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GCNT3

  • Official Full Name

    glucosaminyl (N-acetyl) transferase 3, mucin type

  • Overview

    This gene encodes a member of the N-acetylglucosaminyltransferase family. The encoded protein is a beta-6-N-acetylglucosamine-transferase that catalyzes the formation of core 2 and core 4 O-glycans on mucin-type glycoproteins.
  • Synonyms

    GCNT3; glucosaminyl (N-acetyl) transferase 3, mucin type; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3; C2/4GnT; C2GnT M; C2GnT2; hC2GnT-M; C2GnT-mucin type; beta1,6GlcNAc-transferase; beta1,6-N-acetylglucosaminyl;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GCNT3-13200H Recombinant Human GCNT3, His-tagged E.coli His 1-438a.a.
Human GCNT3-5978HCL Recombinant Human GCNT3 293 Cell Lysate HEK293 N/A
Human GCNT3-4807H Recombinant Human GCNT3 Protein, GST-tagged Wheat Germ GST
Human GCNT3-5188HF Recombinant Full Length Human GCNT3 Protein, GST-tagged In Vitro Cell Free System GST 438 amino acids
Mouse GCNT3-6272M Recombinant Mouse GCNT3 Protein Mammalian Cell His
Mouse GCNT3-3511M Recombinant Mouse GCNT3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse GCNT3-3511M-B Recombinant Mouse GCNT3 Protein Pre-coupled Magnetic Beads HEK293
Rat GCNT3-2495R Recombinant Rat GCNT3 Protein Mammalian Cell His
Rat GCNT3-2151R Recombinant Rat GCNT3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat GCNT3-2151R-B Recombinant Rat GCNT3 Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL15129HF Recombinant Full Length Human Beta-1,3-Galactosyl-O-Glycosyl-Glycoprotein Beta-1,6-N-Acetylglucosaminyltransferase 3(Gcnt3) Protein, His-Tagged E.coli expression system His Full Length (1-438)
Rhesus Macaque GCNT3-1823R Recombinant Rhesus monkey GCNT3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque GCNT3-1644R-B Recombinant Rhesus Macaque GCNT3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque GCNT3-1644R Recombinant Rhesus Macaque GCNT3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GCNT3 Related Articles

GCNT3 involved in several pathways and played different roles in them. We selected most pathways GCNT3 participated on our site, such as Metabolic pathways, Metabolism of proteins, Mucin type O-Glycan biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GCNT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Metabolic pathwaysUQCR11;ADSSL1;NDUFB2;COX5AA;PLCH1;ACSL1B;STT3B;CYP27B1;CYP3A7-CYP3AP1
Metabolism of proteinsTIMM44;KLHDC3;NSMCE4A;ADAMTS10;BCS1L;MPDU1A;ST6GALNAC1.2;LMAN2L;HYOU1
Mucin type O-Glycan biosynthesisPOC1B-GALNT4;C1GALT1;GALNTL4;GALNT6;B3GNT6;GALNT1;WBSCR17;GALNTL1;GALNT9
O-linked glycosylationADAMTSL1;ADAMTS5;ADAMTS3;ADAMTS10;MUC15;B3GNT6;SPON2;ST6GALNAC2;SPON1
O-linked glycosylation of mucinsGALNT13;GALNT6;GALNTL2;GALNT5;MUC5AC;MUC1;ST6GALNAC2;MUC13;GALNTL5
Post-translational protein modificationST6GALNAC2;PPP6C;NAPAB;MGAT4A;GNE;ARSE;ATPBD4;MAN1A2;ADAMTS3
mucin core 1 and core 2 O-glycosylationGALNTL2;GALNT6;GALNT13;GALNT5;GCNT3
terminal O-glycans residues modificationFUT9;GCNT3

GCNT3 has several biochemical functions, for example, N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity, acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity, beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GCNT3 itself. We selected most functions GCNT3 had, and list some proteins which have the same functions with GCNT3. You can find most of the proteins on our site.

Function Related Protein
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activityGCNT2;GCNT4;GCNT3
acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activityGCNT4A;GCNT4;GCNT3;GCNT1

GCNT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GCNT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GCNT3.

CASK; SNUPN; DHRSX; RBM18

Gonzalez-Vallinas, M; Vargas, T; et al. Clinical relevance of the differential expression of the glycosyltransferase gene GCNT3 in colon cancer. EUROPEAN JOURNAL OF CANCER 51:1-8(2015).
Petrosyan, A; Holzapfel, MS; et al. Restoration of Compact Golgi Morphology in Advanced Prostate Cancer Enhances Susceptibility to Galectin-1-Induced Apoptosis by Modifying Mucin O-Glycan Synthesis. MOLECULAR CANCER RESEARCH 12:1704-1716(2014).
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