FN1
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Official Full Name
fibronectin 1
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Overview
Fibronectin (FN) is a major component of the extracellular matrix and blood plasma, and is a specific ligand for several integrin adhesion receptors. Fibronectin plays an important role not only in cell adhesion and wound healing but also in embryogenesis and hematopoiesis. Fibronectin is over-expressed in cardiovascular disease states such as atherosclerosis and myocardial infarction. Reduced levels of Fibronectin have been reported in patients with Disseminated Intravascular Coagulation (DIC) and low concentrations appear to correlate with a poor prognosis. -
Synonyms
Fn1; fibronectin 1; fn-1; FIBNEC; fibronectin; FN;
- Recombinant Proteins
- GMP Proteins
- Cell & Tissue Lysates
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Bovine
- Chicken
- Human
- Mouse
- Pig
- Rat
- Bovine Plasma
- CHO-K1
- E.coli
- HEK293
- HEK293F
- Human blood/plasma
- Human Cell
- Human Foreskin Fibroblasts
- Human plasma
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Mouse Plasma
- Oryza Sativa
- Sf9 Insect Cell
- Wheat Germ
- Avi
- His
- C
- GST
- His (Fc)
- N/A
- N
- T7|His
- T7
- TEV
- Tag Free
- Involved Pathway
- Protein Function
- Interacting Protein
- FN1 Related Articles
FN1 involved in several pathways and played different roles in them. We selected most pathways FN1 participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with FN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PIK-Akt signaling pathway | SOS1;G6PC;ITGA5;CCND2;FGF2;OSMR;IL4;GHR;FGF7 |
| Focal adhesion | LAMA4;ITGA3B;ITGB5;GRB2A;FYNB;GSK3B;BAD;ACTN3B;LAMC1 |
| ECM-receptor interaction | COL27A1B;ITGAV;ITGA11A;COL1A1;ITGA7;LAMA4;COL6A5;HSPG2;GP1BA |
| Regulation of actin cytoskeleton | CHRM5B;FGD;INSRR;PDGFRA;ITGA10;CYFIP1;ITGAV;EZRB;ITGA5 |
| Bacterial invasion of epithelial cells | CTTN;ITGB1;CTNNA3;GAB1;RAC1;VCL;PIK3CB;CLTC;ARPC2 |
| Amoebiasis | RAB7A;ADCY1;VCL;TNF;ACTN4;IL6;IL1R1;COL4A5;CXCL1 |
| Pathways in cancer | WNT5B;RALGDS;KIT;GNG7;NOS2;BCL2L1;BMP4;FZD5;TCEB1 |
| Proteoglycans in cancer | PRKCB;PRKCA;PDCD4;VTN;TWIST1;HGF;WNT8B;PIK3R1;GAB1 |
| Small cell lung cancer | LAMA2;APAF1;RXRA;RXRB;RB1;MAX;AKT2;BIRC8;PIK3R2 |
FN1 has several biochemical functions, for example, collagen binding, heparin binding, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FN1 itself. We selected most functions FN1 had, and list some proteins which have the same functions with FN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| collagen binding | TLL1;MTAP1A;PDGFB;FN1;DCN;ASPN;MMP13;SPARC;PCOLCE |
| heparin binding | WISP1B;ANG;SERPINA5;CHRD;C6orf25;SERPINA10;WISP1;BMP7;HDGF |
| integrin binding | COL16A1;ADAM2;TIMP2;LAMB1;JAM3;ADAM23;ICAM3;NISCH;PTPN2 |
| peptidase activator activity | CAV1;FN1;MMP14;MMP25;APP;PCOLCE2;CLPX;PSME4B;FBLN1 |
| protease binding | SERPINF2;TIMP1;FURIN;TYSND1;Casp3;CD28;BRCA2;SERPINB6;ITGB1 |
| protein binding | RPL36AL;NPBWR2;Car8;PPFIA2;WDR12;PTPRD;RNF175;C7orf31;LINC00482 |
FN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FN1.
fnbB; heparin
- Q&As
- Reviews
Q&As (6)
Ask a questionIt is expressed in a variety of organs and tissues, including skin, kidneys, cardiovascular system, liver, etc.
FN1 protein is involved in the migration, adhesion and activation of inflammatory cells during the inflammatory response, and plays an important role in the development of inflammation.
Yes, multiple factors have been found to regulate the expression and function of FN1 protein, including transcription factors, growth factors, etc.
FN1 protein is involved in the invasion and metastasis of tumor cells, which can provide matrix support and guide signals to promote the migration and invasion of tumor cells.
This protein is involved in key steps such as fibrosis, angiogenesis and interstitial cell proliferation in the wound healing process, and plays an important role in wound repair.
The protein plays an important role in key steps such as extracellular matrix remodeling, cell adhesion, and directed differentiation of mesenchymal stem cells during tissue repair.
Customer Reviews (3)
Write a reviewThe preservation conditions are wide and the efficiency is high.
Experimental process is convenient, which greatly improves the efficiency of scientific research.
Biological activity of this protein is amazing, and you can see that its production process is very pure, which has a crucial effect on the quality of the product.
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