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Fig4

  • Official Full Name

    FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • C
  • Myc
  • DDK
  • GST
  • His
  • His (Fc)
  • Avi
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FIG4-6218HCL Recombinant Human FIG4 293 Cell Lysate HEK293 N/A
Human FIG4-4169H Recombinant Human FIG4 Protein, GST-tagged Wheat Germ GST
Human FIG4-3324H Recombinant Human FIG4 protein, His-tagged E.coli His 654-792 aa
Human FIG4-02HFL Recombinant Full Length Human FIG4 Protein, C-Myc/DDK-tagged HEK293T C-Myc/DDK
Human FIG4-5104HF Recombinant Full Length Human FIG4 Protein, GST-tagged In Vitro Cell Free System GST 907 amino acids
Human FIG4-3828H Recombinant Human FIG4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse FIG4-5886M Recombinant Mouse FIG4 Protein Mammalian Cell His
Mouse FIG4-3258M Recombinant Mouse FIG4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Fig4-226M Recombinant Mouse Fig4 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse FIG4-3258M-B Recombinant Mouse FIG4 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque FIG4-1712R Recombinant Rhesus monkey FIG4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque FIG4-1534R Recombinant Rhesus Macaque FIG4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque FIG4-1534R-B Recombinant Rhesus Macaque FIG4 Protein Pre-coupled Magnetic Beads HEK293
Chicken FIG4-3819C Recombinant Chicken FIG4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Fig4 Related Articles

Fig4 involved in several pathways and played different roles in them. We selected most pathways Fig4 participated on our site, such as 3-phosphoinositide biosynthesis, Metabolism, Metabolism of lipids and lipoproteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with Fig4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
3-phosphoinositide biosynthesisFIG4;CDIPT;PIP5KL1;PIK3R6
MetabolismNDUFA11;SREBF2;CYP2A7;LBR;ELOVL1A;SCO1;NDUFAF6;SLC25A21;FAAH2
Metabolism of lipids and lipoproteinsPTGR1;PPM1LA;ACER1;ARSF;CPTP;NFYBA;SPTLC1;PLIN2;COQ6
PI MetabolismSACM1L;TPTE;FIG4;SACM1LB;SACM1LA;PITPNB;ARF3
Phospholipid metabolismCEPT1;ABHD4;CHKA;PHOSPHO1;SACM1LA;CPNE1;PTPMT1;TPTE;CEPT1A
Synthesis of PIPs at the Golgi membraneFIG4;TPTE;SACM1LB;ARF3;SACM1L;SACM1LA
Synthesis of PIPs at the early endosome membrane
Synthesis of PIPs at the late endosome membrane

Fig4 has several biochemical functions, for example, phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity, phosphatidylinositol-3-phosphatase activity, phosphatidylinositol-4-phosphate phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Fig4 itself. We selected most functions Fig4 had, and list some proteins which have the same functions with Fig4. You can find most of the proteins on our site.

Function Related Protein
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activityNT5DC3;PXYLP1;SACM1LA;PTPRQ;CTDSPL2B;PIKFYVE;FIG4;TENC1;CTDSPL2A
phosphatidylinositol-3-phosphatase activityMTMR1;MTMR1A;MTMR2;FIG4;MTMR8;MTMR3;SACM1L;MTMR1B;MTM1
phosphatidylinositol-4-phosphate phosphatase activitySACM1LB;SGPP2;NT5DC3;CTDSPL2B;SACM1L;SACM1LA;PTPRQ;TENC1;PXYLP1
protein bindingPCP4;ZC3H10;TAF1D;SSRP1;TBC1D9B;SAP30L;NUDT10;CIC;RTN3

Fig4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Fig4 here. Most of them are supplied by our site. Hope this information will be useful for your research of Fig4.

VAC14; pi3p; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate

Vaccari, I; Carbone, A; et al. Loss of Fig4 in both Schwann cells and motor neurons contributes to CMT4J neuropathy. HUMAN MOLECULAR GENETICS 24:383-396(2015).
Liu, ZJ; Li, HF; et al. Identify mutation in amyotrophic lateral sclerosis cases using HaloPlex target enrichment system. NEUROBIOLOGY OF AGING 35:-(2014).
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