GBP2 Protein, guanylate binding protein 2, interferon-inducible


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Official Full Name guanylate binding protein 2, interferon-inducible
Background Interferons are cytokines that have antiviral effects and inhibit tumor cell proliferation. They induce a large number of genes in their target cells, including those coding for the guanylate-binding proteins (GBPs). GBPs are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP). The protein encoded by this gene is a GTPase that converts GTP to GDP and GMP.
Synonyms GBP2; guanylate binding protein 2, interferon-inducible; interferon-induced guanylate-binding protein 2; GBP 2; GTP binding protein 2; Guanine nucleotide binding protein 2; Guanylate binding protein 2 interferon inducible; HuGBP 2; HuGBP2; GBP-2; huGBP-2; GTP-binding protein 2; guanine nucleotide-binding protein 2
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GBP2-13181H Recombinant Human GBP2, GST-tagged E.coli GST
    Human GBP2-1328H Recombinant Human GBP2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human GBP2-1337HCL Recombinant Human GBP2 cell lysate Human Cell N/A
    Human GBP2-1688H Recombinant Human GBP2 protein, His & T7-tagged E.coli His/T7
    Human GBP2-4777H Recombinant Human GBP2 Protein, GST-tagged Wheat Germ GST
    Human GBP2-8632H Recombinant Human GBP2, His tagged Human Cell His
    Mouse Gbp2-1689M Recombinant Mouse Gbp2 protein, His & T7-tagged E.coli His/T7
    Mouse GBP2-6244M Recombinant Mouse GBP2 Protein Mammalian Cell His
    Rat Gbp2-1261R Recombinant Rat Gbp2 protein, His & T7-tagged E.coli His/T7

    GBP2 involved in several pathways and played different roles in them. We selected most pathways GBP2 participated on our site, such as Cytokine Signaling in Immune system, Immune System, Interferon Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with GBP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine Signaling in Immune system MARK3; CSF2RB; HBEGF; IL17RD; TRIM29; IFI27; TRIM31; IFIT12; TRIM26; IFIT11
    Immune System KIF5B; SIGIRR; CD300LH; ABI2; KIF3C; TRIM10; DHX9; OSBPL1A; RAP1GAP2B; KIF15
    Interferon Signaling IFITM2; IFIT12; TRIM3; TRIM29; IRF2; GBP1; TRIM68; EIF4G2; IFITM3; IRF9
    Interferon alpha/beta signaling IRF9; IFIT2; XAF1; GBP2; IRF6; IRF2; IFITM2; SAMHD1; IFI35; IFIT3
    Interferon gamma signaling TRIM6; IFI30; GBP4; TRIM2; TRIM45; TRIM10; IRF6; GBP1; GBP6; TRIM17

    GBP2 has several biochemical functions, for example, GTP binding, GTPase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GBP2 itself. We selected most functions GBP2 had, and list some proteins which have the same functions with GBP2. You can find most of the proteins on our site.

    Function Related Protein
    GTPase activity RAB1B; RAB31; RAB43; GTPBP5; RAB2A; RAB22A; RRAGD; GNB3; GNA12; DNM1A
    protein binding RPL15; SYCE2; TXLNA; Ntng2; SIGLEC5; BANF1; SNAI2; TMEM190; RPIA; HNRNPH3

    GBP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GBP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GBP2.

    q9wmx2-pro_0000037548; BNIP3L; ANXA7; SAT1; GADD45A; GSK3B; SEPHS1; SERPINB9; FXR1; BID; HSPE1; CSNK2B; PPP1R8; STK3; MAPK8IP2; PAFAH1B3; RPS6KA1; btuC3; q81k32_bacan

    James, SW; Banta, T; et al. Restraint of the G2/M Transition by the SR/RRM Family mRNA Shuttling Binding Protein SNXA(HRB1) in Aspergillus nidulans. GENETICS 198:617-U277(2014).
    Godoy, P; Cadenas, C; et al. Interferon-inducible guanylate binding protein (GBP2) is associated with better prognosis in breast cancer and indicates an efficient T cell response. BREAST CANCER 21:491-499(2014).

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