FASN
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Official Full Name
fatty acid synthase
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Overview
Fatty acid synthase (FAS) is an enzyme that in humans is encoded by the FASN geneFatty acid synthase is a multi-enzyme protein that catalyzes fatty acid synthesis. It is not a single enzyme but a whole enzymatic system composed of two identical 272 kDa multifunctional polypeptides, in which substrates are handed from one functional domain to the next. -
Synonyms
FASN; fatty acid synthase; FAS; SDR27X1; short chain dehydrogenase/reductase family 27X; member 1; short chain dehydrogenase/reductase family 27X, member 1; OA-519; MGC14367; MGC15706;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- His|Myc
- Myc
- DDK
- Myc|DDK
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- FASN Related Articles
- FASN Related Research Area
FASN involved in several pathways and played different roles in them. We selected most pathways FASN participated on our site, such as Fatty acid biosynthesis, Metabolic pathways, Fatty acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with FASN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fatty acid biosynthesis | ACACB;ACSL1;ACSL3A;ACSL3B;ECHDC3;ACAA2;OXSM;OLAH;ACSL5 |
| Metabolic pathways | AKR1C4;PI4KAA;CYP3A41A;ENO3;NDUFS8;HAL;SHMT1;PAFAH1B1A;GALCA |
| Fatty acid metabolism | ACOX3;ACADL;ACSL4;SCD;ELOVL5;CPT1C;HSD17B12B;ACADM;ACSL5 |
| AMPK signaling pathway | PCK1;CCNA2;PPP2R2A;RAB11B;PRKAA1;TSC1;PPP2R5C;PPP2R3A;MTOR |
| Insulin signaling pathway | TRIP10;PPP1R3CB;PRKAG1;PPARGC1A;PIK3CG;PRKAR2B;MKNK2A;MTOR;CALM1 |
FASN has several biochemical functions, for example, 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity, 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity, 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FASN itself. We selected most functions FASN had, and list some proteins which have the same functions with FASN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity | |
| 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity | |
| 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity | |
| 3-oxoacyl-[acyl-carrier-protein] synthase activity | FASN;OXSM |
| NADPH binding | QDPR;GRHPR;CBR4;CRYZ;FASN;MTRR;CBR3;DHFR;HMGCR |
| [acyl-carrier-protein] S-acetyltransferase activity | |
| [acyl-carrier-protein] S-malonyltransferase activity | FASN;MCAT |
| drug binding | PYGL;CHRM2;CNR1;TLR8;DAAM2;GABRA1;P2RX4;CHKA;SETD6 |
| enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity | |
| enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity | |
| fatty acid synthase activity | |
| myristoyl-[acyl-carrier-protein] hydrolase activity | OLAH;FASN |
| oleoyl-[acyl-carrier-protein] hydrolase activity | FASN;OLAH |
| palmitoyl-[acyl-carrier-protein] hydrolase activity | FASN;OLAH |
| poly(A) RNA binding | DCAF13;ZFP207;FASN;SARS2;NOL11;TCP1;HELZ2;NOC3L;TXN |
| protein binding | KCNIP3;CRMP1;NKG7;MUC5B;VEZT;TEKT1;BMP10;PGF;LRPPRC |
| protein homodimerization activity | HPS4;RNF40;TLR13;JUP;PEX7;SERPINF2;TREX2;NTRK2;C9orf142 |
FASN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FASN here. Most of them are supplied by our site. Hope this information will be useful for your research of FASN.
q99ib8-pro_0000045603; ILK; YWHAZ; NFKB2; MAP3K1; Bles03; NDRG1; MAP3K3; IKBKG; p29991-pro_0000308465; AKT1; EWSR1; PRR12; 1-phosphatidyl-1d-myo-inositol 3,4,5-trisphosphate
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, several clinical trials are investigating FASN inhibitors as potential treatments for cancer and metabolic disorders.
FASN has been associated with insulin resistance, and its inhibition is being investigated as a potential avenue for treating insulin resistance and type 2 diabetes.
Combination therapies involving FASN inhibitors and other anticancer drugs are being explored to enhance treatment efficacy and reduce potential resistance.
FASN is involved in the synthesis of fatty acids, and its dysregulation can contribute to excessive fat accumulation, potentially leading to obesity.
Emerging research suggests a potential link between FASN and neurodegenerative diseases, but more studies are needed to fully understand this connection.
Customer Reviews (3)
Write a reviewIts high quality and purity ensure accurate and reliable results.
With the manufacturer's unwavering dedication to delivering quality products and unparalleled technical support, I am confident in their ability to help me overcome any challenges and propel my research forward.
The FASN protein exhibits several valuable attributes that make it an excellent choice for my trials.
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