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GABRB1

  • Official Full Name

    gamma-aminobutyric acid (GABA) A receptor, beta 1

  • Overview

    The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia.
  • Synonyms

    GABRB1; gamma-aminobutyric acid (GABA) A receptor, beta 1; gamma-aminobutyric acid receptor subunit beta-1; GABA(A) receptor; beta 1; GABA(A) receptor, beta 1; GABA(A) receptor subunit beta-1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GABRB1-13097H Recombinant Human GABRB1, His-tagged E.coli His 330-440a.a.
Human GABRB1-6062HCL Recombinant Human GABRB1 293 Cell Lysate HEK293 N/A
Human GABRB1-4645H Recombinant Human GABRB1 Protein, GST-tagged Wheat Germ GST
Human GABRB1-1548H Recombinant Human GABRB1 Protein, His-tagged E.coli N-His His26-Tyr245
Mouse GABRB1-6149M Recombinant Mouse GABRB1 Protein Mammalian Cell His
Mouse GABRB1-3430M-B Recombinant Mouse GABRB1 Protein Pre-coupled Magnetic Beads HEK293
Mouse GABRB1-3430M Recombinant Mouse GABRB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat GABRB1-2448R Recombinant Rat GABRB1 Protein Mammalian Cell His
Rat GABRB1-2104R Recombinant Rat GABRB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat GABRB1-2104R-B Recombinant Rat GABRB1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GABRB1 Related Articles
  • GABRB1 Related Research Area

GABRB1 involved in several pathways and played different roles in them. We selected most pathways GABRB1 participated on our site, such as Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, Serotonergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GABRB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Neuroactive ligand-receptor interactionNPBWR2;TAAR7D;TAAR12E;TAAR14A;RXFP2A;PTH1RA;GPR156;TAAR12F;GRIN2A
Retrograde endocannabinoid signalingGRIA4;PRKACA;GNAI2;MAPK11;PRKCA;SLC17A6;ITPR1;RIMS1;SLC17A8
Serotonergic synapseHTR7;GNG10;HTR1B;PLA2G4D;APP;PLCB2;MAPK1;GNG13;HTR5A
GABAergic synapseGABBR1;GABRR3;GNG11;GLUL;NSF;GNB2;GNB3;GNAI1;SRC
Nicotine addictionGABRA2;GABRP;GABRB1;GRIA2;GABRD;GRIA1;GABRA1;SLC17A8;GABRR1

GABRB1 has several biochemical functions, for example, GABA receptor binding, GABA-A receptor activity, contributes_to chloride channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GABRB1 itself. We selected most functions GABRB1 had, and list some proteins which have the same functions with GABRB1. You can find most of the proteins on our site.

Function Related Protein
GABA receptor bindingGABRG1;GABRA5;PLCL2;GABARAPL1;GABARAPA;JAKMIP1;PLCL1;GABARAPL2;PPP2CA
GABA-A receptor activityGABRG2;GABRZ;GABRR2;GABRA6A;GABRD;GABRE;GABRB3;GABRA1;GABRR3
contributes_to chloride channel activityBEST1;BEST4;GABRZ;GABRB2;GABRR2A;GABRQ;GABRB3;GABRR3A;GABRR2
contributes_to extracellular ligand-gated ion channel activityGABRR2A;GABRB1;GABRR3A;GABRB3;GABRR2;GABRB2;GABRQ;GABRZ
ligand-gated ion channel activityCHRNA5;CNGA3;CHRNB4;GABRB1;CHRNB1;CLCA2;CHRNA4;Chrng;TRPA1A

GABRB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GABRB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GABRB1.

FKBP5; NEUROD4; NOD1; q96be0_human

Zhu, B; Chen, CS; et al. The GABRB1 gene is associated with thalamus volume and modulates the association between thalamus volume and intelligence. NEUROIMAGE 102:756-763(2014).
Srivastava, S; Cohen, J; et al. A Novel Variant in GABRB2 Associated with Intellectual Disability and Epilepsy. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 164A:2914-2921(2014).
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