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GAS8

  • Official Full Name

    growth arrest-specific 8

  • Overview

    This gene includes 11 exons spanning 25 kb and maps to a region of chromosome 16 that is sometimes deleted in breast and prostrate cancer. The second intron contains an apparently intronless gene, C16orf3, that is transcribed in the opposite orientation. This gene is a putative tumor suppressor gene.
  • Synonyms

    GAS8; growth arrest-specific 8; GAS11, growth arrest specific 11; growth arrest-specific protein 8; Growth arrest specific protein 8; MGC138326; GAS 11; GAS 8; GAS11; Growth arrest specific 11; Growth arrest specific 8; Growth arrest specific protein 11; GAS-8; GAS-11; growth arrest-specific 11; growth arrest-specific protein 11;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GAS8-13164H Recombinant Human GAS8, GST-tagged E.coli GST 130-478a.a.
Human GAS8-6015HCL Recombinant Human GAS8 293 Cell Lysate HEK293 N/A
Human GAS8-1329H Recombinant Human GAS8 Protein, His-tagged E.coli His
Human GAS8-2193H Recombinant Human GAS8 Protein, His-tagged E.coli N-His Met1-Met258
Mouse Gas8-1565M Recombinant Mouse Gas8 Protein, His-tagged E.coli N-His Met1-Thr478
Rat GAS8-2479R Recombinant Rat GAS8 Protein Mammalian Cell His
Rat GAS8-2135R-B Recombinant Rat GAS8 Protein Pre-coupled Magnetic Beads HEK293
Rat GAS8-2135R Recombinant Rat GAS8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque GAS8-1815R Recombinant Rhesus monkey GAS8 Protein, His-tagged Mammalian Cell His
Rhesus Macaque GAS8-1636R-B Recombinant Rhesus Macaque GAS8 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque GAS8-1636R Recombinant Rhesus Macaque GAS8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish GAS8-10035Z Recombinant Zebrafish GAS8 Mammalian Cell His
Chicken GAS8-4996C Recombinant Chicken GAS8 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GAS8 Related Articles

GAS8 involved in several pathways and played different roles in them. We selected most pathways GAS8 participated on our site, such as Activation of SMO, Hedgehog on state, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GAS8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activation of SMOSETD6;IQCE;EVC2;BOC;CSNK1A1;CDON;EFCAB7;ADRBK1;EVC
Hedgehog on stateSPOP;MKS1;KIF7;KIF3A;SPOPL;EVC2;CDC73;GAS8;RPGRIP1L
Signal TransductionFAM13A;FMNL1;GRK7;NMS;OR7D2;EMR4;FSTB;MLN;EFCAB7
Signaling by HedgehogCDC73;SPOP;INTU;KIF7;EVC2;CDON;TTC21B;SCUBE2;GPR161

GAS8 has several biochemical functions, for example, Rab GTPase binding, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by GAS8 itself. We selected most functions GAS8 had, and list some proteins which have the same functions with GAS8. You can find most of the proteins on our site.

Function Related Protein
Rab GTPase bindingCCDC64;TMEM127;ODF2;Fert2;STX4A;RAB11FIP1;RABGEF1;ANKFY1;HPS6
molecular_functionTOMM40L;INO80DB;SNCGA;CCDC149A;GAS8;EVA1BB;GM166;TMEFF2;TSPAN3B

GAS8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GAS8 here. Most of them are supplied by our site. Hope this information will be useful for your research of GAS8.

CIAO1; IQCB1

Horani, A; Brody, SL; et al. CCDC65 Mutation Causes Primary Ciliary Dyskinesia with Normal Ultrastructure and Hyperkinetic Cilia. PLOS ONE 8:-(2013).
Evron, T; Philipp, M; et al. Growth Arrest Specific 8 (Gas8) and G Protein-coupled Receptor Kinase 2 (GRK2) Cooperate in the Control of Smoothened Signaling. JOURNAL OF BIOLOGICAL CHEMISTRY 286:27676-27686(2011).
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