GEMIN8
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Official Full Name
gem (nuclear organelle) associated protein 8
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Overview
The protein encoded by this gene is part of the SMN complex, which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus. The encoded protein binds to both SMN1 and the GEMIN6/GEMIN7 heterodimer, mediating their interaction. This protein is found in nuclear Gemini of Cajal bodies (gems) and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene. -
Synonyms
GEMIN8; gem (nuclear organelle) associated protein 8; FAM51A1, family with sequence similarity 51, member A1; gem-associated protein 8; FLJ20514; gemin-8; family with sequence similarity 51, member A1; FAM51A1; FLJ43072;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
GEMIN8 involved in several pathways and played different roles in them. We selected most pathways GEMIN8 participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with GEMIN8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA transport | FXR1;SRRM1;EIF3HA;POP7;EIF1;NMD3;NUP62;THOC7;EIF3EA |
GEMIN8 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GEMIN8 itself. We selected most functions GEMIN8 had, and list some proteins which have the same functions with GEMIN8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | AGTRAP;C14orf159;SPSB2;KLHL6;PYCARD;ATP6V0C;MED26;PRMT5;C15orf57 |
GEMIN8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GEMIN8 here. Most of them are supplied by our site. Hope this information will be useful for your research of GEMIN8.
LRRK2; Smn1; SMN1; Snrnp70; GEMIN5; GEMIN7
- Q&As
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