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GAN

Official Full Name

gigaxonin
Overview

This gene encodes a member of the cytoskeletal BTB/kelch (Broad-Complex, Tramtrack and Bric a brac) repeat family. The encoded protein plays a role in neurofilament architecture and is involved in mediating the ubiquitination and degradation of some proteins. Defects in this gene are a cause of giant axonal neuropathy (GAN). [provided by RefSeq, Oct 2008]
Synonyms

GAN; gigaxonin; GAN1; KLHL16; kelch-like protein 16; kelch-like family member 16;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
His|T7
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GAN-13149H	Recombinant Human GAN, His-tagged	E.coli	His	248-597a.a.	$319 / 25ug
Human	GAN-287HCL	Recombinant Human GAN lysate	HEK293	N/A		Inquiry
Human	GAN-5376HF	Recombinant Full Length Human GAN Protein, GST-tagged	In Vitro Cell Free System	GST	597 amino acids	Inquiry
Human	GAN-1614H	Recombinant Human GAN protein, His & T7-tagged	E.coli	His/T7	Cys30~Gly326 (Accession # Q9H2C0)	Inquiry
Human	GAN-4717H	Recombinant Human GAN Protein, GST-tagged	Wheat Germ	GST		Inquiry
Mouse	GAN-6202M	Recombinant Mouse GAN Protein	Mammalian Cell	His		Inquiry
Mouse	GAN-3463M	Recombinant Mouse GAN Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	GAN-3463M-B	Recombinant Mouse GAN Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
GAN Related Articles

GAN involved in several pathways and played different roles in them. We selected most pathways GAN participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &amp, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with GAN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Adaptive Immune System	FBXO17;MKRN1;KIF18A;NRG2A;PTBP3;CD300LF;ICAM4;CTSB;KIF2B
Antigen processing: Ubiquitination &amp	FBXO3;RNF111;UBE2J2;RNF14;ASB11;DZIP3;PJA1;UBR1;RNF25
Proteasome degradation	RNF14;KLHL21;ARIH2;ASB4;TRIM63;VPRBP;UBE2U;UBE2V1;ASB13
Class I MHC mediated antigen processing &amp	TRIM9;ASB6;ASB14;FBXO27;CD207;CTSS;NPEPPS;VPRBP;ASB8
presentation	ASB2;UFL1;LRRC41;CTSL2;CTSL1;ATG7;MKRN1;ASB14;WWP1
Immune System	PIK3AP1;CFHL3;TRIM11;CLEC2B;LILRA3;POLR3F;BLMH;SIGLEC11;LAT2

GAN has several biochemical functions, for example, molecular_function, protein binding, contributes_to ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GAN itself. We selected most functions GAN had, and list some proteins which have the same functions with GAN. You can find most of the proteins on our site.

Function	Related Protein
molecular_function	LRRC14B;Actl10;CCDC15;C1orf123;DEFB20;DNAJB13;REG3D;GM4201;FAM177A
protein binding	PFN2;RHO;EPHA4;ADAM33;UBAC1;TIPRL;UBL7;MEGF6;DPEP1
contributes_to ubiquitin-protein transferase activity	KLHL3;DDB2;PHOSPHO2-KLHL23;KLHL28;KLHL24A;KLHL24;IPP;KBTBD7;KLHL23

GAN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GAN here. Most of them are supplied by our site. Hope this information will be useful for your research of GAN.

UBA1; MAP1B; TBCB; b4dyc6_human; HSP90AB1; SFN; ATG16L1; NUDCD3; ATG16L1

Wen, PY; Li, DY; et al. Identification of Degradation Mechanisms Based on Thermal Characteristics of InGaN/GaN Laser Diodes. IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS 21:-(2015).

Hwang, HY; Choi, SB; et al. Combined Effect of Carrier Localization and Polarity in InxGa1-xN/GaN Quantum Wells. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 15:5933-5936(2015).