AIF1
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Official Full Name
allograft inflammatory factor 1
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Overview
This gene is induced by cytokines and interferon. Its protein product is thought to be involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008] -
Synonyms
AIF1; allograft inflammatory factor 1; IBA1; IRT1; AIF-1; IRT-1; protein G1; interferon gamma responsive transcript; ionized calcium-binding adapter molecule 1; allograft inflammatory factor-1 splice variant Hara-1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bovine
- Human
- Mouse
- Pig
- Rat
- Rhesus Macaque
- E. coli
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- Yeast
- C
- His
- GST
- His (Fc)
- Avi
- Myc
- His|GST
- SUMO
- MYC
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- AIF1 Related Articles
AIF1 involved in several pathways and played different roles in them. We selected most pathways AIF1 participated on our site, such as Spinal Cord Injury, which may be useful for your reference. Also, other proteins which involved in the same pathway with AIF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Spinal Cord Injury | NOX4;MBP;GAP43;RTN4R;LILRB3;TNFSF13B;OMG;RTN4;KLK8 |
AIF1 has several biochemical functions, for example, actin filament binding, calcium ion binding, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by AIF1 itself. We selected most functions AIF1 had, and list some proteins which have the same functions with AIF1. You can find most of the proteins on our site.
Function | Related Protein |
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actin filament binding | WIPF2B;MYO3A;CORO1B;USH1C;SHROOM2;PLDN;AIF1L;MAP1S;MYL4 |
calcium ion binding | PADI6;NID1;NCL;KIAA0494;PCDHA9;PRRG1;PCDHB11;MYL9;PLCB2 |
molecular_function | GM2825;SYNGR3B;BCL7A;C1QTNF3;TMX2A;COG5;MUC13B;GLMP;KPRP |
AIF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AIF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AIF1.
HSFY1; PHB
- Q&As
- Reviews
Q&As (14)
Ask a questionYes, AIF1 has been implicated in cardiovascular diseases, particularly in atherosclerosis, a condition in which plaque builds up in the arteries. AIF1 is involved in the activation of macrophages, which play a key role in the development of atherosclerosis. AIF1 expression has been found to be increased in atherosclerotic plaques.
AIF1 has not been widely studied as a potential target for gene therapy. However, it is possible that its role in immune cell activation and inflammation could be harnessed for therapeutic purposes.
AIF1 has been suggested as a potential biomarker for several diseases, including Alzheimer's disease and multiple sclerosis. However, more research is needed to validate its use as a diagnostic biomarker.
Yes, there are genetic variations in the AIF1 gene that have been associated with various diseases. For example, a single nucleotide polymorphism (SNP) in the AIF1 gene has been linked to an increased risk of rheumatoid arthritis, while another SNP has been associated with autoimmune thyroid disease.
There are three known isoforms of AIF1: AIF1α, AIF1β, and AIF1γ. AIF1α is the most well-known isoform and is expressed in macrophages, microglia, and other immune cells. AIF1β is expressed in the thymus and spleen, while AIF1γ is expressed in the testis.
AIF1 has been proposed as a potential biomarker for various diseases, including cancer, autoimmune diseases, and neurodegenerative diseases. However, more research is needed to establish its usefulness as a biomarker and determine the best way to measure AIF1 levels.
AIF1 is a potential target for the development of therapies for various diseases, including Alzheimer's disease, multiple sclerosis, and cancer. It could also be used as a diagnostic biomarker for certain diseases.
Yes, AIF1 is involved in neuroinflammation and neurodegenerative diseases. It is expressed in microglia, the immune cells of the central nervous system (CNS), and plays a role in activating these cells and promoting neuroinflammation. Increased AIF1 expression has been observed in various neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.
Potential therapeutic strategies for targeting AIF1 include developing drugs that inhibit its expression or function, or developing immunomodulatory therapies that modulate immune cell activation more broadly. However, more research is needed to determine the feasibility and safety of these approaches.
AIF1 protein can be detected in cells using various techniques, including immunohistochemistry, immunofluorescence, Western blotting, and flow cytometry. Antibodies that specifically recognize AIF1 can be used to visualize its expression and localization within cells.
AIF1 is a potential target for therapeutic interventions aimed at reducing inflammation in various diseases. However, more research is needed to develop effective therapies that specifically target AIF1.
There are currently no known mutations in the AIF1 gene that cause disease, although genetic variation in the gene may influence susceptibility to certain diseases.
There are currently no drugs that specifically target AIF1, although some drugs that target immune cells, such as corticosteroids and immunosuppressive agents, may indirectly affect AIF1 expression and function.
AIF1 has been found to be overexpressed in several types of cancer, including breast cancer, pancreatic cancer, and esophageal cancer. Its exact role in cancer is not yet fully understood, but it is thought to play a role in tumor progression and metastasis.
Customer Reviews (4)
Write a reviewWhether I require assistance with troubleshooting experimental protocols or guidance on data analysis, their reliable and prompt support will undoubtedly prove invaluable in finding solutions.
The AIF1 protein displays exceptional quality and is precisely aligned with my experimental requirements.
Its reliability and the manufacturer's expertise will undoubtedly contribute to the success and significance of my research.
the AIF1 protein's remarkable quality and the manufacturer's excellent technical support make it an ideal choice to fulfill my experimental needs.
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