GCKR
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Official Full Name
glucokinase (hexokinase 4) regulator
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Overview
This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY). [provided by RefSeq, Jul 2008] -
Synonyms
GCKR; glucokinase (hexokinase 4) regulator; GKRP; FGQTL5; glucokinase regulatory protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Native Proteins
- Human
- Mouse
- Rat
- S.cerevisiae
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Mammalian Cell
- S.cerevisiae
- Yeast
- His
- His (Fc)
- Avi
- His|SUMO
- His|T7
- Myc
- DDK
- Myc|DDK
- N/A
- No tag
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | GCKR-660H | Recombinant Human GCKR Protein, MYC/DDK-tagged | HEK293 | Myc/DDK |
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| Human | GCKR-1223H | Recombinant Human GCKR Protein, His-SUMO-tagged | E.coli | His/SUMO |
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| Human | GCKR-6859H | Recombinant Human GCKR protein, His-tagged | E.coli | His | Gln91~Ala286 (Accession # Q14397) |
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| Human | GCKR-5984HCL | Recombinant Human GCKR 293 Cell Lysate | HEK293 | N/A |
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| Human | GCKR-1010H | Recombinant Human GCKR Protein (M1-Q625), His tagged | Insect Cell | His | M1-Q625 |
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| Human | GCKR-5760H | Recombinant Human GCKR protein, His-tagged | Yeast | His | 1-625aa |
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| Human | GCKR-6373H | Recombinant Human GCKR Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK |
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| Human | GCKR-1009H | Recombinant Human GCKR Protein (M1-Q625), Tag Free | Insect Cell | No tag | M1-Q625 |
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| Mouse | Gckr-6860M | Recombinant Mouse Gckr protein, His & T7-tagged | E.coli | His/T7 | Gly17~Lys261 (Accession # Q91X44) |
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| Mouse | Gckr-3174M | Recombinant Mouse Gckr Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
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| Rat | Gckr-6861R | Recombinant Rat Gckr protein, His-tagged | E.coli | His | Val90~Ala286 (Accession # Q07071) |
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| Rat | GCKR-2491R | Recombinant Rat GCKR Protein | Mammalian Cell | His |
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| Rat | GCKR-2147R-B | Recombinant Rat GCKR Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | GCKR-2147R | Recombinant Rat GCKR Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| S.cerevisiae | GCKR-8324S | Native S. cerevisiae GCKR | S.cerevisiae | N/A |
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- Involved Pathway
- Protein Function
- Interacting Protein
- GCKR Related Articles
GCKR involved in several pathways and played different roles in them. We selected most pathways GCKR participated on our site, such as Defective TRP may confer susceptibility towards thyroid papillary carcinoma (TPC), Disease, Disorders of transmembrane transporters, which may be useful for your reference. Also, other proteins which involved in the same pathway with GCKR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Defective TRP may confer susceptibility towards thyroid papillary carcinoma (TPC) | |
| Disease | CFTR;JAG1;OPN1SW;CHMP4B;TIRAP;GPC6;CYP11A1;PPIA;PPIAL4A |
| Disorders of transmembrane transporters | GCKR;CFTR |
| Glucose transport | GCKR;SLC2A3 |
| Hexose transport | SLC5A4;SLC2A3;SLC5A2;SLC5A9;GCKR |
| Metabolism | ARSE;OAZ2B;GLTPA;SPRB;COX18;APOF;SLC25A13;MED20;SLC46A1 |
| Metabolism of carbohydrates | SLC25A1A;DSEL;PYGMB;Gpc2;OXSR1;B3GAT2;ST3GAL3A;EPM2A;AGL |
| Regulation of Glucokinase by Glucokinase Regulatory Protein |
GCKR has several biochemical functions, for example, carbohydrate binding, fructose-6-phosphate binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GCKR itself. We selected most functions GCKR had, and list some proteins which have the same functions with GCKR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| carbohydrate binding | NCAN;CALR;NOMO3;Cd209g;PRPS2;CLEC2G;CD209;FREM1;CLEC4A |
| fructose-6-phosphate binding | PFKL;GCKR;PFKFB1 |
| protein binding | VEZT;NLRP12;SSX5;ASB7;RPP30;SHD;ARMC8;CXCR5;TUBGCP4 |
GCKR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GCKR here. Most of them are supplied by our site. Hope this information will be useful for your research of GCKR.
GCK; CDKN1A
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