GLS
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Official Full Name
Gls glutaminase
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Overview
This gene encodes the K-type mitochondrial glutaminase. The encoded protein is an phosphate-activated amidohydrolase;that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain;and kidney plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter;glutamate and maintaining acid-base balance in the kidney. Alternate splicing results in multiple transcript variants. -
Synonyms
GLS; glutaminase; AI314027; 6330442B14; B230365M23Rik;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- Myc|DDK
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- GLS Related Articles
GLS involved in several pathways and played different roles in them. We selected most pathways GLS participated on our site, such as Arginine biosynthesis, Alanine, aspartate and glutamate metabolism, D-Glutamine and D-glutamate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GLS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Arginine biosynthesis | GLULA;NOS2A;GPT;GPT2L;ASL;GOT2;GLS;GLUD1B;GLUD1 |
Alanine, aspartate and glutamate metabolism | GOT2B;NIT2;GOT1;GAD1B;AGXT2;ALDH5A1;GOT2A;ASPA;GLULC |
D-Glutamine and D-glutamate metabolism | GLSA;GLS2;GLUD1A;GLUD1;GLUD1B;GLS;ybaS;GLUD2 |
Metabolic pathways | DNMT3;NNMT;IDUA;SDHD;GLB1;FUT9;SPTLC2B;CBR1L;CYP21A1 |
Glutamatergic synapse | GNG4;GNB1;PRKCA;ADRBK2;GRM3;GNG12;GRM5;GNG11;GRIN3B |
GABAergic synapse | GABRG2;GABRR1;GABBR1;GNG10;SRC;GABRB3;GABARAP;GABRA3;GABRG1 |
Proximal tubule bicarbonate reclamation | AQP1;ATP1B1;ATP1A3;FXYD2;SLC4A4;MDH1;CA2;GLS;Car2 |
MicroRNAs in cancer | UBE2I;DNMT1;TPM1;SHC1;WNT3A;MAP2K1;ITGB3;DNMT3A;FOXP1 |
Central carbon metabolism in cancer | KRAS;PIK3R1;SLC1A5;NTRK1;HRAS;PKM;MAPK3;PIK3R5;PFKM |
GLS has several biochemical functions, for example, glutaminase activity, hydrolase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GLS itself. We selected most functions GLS had, and list some proteins which have the same functions with GLS. You can find most of the proteins on our site.
Function | Related Protein |
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glutaminase activity | GLS2;GLS;GLSA;NADSYN1 |
hydrolase activity | CAPN5A;ATP1A1B;EHD2;DPEP3;CHD1L;AADACL4;C9orf156;PPP1CBL;FAHD2A |
protein binding | DSTN;FOXB1;TTF2;AGPAT1;BCL7A;SUMO1;NDUFS7;LHX9;PFDN4 |
GLS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLS here. Most of them are supplied by our site. Hope this information will be useful for your research of GLS.
Abcf1
- Q&As
- Reviews
Q&As (7)
Ask a questionGLS catalyzes the conversion of glutamine to glutamate, playing a crucial role in amino acid metabolism.
GLS is vital for neurotransmitter production, influencing glutamate and GABA levels.
It facilitates glutaminolysis, enabling cells to utilize glutamine for energy and biosynthesis.
In cancer, upregulated GLS supports rapid proliferation by fueling energy and biosynthetic pathways.
Therapeutic strategies targeting GLS aim to inhibit its activity, especially in glutamine-dependent cancers.
GLS activity contributes to cellular ATP production by providing intermediates for the TCA cycle.
GLS is highly expressed in tissues with rapid cell division and high metabolic rates, such as cancer cells.
Customer Reviews (3)
Write a reviewHighly recommend for experiments.
Worked well, good quality.
Satisfied with product performance.
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