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GLS

  • Official Full Name

    Gls glutaminase

  • Overview

    This gene encodes the K-type mitochondrial glutaminase. The encoded protein is an phosphate-activated amidohydrolase;that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain;and kidney plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter;glutamate and maintaining acid-base balance in the kidney. Alternate splicing results in multiple transcript variants.
  • Synonyms

    GLS; glutaminase; AI314027; 6330442B14; B230365M23Rik;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GLS-2954H Recombinant Human GLS Protein (Ile221-Leu533), N-His tagged E.coli N-His Ile221-Leu533
Human GLS-1609H Recombinant Human GLS Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human GLS-1607H Recombinant Human GLS protein, His & T7-tagged E.coli His/T7 Ile221~Leu533 (Accession # O94925)
Human GLS-4979H Recombinant Human GLS Protein, GST-tagged Wheat Germ GST
Human GLS-6588H Recombinant Human GLS Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human GLS-1608H Recombinant Human GLS protein, His-tagged E.coli His
Human GLS-2970H Recombinant Human GLS protein, GST-tagged E.coli GST 370-669aa
Human GLS-2971H Recombinant Human GLS protein, GST-tagged E.coli GST 616-669aa
Human GLS-08H Active Recombinant Human GLS Protein, His-tagged E.coli His
Human GLS-990H-B Recombinant Human GLS Protein Pre-coupled Magnetic Beads HEK293
Human GLS-270HFL Recombinant Full Length Human GLS Protein, C-Flag-tagged Mammalian cells Flag
Human GLS-990H Recombinant Human GLS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse GLS-6426M Recombinant Mouse GLS Protein Mammalian Cell His
Mouse GLS-3605M Recombinant Mouse GLS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse GLS-3605M-B Recombinant Mouse GLS Protein Pre-coupled Magnetic Beads HEK293
Mouse Gls-1608M Recombinant Mouse Gls protein, His & T7-tagged E.coli His/T7 Leu31~Asp253 (Accession # D3Z7P3)
Mouse Gls-3231M Recombinant Mouse Gls Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat GLS-2573R Recombinant Rat GLS Protein Mammalian Cell His
Rat GLS-2228R Recombinant Rat GLS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat GLS-2228R-B Recombinant Rat GLS Protein Pre-coupled Magnetic Beads HEK293
Chicken GLS-2907C Recombinant Chicken GLS Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GLS Related Articles

GLS involved in several pathways and played different roles in them. We selected most pathways GLS participated on our site, such as Arginine biosynthesis, Alanine, aspartate and glutamate metabolism, D-Glutamine and D-glutamate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GLS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Arginine biosynthesisGLULA;NOS2A;GPT;GPT2L;ASL;GOT2;GLS;GLUD1B;GLUD1
Alanine, aspartate and glutamate metabolismGOT2B;NIT2;GOT1;GAD1B;AGXT2;ALDH5A1;GOT2A;ASPA;GLULC
D-Glutamine and D-glutamate metabolismGLSA;GLS2;GLUD1A;GLUD1;GLUD1B;GLS;ybaS;GLUD2
Metabolic pathwaysDNMT3;NNMT;IDUA;SDHD;GLB1;FUT9;SPTLC2B;CBR1L;CYP21A1
Glutamatergic synapseGNG4;GNB1;PRKCA;ADRBK2;GRM3;GNG12;GRM5;GNG11;GRIN3B
GABAergic synapseGABRG2;GABRR1;GABBR1;GNG10;SRC;GABRB3;GABARAP;GABRA3;GABRG1
Proximal tubule bicarbonate reclamationAQP1;ATP1B1;ATP1A3;FXYD2;SLC4A4;MDH1;CA2;GLS;Car2
MicroRNAs in cancerUBE2I;DNMT1;TPM1;SHC1;WNT3A;MAP2K1;ITGB3;DNMT3A;FOXP1
Central carbon metabolism in cancerKRAS;PIK3R1;SLC1A5;NTRK1;HRAS;PKM;MAPK3;PIK3R5;PFKM

GLS has several biochemical functions, for example, glutaminase activity, hydrolase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GLS itself. We selected most functions GLS had, and list some proteins which have the same functions with GLS. You can find most of the proteins on our site.

Function Related Protein
glutaminase activityGLS2;GLS;GLSA;NADSYN1
hydrolase activityCAPN5A;ATP1A1B;EHD2;DPEP3;CHD1L;AADACL4;C9orf156;PPP1CBL;FAHD2A
protein bindingDSTN;FOXB1;TTF2;AGPAT1;BCL7A;SUMO1;NDUFS7;LHX9;PFDN4

GLS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLS here. Most of them are supplied by our site. Hope this information will be useful for your research of GLS.

Abcf1

Taplin, CE; Mojibian, M; et al. Antibodies to the Wheat Storage Globulin Glo-3A in Children Before and at Diagnosis of Celiac Disease. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION 52:21-25(2011).
Simpson, M; Mojibian, M; et al. An exploration of Glo-3A antibody levels in children at increased risk for type 1 diabetes mellitus. PEDIATRIC DIABETES 10:563-572(2009).
  • Q&As
  • Reviews

Q&As (7)

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What is the main function of GLS in cellular metabolism? 02/14/2022

GLS catalyzes the conversion of glutamine to glutamate, playing a crucial role in amino acid metabolism.

What role does GLS play in neurotransmitter production? 10/19/2021

GLS is vital for neurotransmitter production, influencing glutamate and GABA levels.

How does GLS contribute to glutaminolysis? 09/04/2021

It facilitates glutaminolysis, enabling cells to utilize glutamine for energy and biosynthesis.

How is GLS activity implicated in cancer cell proliferation? 03/03/2021

In cancer, upregulated GLS supports rapid proliferation by fueling energy and biosynthetic pathways.

Are there therapeutic strategies targeting GLS in disease treatment? 02/27/2021

Therapeutic strategies targeting GLS aim to inhibit its activity, especially in glutamine-dependent cancers.

What is the relationship between GLS activity and cellular energy production? 06/20/2020

GLS activity contributes to cellular ATP production by providing intermediates for the TCA cycle.

In which tissues is GLS highly expressed? 03/30/2020

GLS is highly expressed in tissues with rapid cell division and high metabolic rates, such as cancer cells.

Customer Reviews (3)

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Reviews
11/23/2022

    Highly recommend for experiments.

    08/20/2021

      Worked well, good quality.

      05/29/2021

        Satisfied with product performance.

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