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GAP43

  • Official Full Name

    Gap43 growth associated protein 43

  • Overview

    GAP43 is a phosphoprotein of the presynaptic membrane involved in synaptic reorganization and neural development. It is present at high levels in neuronal growth cones during development and axonal regeneration. GAP43 is normally produced by neurons during developmental growth and axonal regeneration, but it is also expressed in specific regions of the normal adult nervous system.
  • Synonyms

    GAP43; growth associated protein 43; neuromodulin; growth-associated protein 43; axonal membrane protein GAP-43; growth accentuating protein 43; calmodulin-binding protein P-57; brain abundant, membrane attached signal protein 2; B-50; Basp2; GAP-43;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GAP43-6831H Recombinant Human Growth Associated Protein 43, His-tagged E.coli His 1-238aa
Human GAP43-28977TH Recombinant Human GAP43 Wheat Germ N/A 238 amino acids
Human GAP43-016H Recombinant Human GAP43 protein, His-tagged HEK293 His Met1-Ala238
Human GAP43-1911HCL Recombinant Human GAP43 cell lysate Human Cell N/A
Human GAP43-4723H Recombinant Human GAP43 Protein, GST-tagged Wheat Germ GST
Human GAP43-2730H Recombinant Human GAP43 Protein (Met1-Ala238), His tagged E.coli His Met1-Ala238
Human GAP43-1251H Recombinant Human GAP43 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human GAP43-178HF Recombinant Full Length Human GAP43 Protein In Vitro Cell Free System 238 amino acids
Human GAP43-5416HF Recombinant Full Length Human GAP43 Protein, GST-tagged In Vitro Cell Free System GST 238 amino acids
Mouse Gap43-6817M Recombinant Mouse Gap43 protein, His & T7-tagged E.coli His/T7 Thr8~Ala228 (Accession # P06837)
Mouse GAP43-6205M Recombinant Mouse GAP43 Protein Mammalian Cell His
Mouse GAP43-3464M-B Recombinant Mouse GAP43 Protein Pre-coupled Magnetic Beads HEK293
Mouse GAP43-3464M Recombinant Mouse GAP43 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Gap43-3149M Recombinant Mouse Gap43 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat GAP43-2475R Recombinant Rat GAP43 Protein Mammalian Cell His
Rat Gap43-6818R Recombinant Rat Gap43 protein, His & T7-tagged E.coli His/T7 Thr8~Ala226 (Accession # P07936)
Rat GAP43-2131R Recombinant Rat GAP43 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat GAP43-2131R-B Recombinant Rat GAP43 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey GAP43-536C Recombinant Cynomolgus GAP43 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey GAP43-281C-B Recombinant Cynomolgus Monkey GAP43 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey GAP43-281C Recombinant Cynomolgus Monkey GAP43 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish GAP43-8927Z Recombinant Zebrafish GAP43 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GAP43 Related Articles

GAP43 involved in several pathways and played different roles in them. We selected most pathways GAP43 participated on our site, such as Glial Cell Differentiation, N-cadherin signaling events, Spinal Cord Injury, which may be useful for your reference. Also, other proteins which involved in the same pathway with GAP43 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glial Cell DifferentiationGAP43;MBP;TPPP;CNP;PLP1
N-cadherin signaling eventsCNR1;GAP43
Spinal Cord InjuryGAP43;AIF1;LGALS3;RGMA;KLK8;LILRB3;RTN4R;MBP;OMG

GAP43 has several biochemical functions, for example, calmodulin binding, lysophosphatidic acid binding, phosphatidylinositol phosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GAP43 itself. We selected most functions GAP43 had, and list some proteins which have the same functions with GAP43. You can find most of the proteins on our site.

Function Related Protein
calmodulin bindingKCNN2;NETO2;MYO1D;AKAP5;EPB41;PPP3CC;SLC14A2;PPP3CA;CAMK1GB
lysophosphatidic acid bindingLPAR1;GAP43;VIL1
phosphatidylinositol phosphate bindingGAP43;SNX11;RPH3A;ANKFY1;RNF34;PLCD1
phosphatidylserine bindingOSBPL5;THBS1;CPNE6;ANXA9;SCIN;RASGRP1;SDPR;OSBPL10;AXL
protein bindingAP1M2;PDIA2;FANCB;TP53BP1;SEC63;CD209;ILF3;CCDC68;BCL3

GAP43 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GAP43 here. Most of them are supplied by our site. Hope this information will be useful for your research of GAP43.

PRKCD

Bystrom, S; Ayoglu, B; et al. Affinity Proteomic Profiling of Plasma, Cerebrospinal Fluid, and Brain Tissue within Multiple Sclerosis. JOURNAL OF PROTEOME RESEARCH 13:4607-4619(2014).
Sanna, MD; Quattrone, A; et al. The RNA-binding protein HuD promotes spinal GAP43 overexpression in antiretroviral-induced neuropathy. EXPERIMENTAL NEUROLOGY 261:343-353(2014).
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