GNAI2
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Official Full Name
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
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Overview
Guanine nucleotide-binding protein G(i), alpha-2 subunit is a protein that in humans is encoded by the GNAI2 gene. -
Synonyms
Giα-2-Subunit; GNAI2; Guanine nucleotide-binding protein G(i), alpha-2 subunit; Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2; GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1; guanine nucleotide-binding protein G(i) subunit alpha-2; OTTHUMP00000211065; OTTHUMP00000211066; OTTHUMP00000211067; OTTHUMP00000211070; adenylate cyclase-inhibiting G alpha protein; GTP-binding regulatory protein Gi alpha-2 chain;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- Flag|His
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
GNAI2 involved in several pathways and played different roles in them. We selected most pathways GNAI2 participated on our site, such as Rap signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNAI2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Rap signaling pathway | FGF10;P2RY1;AKT1;PDGFRB;MET;SIPA1L2;GRIN1;VEGFC;PIK3CD |
| cGMP-PKG signaling pathway | IRS1;LOC100328615;CALM1;GNAI3;GUCY1A3;GNAI2;VDAC2;PDE3A;ATP2B1 |
| cAMP signaling pathway | GRIA1;RAC2;HTR1E;MAPK3;DRD1A;CREB5;EP300;CNGA2;ATP2B1 |
| Chemokine signaling pathway | SHC3;CCR1L1;GNAI1;FGR;RELA;CCR6;RAP1B;CCL14;RHOA |
| Sphingolipid signaling pathway | MAPK3;PPP2CB;MAPK13;PRKCZ;SPTLC2;PRKCB;PLCB3;PIK3R1;PPP2R2D |
| Adrenergic signaling in cardiomyocytes | PPP2R2C;ADRA1B;CREB3L4;CACNB3;CALM1A;SLC14A2;CREM;ADRA1D;ATP2B1A |
| Axon guidance | ADAM10;RHOA;SEMA6C;COL4A5;NADL1.1;NRG3;SEMA3A;KALRNB;EZRA |
| Tight junction | MPP5A;AKT2L;ACTB2;CLDNK;YBX3;CDC42;CLDN15LB;CRB3A;CTTN |
| Gap junction | TUBA8L4;NRAS;TUBB5;TUBA8L2;TUBA3A;ADCY1B;TUBAL3;TUBA1A;SOS1 |
| Platelet activation | LYN;ITGB1;PPP1CA;MYLK;MYL12B;PPP1R12A;ACTG1;MAPK12;F2RL3 |
| Leukocyte transendothelial migration | ITGAM;CLDN16;ACTN3;MAPK13;NCF2;CLDN22;CLDN9;MYL5;MYL9 |
| Circadian entrainment | PRKG2;FOS;AKR1C1;GNG12;PER1;NOS1;RASD1;CAMK2B;CACNA1H |
| Retrograde endocannabinoid signaling | MAPK9;ITPR1;PRKCA;MAPK1;GABRA2;GNB4;GNAI3;GABRA5;GNG4 |
| Glutamatergic synapse | PPP3CC;PRKACB;PRKCG;GNG5;SLC17A6;GNAI3;GRM2;GRM3;PLCB4 |
| Cholinergic synapse | PIK3R1;KCNJ3;ITPR3;GNGT1;KCNJ12;GNG12;GNGT2;KCNJ2;NRAS |
| Serotonergic synapse | ARAF;CYP2C55;GNG4;HTR4;CYP2C37;HTR2C;GNB4;GNG10;GABRB3 |
| GABAergic synapse | GNAI3;GNAI2;NSF;GNG2;PRKACG;GAD1;PRKACA;GNB3;SRC |
| Dopaminergic synapse | GNAI3;GRIA4;PRKACB;DRD3;PRKCA;PPP1CA;PPP2R5B;PPP2R5C;CAMK2A |
| Long-term depression | GRID2;GNAQ;PRKCG;RYR1;HRAS;PPP2R1B;CRH;GNA11;LYN |
| Progesterone-mediated oocyte maturation | INSB;RPS6KAL;CCNB2;MAPK8;AKT3A;MAPK1;MAPK12B;MAPK3;ANAPC7 |
| Estrogen signaling pathway | PRKACB;CALM4;PRKACG;HSP90B1;CREB3L3;FOS;PIK3CD;ESR1;GABBR1 |
| Melanogenesis | WNT11R;DVL1B;WNT7AA;WNT4;MAP2K2B;KITB;RAF1A;GNAIA;TYR |
| Oxytocin signaling pathway | MYLK3;GNAI1;MAP2K5;CACNA2D4;PLA2G4F;RYR1;MYL9;PLCB3;ROCK1 |
| Regulation of lipolysis in adipocytes | TSHR;PIK3R5;AQP7;GNAI3;PRKACB;PIK3R3;GNAI1;Adcy4;PRKG1 |
| Renin secretion | CALM4;REN;PLCB2;GNAI3;CLCA5;PTGER2;ITPR3;GUCY1A3;LOC100328615 |
| Gastric acid secretion | CALM2;PRKCG;ATP1B1;CALM3;ACTB;MYLK3;GNAI3;Car2;SST |
| Parkinsons disease | NDUFA13;NDUFC2-KCTD14;DRD1A;VDAC3;NDUFS5;GPR37;SLC25A6;MT-ATP6;UQCRH |
| Cocaine addiction | FOSB;CDK5R1;SLC18A2;SLC6A3;CREB3L1;CREB3L3;PRKACG;RELA;RGS9 |
| Alcoholism | MAP2K1;CALM4;SHC4;H3F3C;HRAS;HIST1H2BI;HIST1H2BH;GM14479;HIST1H4M |
| Pertussis | LY96;CALM4;MAPK3;IRF3;ITGB1;GNAI1;CXCL6;IL12B;MAPK10 |
| Chagas disease (American trypanosomiasis) | PIK3CD;TICAM1;Ccl12;TLR4;MAPK3;CALR;SERPINE1;ACE;CD3E |
| Toxoplasmosis | HSPA1L;TYK2;BCL2;GNAI1;TGFB1;MAP2K6;HSPA2;HLA-DRB4;HSPA8 |
| Pathways in cancer | MMP1A;FZD5;PLCG1;STK36;FGF12;PIK3CG;FGFR3;FGF13;AKT2 |
GNAI2 has several biochemical functions, for example, G-protein beta/gamma-subunit complex binding, G-protein coupled receptor binding, GTP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GNAI2 itself. We selected most functions GNAI2 had, and list some proteins which have the same functions with GNAI2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein beta/gamma-subunit complex binding | GNAL;GNA11B;GNA14;GNAT3;GNAO1;GNAT1;GNAI2;CETN4;GNAO1B |
| G-protein coupled receptor binding | ARRB2;HSPA1B;GNA13A;FCN1;PROK2;GNAT3;PSAP;PACRG;GNA12A |
| GTP binding | EIF2B1;ADSSL;GTPBP5;DNM1A;RALAA;SAR1AB;RHOQ;RERGLA;RAB14 |
| GTPase activity | RRAGCA;RAB11AL;GTPBP3;RHOT1;TUBA7L;RRAGA;EFTUD1;RHOD;IRGF1 |
| metal ion binding | PRKCI;STAMBP;TNNC1;MICALL2B;PRKCBP1L;NRXN1B;NUDT11;ZNF664;NT5C2L1 |
| protein binding | EXOSC8;CFH;IFRD2;SHC1;SOX10;PRICKLE1;TAF1A;GNA13;TOPORS |
| signal transducer activity | CC2D1A;TMED4;OLFR688;VMN1R46;GPR31B;OLFCG1;STAT3;GAB1;TAS2R117 |
GNAI2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNAI2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GNAI2.
CXCR5; MDFI; NCF2; RGS20; HSP90AB1
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