gas8
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  • Official Full Name
  • growth arrest-specific 8
  • Background
  • This gene includes 11 exons spanning 25 kb and maps to a region of chromosome 16 that is sometimes deleted in breast and prostrate cancer. The second intron contains an apparently intronless gene, C16orf3, that is transcribed in the opposite orientation. This gene is a putative tumor suppressor gene.
  • Synonyms
  • GAS8; growth arrest-specific 8; GAS11, growth arrest specific 11; growth arrest-specific protein 8; Growth arrest specific protein 8; MGC138326; GAS 11; GAS 8; GAS11; Growth arrest specific 11; Growth arrest specific 8; Growth arrest specific protein 11; GAS-8; GAS-11; growth arrest-specific 11; growth arrest-specific protein 11
Cat.#:GAS8-1329HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GAS8 Protein, His-tagged
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Cat.#:GAS8-13164HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GAS8, GST-tagged
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Cat.#:GAS8-2479RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GAS8 Protein
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Cat.#:GAS8-1815RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey GAS8 Protein, His-tagged
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Cat.#:GAS8-4996CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GAS8
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Cat.#:GAS8-10035ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GAS8
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Cat.#:GAS8-6015HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GAS8 293 Cell Lysate
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Involved Pathway

GAS8 involved in several pathways and played different roles in them. We selected most pathways GAS8 participated on our site, such as Activation of SMO, Hedgehog on state, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GAS8 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activation of SMO
ADRBK1; EFCAB7; EVC2; CSNK1A1; KIF3A; GAS8; CDON; BOC; IQCE; EVC
Hedgehog on state
IFT172; EFCAB7; SPOPL; RPGRIP1L; DZIP1; IQCE; KIF7; EVC; CDON; GPR161
Signal Transduction
RHOF; BCL9L; CCL35.2; RGR; SHRPRBCK1R; OR7D2; RLN3A; CLIP3; RTN4; RBBP5
Signaling by Hedgehog
WDR35; IFT88; GPR161; BBS13; IFT172; NOTUM; KIF7; CDON; HHAT; SPOPL

Protein Function

GAS8 has several biochemical functions, for example, Rab GTPase binding, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by GAS8 itself. We selected most functions GAS8 had, and list some proteins which have the same functions with GAS8. You can find most of the proteins on our site.
Function
Related Protein
Function Rab GTPase binding
Related Protein ANKFY1; MYO5A; RABGGTA; RABGEF1; SYTL2; GOLGA5; ZFP652; RAB11FIP1; STXBP5L; RGP1
Function molecular_function
Related Protein SAP130A; GM8660; WSCD2; GM2506; TMEM185; Mamdc4; TMEM144B; BTNL3; SBNO1; C1QL3B

Interacting Protein

GAS8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GAS8 here. Most of them are supplied by our site. Hope this information will be useful for your research of GAS8.
CIAO1; IQCB1

GAS8 Related Articles

Horani, A; Brody, SL; et al. CCDC65 Mutation Causes Primary Ciliary Dyskinesia with Normal Ultrastructure and Hyperkinetic Cilia. PLOS ONE 8:-(2013).
Evron, T; Philipp, M; et al. Growth Arrest Specific 8 (Gas8) and G Protein-coupled Receptor Kinase 2 (GRK2) Cooperate in the Control of Smoothened Signaling. JOURNAL OF BIOLOGICAL CHEMISTRY 286:27676-27686(2011).