FGA
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Official Full Name
fibrinogen alpha chain
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Overview
The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus. -
Synonyms
Fibrinogen; FGA; FGA protein; FGB; FGG; Fib2; Fibrinogen A alpha polypeptide; Fibrinogen A alpha polypeptide chain; Fibrinogen alpha chain; Fibrinogen B alpha polypeptide; Fibrinogen beta chain; Fibrinogen G alpha polypeptide; Fibrinogen gamma chain; MGC104327; MGC119422; MGC119423; MGC119425; MGC120405;
- Native Proteins
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bovine
- Cattle
- Chicken
- Dog
- Human
- Mouse
- Rabbit
- Rat
- Zebrafish
- Bovine Plasma
- Dog Plasma
- E.coli
- HEK293
- Human plasma
- Human Plasma
- In Vitro Cell Free System
- Mammalian Cell
- Plasma
- Protein Conjugation
- Rabbit Plasma
- Rat plasma
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|T7
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | FGA-78H | Active Native Human Fibrinogen (Pg & vWF depleted) | Human Plasma | N/A | ||
Human | FGA-79H | Active Native Human Fibrinogen | Human Plasma | N/A | ||
Human | FGA-80H | Active Native Human Fibrinogen (plasminogen depleted) | Human Plasma | N/A | ||
Human | FGA-36H | Recombinant Human FGA protein, His-tagged | E.coli | His | ||
Human | FGA-206H | Recombinant Human FGA | Mammalian Cell | His | ||
Human | FGA-618HCL | Recombinant Human FGA cell lysate | N/A | |||
Human | FGA-5H | Native Human Fibrinogen, FITC Labeled | Human plasma | N/A | ||
Human | FGA-2900H | Recombinant Human FGA protein, His-tagged | E.coli | His | 36-218aa | |
Human | FGA-2429H | Recombinant Human FGA Protein (Ala20-Arg218), N-His tagged | E.coli | N-His | Ala20-Arg218 | |
Human | FGA-4087H | Recombinant Human FGA Protein, GST-tagged | Wheat Germ | GST | ||
Human | FGA-4803HF | Recombinant Full Length Human FGA Protein, GST-tagged | In Vitro Cell Free System | GST | 218 amino acids | |
Human | FGA-2945H | Recombinant Human FGA Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Human | FGA-2945H-B | Recombinant Human FGA Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | Fga-299M | Active Native Mouse Fibrinogen | Plasma | N/A | ||
Mouse | Fga-1545M | Recombinant Mouse Fga protein, His-tagged | E.coli | His | Trp357~Asp556 (Accession # E9PV24) | |
Mouse | FGA-5830M | Recombinant Mouse FGA Protein | Mammalian Cell | His | ||
Mouse | Fga-1546M | Recombinant Mouse Fga protein, His & T7-tagged | E.coli | His/T7 | Gly34~Met255 (Accession # E9PV24) | |
Mouse | FGA-3219M-B | Recombinant Mouse FGA Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | FGA-3219M | Recombinant Mouse FGA Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | Fga-1547R | Recombinant Rat Fga protein, His-tagged | E.coli | His | Glu77~Glu244 (Accession # P06399) | |
Rat | Fga-1548R | Recombinant Rat Fga protein, His-tagged | E.coli | His | Thr554~Glu655 (Accession # P06399) | |
Rat | Fga -67R | Native Rat Fibrinogen | Rat plasma | N/A | ||
Rat | Fga-63R | Native Rat Fibrinogen, FITC Labeled | Rat plasma | N/A | ||
Rat | Fga-2808R | Recombinant Rat Fga Protein, His-tagged, OVA Conjugated | Protein Conjugation | N-His | Ala20-Arg36 | |
Rabbit | FGA-58R | Native Rabbit Fibrinogen | Rabbit Plasma | N/A | ||
Rabbit | FGA-55R | Native Rabbit Fibrinogen, FITC Labeled | Rabbit Plasma | N/A | ||
Dog | FGA-34D | Native Canine Fibrinogen | Dog Plasma | N/A | ||
Dog | FGA-42D | Native Canine Fibrinogen, FITC Labeled | Dog Plasma | N/A | ||
Bovine | FGA-30B | Native Bovine Fibrinogen | Bovine Plasma | N/A | ||
Bovine | FGA-39B | Native Bovin Fibrinogen, FITC Labeled | Bovine Plasma | N/A | ||
Cattle | FGA-1544C | Recombinant Cattle FGA protein, His & T7-tagged | E.coli | His/T7 | Gly39~Pro615 (Accession # P02672) | |
Zebrafish | FGA-7799Z | Recombinant Zebrafish FGA | Mammalian Cell | His | ||
Chicken | FGA-6908C | Recombinant Chicken FGA | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- FGA Related Articles
- FGA Related Research Area
FGA involved in several pathways and played different roles in them. We selected most pathways FGA participated on our site, such as Complement and coagulation cascades, Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Complement and coagulation cascades | C4BPA;SERPINA1A;C1QC;Hc;C7;PLAU;KLKB1;F5;A2M |
Platelet activation | ORAI1;PPP1CC;PIK3CB;COL27A1;FGA;GNAI1;ITGA2B;MYLK3;PLA2G4F |
FGA has several biochemical functions, for example, contributes_to cell adhesion molecule binding, protein binding, protein binding, bridging. Some of the functions are cooperated with other proteins, some of the functions could acted by FGA itself. We selected most functions FGA had, and list some proteins which have the same functions with FGA. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
contributes_to cell adhesion molecule binding | FGB;FGA |
protein binding | NXF1;GMCL1;PTEN;DDA1;E2F2;GRIA2;PPP5C;GMNN;GTF2B |
protein binding, bridging | IVL;RAD50;ADAP2;CNKSR1;GOLGA5;DDX20;CUX1;TRIM5;COL1A2 |
contributes_to receptor binding | FGB;FGA |
structural molecule activity | KRT96;LCE3D;KRT9;FGG;KRTAP3-3;KRT23;KRT24;KRT73;KRT26 |
FGA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGA here. Most of them are supplied by our site. Hope this information will be useful for your research of FGA.
FGB; FGG; APOA1; KLK6; PASK; F2; MIS12; KRT18; p29991-pro_0000037941; p29991-pro_0000037946; PRRC2A; d-mannose; crlkekhc; IGHG1; IGHA1; ALB
- Q&As
- Reviews
Q&As (5)
Ask a questionFGA protein levels can be measured through laboratory tests such as fibrinogen assays and coagulation profiles.
FGA protein testing is used as part of the assessment of liver function, as the liver is responsible for the synthesis of fibrinogen.
Low FGA protein levels may lead to an increased risk of bleeding and impaired clot formation.
Conditions such as liver disease, disseminated intravascular coagulation (DIC), and congenital fibrinogen deficiencies can lead to abnormal FGA protein levels.
Treatment for abnormal FGA protein levels may involve addressing the underlying condition and, in some cases, administering fibrinogen replacement therapy.
Customer Reviews (3)
Write a reviewthe manufacturer understands the importance of customization and can offer tailored solutions to meet specific research needs.
From recombinant protein production to modification or labeling services, the company is committed to assisting researchers in obtaining the FGA protein in the format and specifications required for their particular studies.
the FGA protein's exceptional qualities, combined with the manufacturer's comprehensive technical support, make it an ideal choice for researchers seeking reliable experimental materials and reliable assistance in their scientific endeavors.
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