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GABRG1

  • Official Full Name

    gamma-aminobutyric acid (GABA) A receptor, gamma 1

  • Overview

    The protein encoded by this gene belongs to the ligand-gated ionic channel family. It is an integral membrane protein and plays an important role in inhibiting neurotransmission by binding to the benzodiazepine receptor and opening an integral chloride channel. This gene is clustered with three other family members on chromosome 4.
  • Synonyms

    GABRG1; gamma-aminobutyric acid (GABA) A receptor, gamma 1; gamma-aminobutyric acid receptor subunit gamma-1; GABA(A) receptor; gamma; gamma-1 polypeptide; GABA(A) receptor, gamma; GABA(A) receptor subunit gamma-1; MGC33838; DKFZp686H2042;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GABRG1-13102H Recombinant Human GABRG1, GST-tagged E.coli GST 38-271a.a.
Human GABRG1-6058HCL Recombinant Human GABRG1 293 Cell Lysate HEK293 N/A
Human GABRG1-4650H Recombinant Human GABRG1 Protein, GST-tagged Wheat Germ GST
Human GABRG1-5201HF Recombinant Full Length Human GABRG1 Protein, GST-tagged In Vitro Cell Free System GST 465 amino acids
Mouse GABRG1-6154M Recombinant Mouse GABRG1 Protein Mammalian Cell His
Mouse GABRG1-3433M Recombinant Mouse GABRG1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse GABRG1-3433M-B Recombinant Mouse GABRG1 Protein Pre-coupled Magnetic Beads HEK293
Rat GABRG1-2452R Recombinant Rat GABRG1 Protein Mammalian Cell His
Rat GABRG1-2108R-B Recombinant Rat GABRG1 Protein Pre-coupled Magnetic Beads HEK293
Rat GABRG1-2108R Recombinant Rat GABRG1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GABRG1 Related Articles
  • GABRG1 Related Research Area

GABRG1 involved in several pathways and played different roles in them. We selected most pathways GABRG1 participated on our site, such as Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GABRG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Neuroactive ligand-receptor interactionGLRA1;P2RX1;GHRA;GALR3;GHRHR;GHR;HTR2B;TAAR14I;PTGER2A
Retrograde endocannabinoid signalingGABRA4;GNAI2;PRKACA;RIMS1;GNAO1;GABRG3;GABRB2;GRIA2;MAPK13
GABAergic synapseGABRR3;GAD1;GABRA4;GLUL;GLS;GABRP;PRKACA;GNG5;GABBR2
Nicotine addictionGRIN3A;GABRB1;GABRR3;GABRQ;GRIA3;GRIA2;GABRA2;GABRB3;SLC17A6

GABRG1 has several biochemical functions, for example, GABA receptor binding, contributes_to GABA-A receptor activity, contributes_to benzodiazepine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GABRG1 itself. We selected most functions GABRG1 had, and list some proteins which have the same functions with GABRG1. You can find most of the proteins on our site.

Function Related Protein
GABA receptor bindingTRAK1;PLCL1;AKAP5;MAF1;GABARAP;GABARAPL2;PLCL2;GABRA5;GABRB1
contributes_to GABA-A receptor activityGABRG2;GABRA6A;GABRP;GABRG1;GABRA3;GABRG3;GABRQ;GABRZ;GABRR2A
contributes_to benzodiazepine receptor activityGABRG3;GABRA5;GABRA1;GABRG1;GABRE;GABRA6A
chloride channel activitySLC26A3.1;CLIC2;SLC1A4;CLCA2;SLC26A5;CLIC5;GABRA2;GABRA4;TTYH3
inhibitory extracellular ligand-gated ion channel activityGABRA5;GABRA1;GABRA4;GABRB2;GABRA6;GABRA6A;GABRA3;GABRA2;GABRG1

GABRG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GABRG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GABRG1.

Wang, XP; Cheng, ZY; et al. GABA(B) receptors are expressed in human aortic smooth muscle cells and regulate the intracellular Ca2+ concentration. HEART AND VESSELS 30:249-257(2015).
Blankenburg, S; Balfanz, S; et al. Cockroach GABA(B) receptor subtypes: Molecular characterization, pharmacological properties and tissue distribution. NEUROPHARMACOLOGY 88:134-144(2015).
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