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GJC2

Official Full Name

gap junction protein, gamma 2, 47kDa
Overview

This gene encodes a gap junction protein. Gap junction proteins are members of a large family of homologous connexins and comprise 4 transmembrane, 2 extracellular, and 3 cytoplasmic domains. This gene plays a key role in central myelination and is involved in peripheral myelination in humans. Defects in this gene are the cause of autosomal recessive Pelizaeus-Merzbacher-like disease-1.
Synonyms

GJC2; gap junction protein, gamma 2, 47kDa; gap junction protein, alpha 12, 47kDa , GJA12; gap junction gamma-2 protein; connexin 47; CX46.6; CX47; SPG44; B230382L12Rik; Connexin 46.6; Connexin-46.6; Connexin-47; Connexin46.6; Connexin47; CX 46.6; Cx 47; CXG2_HUMAN; Gap junction alpha 12 protein; Gap junction alpha-12 protein; Gap junction gamma 2 protein; Gap junction protein alpha 12 47kDa; Gap junction protein gamma 2 47kDa; GAP JUNCTION PROTEIN, 47-KD; gap junction protein, gamma 12, 47kDa; GJA 12; GJA12; GJC 2; HLD 2; HLD2; MGC105119; MGC130506; OTTHUMP00000037763; PMLDAR; LMPH1C;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Bos taurus (Bovine)
Chicken
Homo sapiens (Human)
Mouse
Mus musculus (Mouse)
Rat
Rattus norvegicus (Rat)

Source

E.coli expression system
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Mouse	GJC2-6380M	Recombinant Mouse GJC2 Protein	Mammalian Cell	His		Inquiry
Mouse	GJC2-3577M	Recombinant Mouse GJC2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	GJC2-3577M-B	Recombinant Mouse GJC2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	GJC2-2556R	Recombinant Rat GJC2 Protein	Mammalian Cell	His		Inquiry
Rat	GJC2-2212R	Recombinant Rat GJC2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	GJC2-2212R-B	Recombinant Rat GJC2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Bos taurus (Bovine)	RFL28596BF	Recombinant Full Length Bovine Gap Junction Gamma-2 Protein(Gjc2) Protein, His-Tagged	E.coli expression system	His	Full Length (1-429)	Inquiry
Homo sapiens (Human)	RFL5312HF	Recombinant Full Length Human Gap Junction Gamma-2 Protein(Gjc2) Protein, His-Tagged	E.coli expression system	His	Full Length (1-439)	Inquiry
Mus musculus (Mouse)	RFL1604MF	Recombinant Full Length Mouse Gap Junction Gamma-2 Protein(Gjc2) Protein, His-Tagged	E.coli expression system	His	Full Length (1-440)	Inquiry
Rattus norvegicus (Rat)	RFL36576RF	Recombinant Full Length Rat Gap Junction Gamma-2 Protein(Gjc2) Protein, His-Tagged	E.coli expression system	His	Full Length (1-440)	Inquiry
Chicken	GJC2-4399C	Recombinant Chicken GJC2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
GJC2 Related Articles

GJC2 involved in several pathways and played different roles in them. We selected most pathways GJC2 participated on our site, such as Calcium Regulation in the Cardiac Cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with GJC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Calcium Regulation in the Cardiac Cell	CX30.3;KCNJ3;ADRa1A;GJA4;ADRB2;RGS5B;CX27.5;GJB6;CASQ1

GJC2 has several biochemical functions, for example, gap junction channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GJC2 itself. We selected most functions GJC2 had, and list some proteins which have the same functions with GJC2. You can find most of the proteins on our site.

Function	Related Protein
gap junction channel activity	GJA1;GJC2;CX43;GJB2;GJA8;CX30.3;PANX2;CX23;GJB3

GJC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GJC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GJC2.

Ybx3

Lyons, O; Sabine, A; et al. Failure of early organisation events underlies human venous valve failure caused by mutations in GJC2. BRITISH JOURNAL OF SURGERY 102:5-6(2015).

Abrams, CK; Scherer, SS; et al. A new mutation in GJC2 associated with subclinical leukodystrophy. JOURNAL OF NEUROLOGY 261:1929-1938(2014).