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GNAO1

  • Official Full Name

    guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O

  • Overview

    Gi alpha subunit (or Gi/G0 or Gi protein) is a heterotrimeric G protein subunit that inhibits the production of cAMP from ATP.
  • Synonyms

    Goα-Subunit; Gnao1; guanine nucleotide binding protein, alpha O; Gnao; alphaO; Galphao; AW050213; Guanine nucleotide binding protein G(o) subunit alpha; Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; DKFZp686O0962; G-ALPHA-o; G alpha o; G protein alpha 0; GNAO 1; Go alpha; Guanine nucleotide binding protein (G pro-tein) alpha activating activity polypeptide O; Guanine nucleotide binding protein alpha activating polypeptide; OT-THUMP00000164318; OTTHUMP00000164319;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GNAO1-28088TH Recombinant Human GNAO1, His-tagged E.coli His
Human GNAO1-13349H Recombinant Human GNAO1, GST-tagged E.coli GST 1-302a.a.
Human GNAO1-5868HCL Recombinant Human GNAO1 293 Cell Lysate HEK293 N/A
Human GNAO1-5326HF Recombinant Full Length Human GNAO1 Protein, GST-tagged In Vitro Cell Free System GST 354 amino acids
Human GNAO1-997H Recombinant Human GNAO1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human GNAO1-5045H Recombinant Human GNAO1 Protein, GST-tagged Wheat Germ GST
Human GNAO1-1523HFL Recombinant Full Length Human GNAO1 Protein, C-Flag-tagged Mammalian cells Flag
Human GNAO1-2208H Recombinant Human GNAO1 Protein, His-tagged E.coli N-His Gly2-Tyr354
Human GNAO1-997H-B Recombinant Human GNAO1 Protein Pre-coupled Magnetic Beads HEK293
Mouse GNAO1-7018M Recombinant Mouse GNAO1 Protein Mammalian Cell His
Mouse Gnao1-2975M Recombinant Mouse Gnao1 protein, His-tagged E.coli His 2-354aa
Mouse GNAO1-3760M Recombinant Mouse GNAO1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse GNAO1-3760M-B Recombinant Mouse GNAO1 Protein Pre-coupled Magnetic Beads HEK293
Mouse GNAO1-1400M Recombinant Mouse GNAO1 Protein (2-354 aa), His-tagged Yeast His 2-354 aa
Mouse Gnao1-5417M Recombinant Mouse Gnao1 protein Yeast N/A 2-354aa
Mouse Gnao1-3257M Recombinant Mouse Gnao1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat GNAO1-2596R Recombinant Rat GNAO1 Protein Mammalian Cell His
Rat GNAO1-2251R Recombinant Rat GNAO1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat GNAO1-2251R-B Recombinant Rat GNAO1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque GNAO1-1893R Recombinant Rhesus monkey GNAO1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque GNAO1-1713R-B Recombinant Rhesus Macaque GNAO1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque GNAO1-1713R Recombinant Rhesus Macaque GNAO1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken GNAO1-4936C Recombinant Chicken GNAO1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GNAO1 Related Articles

GNAO1 involved in several pathways and played different roles in them. We selected most pathways GNAO1 participated on our site, such as Rap signaling pathway, Circadian entrainment, Retrograde endocannabinoid signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNAO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Rap signaling pathwayFGF9;ITGB1;FGF6;VEGFB;FGF13;APBB1IP;SIPA1L1;INS;CALM3
Circadian entrainmentCAMK2A;PER2;GNAQ;GNB1;GRIN2D;CALM3;RYR1;CALML3;GNG5
Retrograde endocannabinoid signalingGNGT2;MAPK9;GNAQ;GABRD;GABRR2;PLCB1;NAPEPLD;MAPK12;Adcy4
Glutamatergic synapseGNB4;GRM8;SHANK2;SLC38A2;MAPK3;GNG3;SLC1A2;SLC1A6;PLCB3
Cholinergic synapseCAMK2G;GNB4;CHRM1;AKT1;KCNQ3;Adcy4;CREB3L1;CREB3;CHAT
Serotonergic synapseALOX15B;HTR3B;GNGT1;GNB1;CYP2C39;GABRB3;PLA2G4D;HTR1B;MAPK3
GABAergic synapseGABRB1;GNAI2;GABARAPL2;GABRR1;GNG12;GAD2;PRKCA;GNG13;SLC38A5
Dopaminergic synapseCREB3;CLOCK;GNAS;GNB1;PRKCG;PPP2R5A;PPP2R1B;PLCB1;ITPR3
Long-term depressionRAF1;PRKG1;PRKCB;PRKG2;GNAI2;HRAS;PPP2CB;LYN;PRKCA
Estrogen signaling pathwayNRAS;CREB3L3;Adcy4;SP1;ATF4;SHC2;HSPA1L;HSPA1A;PIK3CG
MelanogenesisMAP2K2B;CALM1B;WNT8A;Adcy4;MITFA;FZD9B;TYRP1B;PRKACA;FZD8A
Oxytocin signaling pathwayCALML3;PPP3R1;PIK3CA;PPP3R2;CCND1;KRAS;CAMK4;PPP1R12A;GNAO1
AlcoholismHIST1H2AI;HDAC4;SHC1;GRB2;MAPK3;SHC3;RAF1;HIST2H4;GNG3
Chagas disease (American trypanosomiasis)MYD88;IFNGR1;PPP2R2B;PIK3CA;PLCB4;CD3E; CD3D;IRAK4;CASP8;ACE
ToxoplasmosisIFNGR2;HLA-DMB;PIK3CB;NOS2;HLA-DMA;IL10RA;MAPK9;HSPA1L;Toxoplasma Gondii Major Surface Antigen P30

GNAO1 has several biochemical functions, for example, G-protein beta/gamma-subunit complex binding, G-protein coupled serotonin receptor binding, GTP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GNAO1 itself. We selected most functions GNAO1 had, and list some proteins which have the same functions with GNAO1. You can find most of the proteins on our site.

Function Related Protein
G-protein beta/gamma-subunit complex bindingGNAO1;GNAL;GNAI1;GNAT2;ADORA1;GNA11B;GNAO1B;GNAQ;GNAV1
G-protein coupled serotonin receptor bindingGNAI3;GNAO1;GNAO1B;GNAO1A;GNAI1;GNAZ;GNAIA
GTP bindingRHOT1;URGCP;RAB4B;RAB3DB;ARF3B;GNA14;RHOUA;GBP4;GNA12
GTPase activating protein bindingTUBB;PIN1;FMNL1;PTBP3;GNAI3;MEX3B;GNAO1;RGS14;TSC1
GTPase activityRAB18A;RAB5AB;RAB33A;GBP4;RAP1A;TUBB1;RAB1BA;RAB5C;TUBB4B
corticotropin-releasing hormone receptor 1 bindingCRH;GNAO1A;GNAS;UCN;GNAO1;GNAO1B
metal ion bindingZFC3H1;RNF17;ADHFE1;ZFP524;TRMT1;RXRGB;LOC780933;FBXO40.1;SP6
mu-type opioid receptor bindingGNAS;GNAO1B;WLS;FLNA;GNAO1;GNAO1A;GPR177
signal transducer activitySTAT2;OLFR510;TAAR6;CXCR3.1;MUL1;TAAR10C;TAS2R123;PLCB3;OLFCQ19

GNAO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNAO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GNAO1.

gtp; APP; CXCR5; Haus4; DCTN2; 15-deoxy-delta(12,14; HTT

Zupancic, K; Blejec, A; et al. Identification of plasma biomarker candidates in glioblastoma using an antibody-array-based proteomic approach. RADIOLOGY AND ONCOLOGY 48:257-266(2014).
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