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Gabra1

  • Official Full Name

    gamma-aminobutyric acid (GABA) A receptor, alpha 1

  • Overview

    This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms

    GABRA1; gamma-aminobutyric acid (GABA) A receptor, alpha 1; EJM; ECA4; EJM5; EIEE19; gamma-aminobutyric acid receptor subunit alpha-1; GABA(A) receptor, alpha 1; GABA(A) receptor subunit alpha-1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GABRA1-13092H Recombinant Human GABRA1, GST-tagged E.coli GST 20-260a.a.
Human GABRA1-6067HCL Recombinant Human GABRA1 293 Cell Lysate HEK293 N/A
Human GABRA1-4635H Recombinant Human GABRA1 Protein, GST-tagged Wheat Germ GST
Human GABRA1-5182HF Recombinant Full Length Human GABRA1 Protein, GST-tagged In Vitro Cell Free System GST 456 amino acids
Human GABRA1-2935H Recombinant Human GABRA1 protein, His-tagged E.coli His 28-251aa
Mouse GABRA1-6144M Recombinant Mouse GABRA1 Protein Mammalian Cell His
Mouse GABRA1-3427M-B Recombinant Mouse GABRA1 Protein Pre-coupled Magnetic Beads HEK293
Mouse GABRA1-3427M Recombinant Mouse GABRA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat GABRA1-2444R Recombinant Rat GABRA1 Protein Mammalian Cell His
Rat GABRA1-2100R Recombinant Rat GABRA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat GABRA1-2100R-B Recombinant Rat GABRA1 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey GABRA1-533C Recombinant Cynomolgus GABRA1 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey GABRA1-278C Recombinant Cynomolgus Monkey GABRA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey GABRA1-278C-B Recombinant Cynomolgus Monkey GABRA1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque GABRA1-1792R Recombinant Rhesus monkey GABRA1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque GABRA1-1613R-B Recombinant Rhesus Macaque GABRA1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque GABRA1-1613R Recombinant Rhesus Macaque GABRA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish GABRA1-4685Z Recombinant Zebrafish GABRA1 Mammalian Cell His
Chicken GABRA1-5891C Recombinant Chicken GABRA1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Gabra1 Related Articles
  • Gabra1 Related Research Area

Gabra1 involved in several pathways and played different roles in them. We selected most pathways Gabra1 participated on our site, such as Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with Gabra1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Neuroactive ligand-receptor interactionP2RX2;MLNR;TAAR64;GABRG1;GABRB3;F2RL1.1;CRHR2;MTNR1AA;GLRA2
Retrograde endocannabinoid signalingMAPK3;GABRD;MAPK12;GNB3;RIMS1;GNB4;GABRB1;PLCB2;GABRA4
GABAergic synapsePLCL1;GABBR1;GABARAPL2;GNB2;GABARAPL1;GNGT2;GABBR2;GABRG1;PRKACG
Nicotine addictionGABRB2;GABRA2;GABRD;GABRG3;SLC17A7;GABRB3;GABRB1;GABRR3;GABRR1

Gabra1 has several biochemical functions, for example, contributes_to GABA receptor activity, GABA-A receptor activity, contributes_to benzodiazepine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Gabra1 itself. We selected most functions Gabra1 had, and list some proteins which have the same functions with Gabra1. You can find most of the proteins on our site.

Function Related Protein
contributes_to GABA receptor activity
GABA-A receptor activityGABRB1;GABRA1;GABRA6A;GABRR3;GABRG2;GABRB2;GABRE;GABRD;GABRB3
contributes_to benzodiazepine receptor activityGABRA5;GABRG3;GABRA6A;GABRG1;GABRA1;GABRE
chloride channel activitySLC26A5;GABRG3;GABRR1;CLCA5;CLIC5B;CLCN7;GABRE;SLC26A4;CLCN5
drug bindingTOP2A;MT2A;TLR7;FOLR2;PPP3CB;RARB;PPARD;Alb;CNR1
inhibitory extracellular ligand-gated ion channel activityGABRA3;GABRA6;GABRE;GABRA4;GABRA2;GABRA6A;GABRA5;GABRA1;GABRG3

Gabra1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Gabra1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Gabra1.

Arfgef2

Swanson, AM; Allen, AG; et al. GABA(A)alpha 1-Mediated Plasticity in the Orbitofrontal Cortex Regulates Context-Dependent Action Selection. NEUROPSYCHOPHARMACOLOGY 40:1027-1036(2015).
Park, YG; Choi, JH; et al. Heterogeneity of tremor mechanisms assessed by tremor-related cortical potential in mice. MOLECULAR BRAIN 8:-(2015).
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