouse | Fzd8-55M-B | Recombinant Mouse Fzd8 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | Fzd8-55M | Recombinant Mouse Fzd8 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | FZD8-2432R | Recombinant Rat FZD8 Protein | Mammalian Cell | His |
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| Rat | FZD8-2088R-B | Recombinant Rat FZD8 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | FZD8-2088R | Recombinant Rat FZD8 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Gallus gallus (Chicken) | RFL15847GF | Recombinant Full Length Chicken Frizzled-8(Fzd8) Protein, His-Tagged | E.coli expression system | His | Full Length (1-217) |
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| Homo sapiens (Human) | RFL24588HF | Recombinant Full Length Human Frizzled-8(Fzd8) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (28-694) |
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| Mus musculus (Mouse) | RFL21170MF | Recombinant Full Length Mouse Frizzled-8(Fzd8) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (28-685) |
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| Rattus norvegicus (Rat) | RFL3704RF | Recombinant Full Length Rat Frizzled-8(Fzd8) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (28-684) |
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| Xenopus laevis (African clawed frog) | RFL30853XF | Recombinant Full Length Xenopus Laevis Frizzled-8(Fzd8) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (24-581) |
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- Involved Pathway
- Protein Function
- Interacting Protein
- Fzd8 Related Articles
- Fzd8 Related Signal Pathway
Fzd8 involved in several pathways and played different roles in them. We selected most pathways Fzd8 participated on our site, such as Wnt signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with Fzd8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Wnt signaling pathway | RAC3;FOSL1A;NFATC1;SKP1;FZD9B;FBXW2;APC;WNT10B;CAMK2G1 |
| Hippo signaling pathway | SCRIB;WNT3A;PPP2R1A;WNT5A;TGFBR2;JUB;GLI2;PRKCI;WNT7A |
| Signaling pathways regulating pluripotency of stem cells | NANOG;HRAS;BMI1;INHBA;WNT16;APC;FGFR2;NEUROG1;JARID2 |
| Melanogenesis | ADCY2B;CALM2A;CAMK2B1;MAP2K2B;POMC;CAMK2D1;TYRP1;CREB3L2;CAMK2D2 |
| HTLV-I infection | TGFBR2;Fzd4;HLA-DOA;ANAPC5;PIK3CG;RELB;NFATC2;RANBP1;AKT2 |
| Pathways in cancer | BIRC3;TFG;WNT16;WNT10B;LPAR3;PLD1;RET;DAPK3;PRKACG |
| Proteoglycans in cancer | ANK1;PIK3CG;RPS6KB2;TLR2;AKT2;WNT2;PTPN11;FGFR1;PIK3R1 |
| Basal cell carcinoma | PTCH2;LEF1;SUFU;WNT10B;APC2;WNT4;SMO;DVL2;TCF7 |
Fzd8 has several biochemical functions, for example, G-protein coupled receptor activity, PDZ domain binding, Wnt-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Fzd8 itself. We selected most functions Fzd8 had, and list some proteins which have the same functions with Fzd8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled receptor activity | GPR27;VMN2R26;SMO;CELSR3;TAS2R20;OR2B3;GPR22;GPR68;PTGER4B |
| PDZ domain binding | SLC22A5;LNX2;DLG1;KIDINS220;SLC9A3;CFTR;FZD8;PTENA;PSEN1 |
| Wnt-activated receptor activity | FZD10;FZD9;FZD5;FZD9B;FZD8;FZD8A;FZD3A;FZD7B;FZD3 |
| Wnt-protein binding | WLS;FZD2;PORCN;FZD10;CTHRC1;SFRP1A;ROR1;FZD7;GPR177 |
| protein binding | KIAA1109;PLEKHB2;KLB;CAV2;ZNF256;GGA2;PSMB1;YBX1;MGARP |
| receptor binding | FYNA;PSPN;CD70;IFNL3;FZD8;HAMP;MSN;FGG;PVRL2 |
| ubiquitin protein ligase binding | YWHAE;TRP53;PRKAR2A;GABARAPL2;ERBB2;TNFRSF14;RFFL;CDC34A;ABI2 |
Fzd8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Fzd8 here. Most of them are supplied by our site. Hope this information will be useful for your research of Fzd8.
c1q_mouse_complex; WNT3A; SDCBP; C1qa
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