Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

FIGF

  • Official Full Name

    C-fos induced growth factor (vascular endothelial growth factor D)

  • Overview

    VEGF-D is a growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. VEGF-D may function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. The protein binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. VEGF-D is a homodimer; it is also non-covalent and antiparallel. VEGF-D is highly expressed in lung, heart, small intestine and fetal lung, and at lower levels in skeletal muscle, colon, and pancreas. VEGF-D undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3 and VEGFR-2. It first forms an antiparallel homodimer linked by disulfide bonds before secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.
  • Synonyms

    VEGF-D; VEGFD; vascular endothelial growth factor D;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • Human
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Rabbit
  • Sf21 Insect Cell
  • Wheat Germ
  • GST
  • hFc
  • His
  • His (Fc)
  • Avi
  • Met|His
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FIGF-976H Active Recombinant Human FIGF Protein, Met & His-tagged Sf21 Insect Cell Met/His Phe93-Ser201
Human FIGF-625H Recombinant Human C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D) Human N/A
Human FIGF-229H Recombinant Human FIGF, His-tagged E.coli His
Human FIGF-167H Active Recombinant Human FIGF E.coli N/A
Human FIGF-212H Recombinant Human FIGF, His tagged Human Cell His
Human FIGF-2767HCL Recombinant Human FIGF cell lysate Human Cell N/A
Human CAB11546RH Rabbit Anti-Human VEGF-D Monoclonal Antibody Rabbit N/A
Human FIGF-301286H Recombinant Human FIGF protein, GST-tagged E.coli GST Ala90-Thr182
Human FIGF-4170H Recombinant Human FIGF Protein, GST-tagged Wheat Germ GST
Human FIGF-5105HF Recombinant Full Length Human FIGF Protein, GST-tagged In Vitro Cell Free System GST 354 amino acids
Mouse Figf-8669M Recombinant Mouse Figf, His tagged Human Cell His
Mouse Figf-358M Recombinant Mouse C-Fos Induced Growth Factor Sf21 Insect Cell N/A
Mouse Figf-870M Active Recombinant Mouse Figf protein, hFc-tagged HEK293 hFc Phe98-Ser206
Mouse FIGF-1312MCL Recombinant Mouse FIGF cell lysate Human Cell N/A
Rat Figf-8715R Active Recombinant Rat Figf protein, hFc-tagged HEK293 hFc Phe94-Arg210
Rat FIGF-2349R Recombinant Rat FIGF Protein Mammalian Cell His
Rat FIGF-1265RCL Recombinant Rat FIGF cell lysate Human Cell N/A
Rat FIGF-2005R Recombinant Rat FIGF Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat FIGF-2005R-B Recombinant Rat FIGF Protein Pre-coupled Magnetic Beads HEK293
Zebrafish FIGF-3727Z Recombinant Zebrafish FIGF Mammalian Cell His
Chicken FIGF-6137C Recombinant Chicken FIGF Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

FIGF involved in several pathways and played different roles in them. We selected most pathways FIGF participated on our site, such as Ras signaling pathway, Rap signaling pathway, Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with FIGF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ras signaling pathwayAKT2;FGF3;ETS1;PIK3CB;FGF19;NGFR;PLA1A;PAK3;KSR1
Rap signaling pathwayGRIN1;VEGFB;PIK3CG;MLLT4;PIK3R2;ITGB1;ANGPT2;PDGFB;RASGRP3
Cytokine-cytokine receptor interactionTP-1;Ccl21c;TGFBR1;TNFRSF1A;TNFB;TNF;CRLF2;BMPR2;TNFSF4
PIK-Akt signaling pathwayGNB3;PPP2R5B;GNGT2;IFNA14;LPAR6;IL4R;IFNA12;GSK3B;GNG12
Focal adhesionVTNB;ACTN3A;GSK3B;MET;PRKCBA;ITGB3;FLT1;LAMC3;ACTB1
Pathways in cancerHDAC2;WNT7A;MAX;LPAR5;GNG8;GLI1;EGLN3;WNT6;LPAR4

FIGF has several biochemical functions, for example, chemoattractant activity, growth factor activity, platelet-derived growth factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FIGF itself. We selected most functions FIGF had, and list some proteins which have the same functions with FIGF. You can find most of the proteins on our site.

Function Related Protein
chemoattractant activityFIGF;CCL3;LGALS3;CXCL12B;PDGFB;CXCL12;CXCL12A;VHL;NTF3
growth factor activityIL34;VEGFA;GH1;GDF6B;BMP2;FGF12B;FGF20A;GMFG;IGF2B
platelet-derived growth factor receptor bindingPDGFA;Pdgfa&Pdgfb;PDGFD;PTPRJ;PDGFC;PDGFRA;TYMP;PDGFB;FIGF
protein homodimerization activityCPNE1;KCNN2;CD226;IRAK2;HELT;GYS2;SRGAP2A;MLL1;KIF20B
vascular endothelial growth factor receptor 3 bindingFIGF;VEGFC;VHL
vascular endothelial growth factor receptor bindingFIGF;VEGFA;CD2AP

FIGF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FIGF here. Most of them are supplied by our site. Hope this information will be useful for your research of FIGF.

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