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GBE1

  • Official Full Name

    glucan (1,4-alpha-), branching enzyme 1

  • Overview

    The protein encoded by this gene is a glycogen branching enzyme that catalyzes the transfer of alpha-1,4-linked glucosyl units from the outer end of a glycogen chain to an alpha-1,6 position on the same or a neighboring glycogen chain. Branching of the chains is essential to increase the solubility of the glycogen molecule and, consequently, in reducing the osmotic pressure within cells. Highest level of this enzyme are found in liver and muscle. Mutations in this gene are associated with glycogen storage disease IV (also known as Andersens disease).
  • Synonyms

    GBE1; glucan (1,4-alpha-), branching enzyme 1; 1,4-alpha-glucan-branching enzyme; Andersen disease; glycogen branching enzyme; glycogen storage disease type IV; 1; 1,4 alpha glucan branching enzyme; 4-alpha-glucan-branching enzyme; amylo (1,4 to 1,6) transglucosidase; amylo (1,4 to 1,6) transglycosylase; Brancher enzyme; GBE 1; GBE; gGlucan (1,4 alpha ), branching enzyme 1; GLGB_HUMAN; Glucan (1,4 alpha) branching enzyme; Glycogen-branching enzyme; OTTHUMP00000213788; OTTHUMP00000213833; amylo-(1,4 to 1,6) transglucosidase; amylo-(1,4 to 1,6) transglycosylase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GBE1-28988TH Recombinant Human GBE1 Wheat Germ N/A 702 amino acids
Human GBE1-28989TH Recombinant Human GBE1 Wheat Germ N/A 98 amino acids
Human GBE1-5999HCL Recombinant Human GBE1 293 Cell Lysate HEK293 N/A
Human GBE1-967H Recombinant Human GBE1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human GBE1-4771H Recombinant Human GBE1 Protein, GST-tagged Wheat Germ GST
Human GBE1-1322H Recombinant Human GBE1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human GBE1-187HF Recombinant Full Length Human GBE1 Protein In Vitro Cell Free System 702 amino acids
Human GBE1-967H-B Recombinant Human GBE1 Protein Pre-coupled Magnetic Beads HEK293
Human GBE1-2146HFL Recombinant Full Length Human GBE1 Protein, C-Flag-tagged Mammalian cells Flag
Human GBE1-5520HF Recombinant Full Length Human GBE1 Protein, GST-tagged In Vitro Cell Free System GST 702 amino acids
Mouse GBE1-6238M Recombinant Mouse GBE1 Protein Mammalian Cell His
Mouse Gbe1-3167M Recombinant Mouse Gbe1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse GBE1-3494M-B Recombinant Mouse GBE1 Protein Pre-coupled Magnetic Beads HEK293
Mouse GBE1-3494M Recombinant Mouse GBE1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque GBE1-1818R Recombinant Rhesus monkey GBE1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque GBE1-1639R-B Recombinant Rhesus Macaque GBE1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque GBE1-1639R Recombinant Rhesus Macaque GBE1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GBE1 Related Articles

GBE1 involved in several pathways and played different roles in them. We selected most pathways GBE1 participated on our site, such as Starch and sucrose metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GBE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Starch and sucrose metabolismUGT1A6;ENPP3;UGT2A2;UGT1A9;UGP2;AGLA;UGP2A;UGT2B15;TREH
Metabolic pathwaysSYNJ1;CYP2B19;AGL;AMDHD1;UGT1A6B;ATP6V0A1;INPP4A;B3GALT2;GCSHA

GBE1 has several biochemical functions, for example, 1,4-alpha-glucan branching enzyme activity, cation binding, hydrolase activity, hydrolyzing O-glycosyl compounds. Some of the functions are cooperated with other proteins, some of the functions could acted by GBE1 itself. We selected most functions GBE1 had, and list some proteins which have the same functions with GBE1. You can find most of the proteins on our site.

Function Related Protein
1,4-alpha-glucan branching enzyme activity
cation bindingPPM1AB;Amy1;PPM1LB;SLC3A2B;GBE1;SLC3A1;PPM1E;SLC3A2A;PPM1BB
hydrolase activity, hydrolyzing O-glycosyl compoundsLCTLA;CHIA.2;LCTLB;LCTL;Chil3;ABHD10;CHIA.1;GBE1;GNE

GBE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GBE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GBE1.

TRDMT1; PGD; EPHB3; PRMT6; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; PRICKLE3; OAZ1; Kctd5; KIFAP3; Cdc20; SETD4; VAPA; Rhoa

Bit-Ivan, EN; Lee, KH; et al. Adult polyglucosan body disease with GBE1 haploinsufficiency and concomitant frontotemporal lobar degeneration. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY 40:778-782(2014).
Zmasek, CM; Godzik, A; et al. Phylogenomic analysis of glycogen branching and debranching enzymatic duo. BMC EVOLUTIONARY BIOLOGY 14:-(2014).
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