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GABRG3

  • Official Full Name

    gamma-aminobutyric acid (GABA) A receptor, gamma 3

  • Overview

    This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the;mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of;these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors;are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. The protein;encoded by this gene is a gamma subunit, which contains the benzodiazepine binding site. Two transcript variants;encoding distinct isoforms have been found for this gene.
  • Synonyms

    GABRG3; gamma-aminobutyric acid (GABA) A receptor, gamma 3; gamma-aminobutyric acid receptor subunit gamma-3; GABA(A) receptor; GABA(A) receptor subunit gamma 3; GABR G3; GABRG 3; Gamma aminobutyric acid (GABA) A receptor gamma 3; Gamma aminobutyric acid A receptor gamma 3; Gamma aminobutyric acid receptor subunit gamma 3; GABA(A) receptor subunit gamma-3;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GABRG3-6056HCL Recombinant Human GABRG3 293 Cell Lysate HEK293 N/A
Mouse GABRG3-6156M Recombinant Mouse GABRG3 Protein Mammalian Cell His
Mouse GABRG3-3435M-B Recombinant Mouse GABRG3 Protein Pre-coupled Magnetic Beads HEK293
Mouse GABRG3-3435M Recombinant Mouse GABRG3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat GABRG3-2454R Recombinant Rat GABRG3 Protein Mammalian Cell His
Rat GABRG3-2110R Recombinant Rat GABRG3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat GABRG3-2110R-B Recombinant Rat GABRG3 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GABRG3 Related Articles
  • GABRG3 Related Research Area

GABRG3 involved in several pathways and played different roles in them. We selected most pathways GABRG3 participated on our site, such as Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GABRG3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Neuroactive ligand-receptor interactionTAAR12F;GRIK3;FPR2;S1PR2;ADORA1;TRHR2;GABRG1;TAAR13B;GABRR1
Retrograde endocannabinoid signalingGABRP;GNG8;GNG7;GNB4;PRKCB;MAPK11;GABRG1;GNG12;GNGT1
GABAergic synapseGNAI1;SRC;GNAI3;GNG4;GABRR2;GNG12;GABARAPL1;GNG10;GLS
Nicotine addictionGABRA4;GRIN3B;GABRE;GABRB3;CHRNA6;SLC17A7;GABRA3;GABRG3;GRIA4

GABRG3 has several biochemical functions, for example, contributes_to GABA-A receptor activity, contributes_to benzodiazepine receptor activity, chloride channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GABRG3 itself. We selected most functions GABRG3 had, and list some proteins which have the same functions with GABRG3. You can find most of the proteins on our site.

Function Related Protein
contributes_to GABA-A receptor activityGABRA5;GABRG1;GABRA3;GABRA2;GABRA6A;GABRA6;GABRR3A;GABRQ;GABRA4
contributes_to benzodiazepine receptor activityGABRA6A;GABRA1;GABRG1;GABRA5;GABRG3;GABRE
chloride channel activityCLICA;SLC26A2;ANO2;CLIC4;GABRA3;SLC26A5;SLC26A7;SLC26A3;FXYD3
inhibitory extracellular ligand-gated ion channel activityGABRA1;GABRE;GABRA3;GABRA4;GABRA5;GABRA6;GABRG3;GABRA2;GABRA6A

GABRG3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GABRG3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GABRG3.

Wang, XP; Cheng, ZY; et al. GABA(B) receptors are expressed in human aortic smooth muscle cells and regulate the intracellular Ca2+ concentration. HEART AND VESSELS 30:249-257(2015).
Cheng, ZY; Wang, XP; et al. GABA(B1) AND GABA(B2) RECEPTOR SUBUNITS CO-EXPRESSED IN CULTURED HUMAN RPE CELLS REGULATE INTRACELLULAR CA(2+) VIA G(I/O)-PROTEIN AND PHOSPHOLIPASE C PATHWAYS. NEUROSCIENCE 280:254-261(2014).
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