gli1
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  • Official Full Name
  • GLI family zinc finger 1
  • Background
  • GLI was first identified as a gene amplified in a malignant glioma capable of transforming primary cells in cooperation with adenovirus E1A. GLI belongs to the Kruppel family of zinc finger proteins that includes three mammalian GLI proteins: GLI1, GLI2
  • Synonyms
  • GLI1; GLI family zinc finger 1; GLI, glioma associated oncogene family zinc finger 1 , glioma associated oncogene homolog 1 (zinc finger protein); zinc finger protein GLI1; oncogene GLI; glioma-associated oncogene 1; glioma-associated oncogene homolog 1
Cat.#:GLI1-4954HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GLI1 Protein, GST-tagged
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Cat.#:GLI1-4955HTag:GST/pstS1
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GLI1 Protein, GST/pstS1-tagged
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Cat.#:GLI1-158HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GLI1 protein, GST-tagged
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Cat.#:GLI1-312HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human GLI1 protein, MYC/DDK-tagged
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Cat.#:GLI1-313HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GLI1 protein
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Cat.#:GLI1-6401MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GLI1 Protein
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Cat.#:Gli1-139RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Gli1 protein, His-tagged
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Cat.#:GLI1-9592ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GLI1
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Cat.#:GLI1-5905HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GLI1 293 Cell Lysate
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Involved Pathway

GLI1 involved in several pathways and played different roles in them. We selected most pathways GLI1 participated on our site, such as cAMP signaling pathway, Hedgehog signaling pathway, Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with GLI1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
cAMP signaling pathway
MAP2K2; LIPE; GRIN1; CALM4; RAP1A; PTGER3; HTR1E; PTGER2; AKT2; PLCE1
Hedgehog signaling pathway
PTCH2; DYRK1AA; GLI2A; BMP2B; BMP4; SMO; WNT2BB; GLI3; WNT16; WNT8A
Pathways in cancer
GNA11; FGF18; FGF1; TPM3; RASSF1; DAPK1; FGF5; MAPK9; PTGER1; TGFB3
Basal cell carcinoma
WNT1; FZD7; WNT6; APC2; FZD9; APC; WNT9A; FZD10; TCF7L2; WNT2B

Protein Function

GLI1 has several biochemical functions, for example, DNA binding, chromatin binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GLI1 itself. We selected most functions GLI1 had, and list some proteins which have the same functions with GLI1. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein OTPB; ZFP335; FOXA; TFPT; PURBA; ZFP191; ZNF614; GPBP1; MAFA; TAF9
Function chromatin binding
Related Protein FOS; CSNK2B; HMG20A; PDX1; JMJD5; SETD7; ATF2; ATF5; TCF7L2; RBPJL
Function metal ion binding
Related Protein NIM1; ICN; SMAD5; ZNF701; SNAI1; CSRP1A; CYGB2; CYP17A2; ATP8B5; PRDM1
Function microtubule binding
Related Protein MID2; KIF5C; JAKMIP1; KIF3A; KRIT1; KIF22; NDRG1; ARHGEF2; KIF1C; TUBGCP5
Function protein binding
Related Protein PPP1R11; ELMOD3; WEE1; TBC1D2; ERP44; BAG5; PTPN11A; UQCC2; CTAG1A; CWC22
Function sequence-specific DNA binding
Related Protein MIXL1; NFE2L2B; POU2F1; FOXD1L; LHX8A; ATF6B; DMRTA2; POU5F1; ARGFX; HOXC6A
Function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Related Protein SFPI1; SOX10; RFX1; CIR1; FOXC1; FOXF1; NFATC1; NR1H4; PTH; PURA
Function transcription regulatory region DNA binding
Related Protein KLF11; HOXA13; RREB1; ARID4A; TFE3; CDK5RAP2; MTERFD3; RFX3; PRDM5; NR5A2

Interacting Protein

GLI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GLI1.
SUFU

GLI1 Related Articles

De Luca, A; Parmigiani, E; et al. Exogenous Sonic Hedgehog Modulates the Pool of GABAergic Interneurons During Cerebellar Development. CEREBELLUM 14:72-85(2015).
Nakamura, T; Naruse, M; et al. Novel Hedgehog Agonists Promote Osteoblast Differentiation in Mesenchymal Stem Cells. JOURNAL OF CELLULAR PHYSIOLOGY 230:922-929(2015).