gnao1
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  • Official Full Name
  • guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
  • Background
  • Gi alpha subunit (or Gi/G0 or Gi protein) is a heterotrimeric G protein subunit that inhibits the production of cAMP from ATP.
  • Synonyms
  • Go╬▒-Subunit; Gnao1; guanine nucleotide binding protein, alpha O; Gnao; alphaO; Galphao; AW050213; Guanine nucleotide binding protein G(o) subunit alpha; Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; DKFZp686O0962; G-ALPHA-o; G alpha o; G protein alpha 0; GNAO 1; Go alpha; Guanine nucleotide binding protein (G pro-tein) alpha activating activity polypeptide O; Guanine nucleotide binding protein alpha activating polypeptide; OT-THUMP00000164318; OTTHUMP00000164319
Cat.#:GNAO1-1400MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse GNAO1 Protein (2-354 aa), His-tagged
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Cat.#:GNAO1-5045HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GNAO1 Protein, GST-tagged
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Cat.#:GNAO1-13349HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GNAO1, GST-tagged
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Cat.#:GNAO1-28088THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GNAO1, His-tagged
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Cat.#:GNAO1-7018MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GNAO1 Protein
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Cat.#:GNAO1-2596RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GNAO1 Protein
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Cat.#:GNAO1-1893RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey GNAO1 Protein, His-tagged
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Cat.#:GNAO1-4936CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GNAO1
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Cat.#:GNAO1-5868HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GNAO1 293 Cell Lysate
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Involved Pathway

GNAO1 involved in several pathways and played different roles in them. We selected most pathways GNAO1 participated on our site, such as Rap signaling pathway, Circadian entrainment, Retrograde endocannabinoid signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNAO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Rap signaling pathway
RALGDS; PIK3R1; MAPK3; PLCB1; GNAQ; ANGPT1; HRAS; VAV2; Fgf15; PLCG1
Circadian entrainment
GNGT2; FOS; CALML5; CACNA1G; PRKACG; KCNJ9; GNAO1; GNG4; PRKACA; KCNJ5
Retrograde endocannabinoid signaling
ITPR3; GRIA1; PLCB2; GNG5; SLC17A8; GNB4; SLC17A7; PRKCA; GRIA3; GABRB1
Glutamatergic synapse
PPP3CB; GLS2; GRM7; SLC1A1; GNAS; PLD2; GRIN1; SLC17A7; GRIN2C; GLS
Cholinergic synapse
KCNJ4; PIK3CG; GNG5; KCNQ3; ITPR3; SLC5A7; GNGT2; GNB1; CHRNA6; JAK2
Serotonergic synapse
CYP2C39; KCND2; ITPR3; MAPK3; HTR1F; Casp3; GNG8; CYP2C50; HTR4; GABRB3
GABAergic synapse
GABBR1; GABRA5; PLCL1; GLS2; GABRA6; GPHN; PRKCA; GABRG2; GNG12; SLC38A2
Dopaminergic synapse
KCNJ6; PLCB4; ITPR1; CAMK2B; GNG2; PPP3CC; PPP1CA; GNB2; KCNJ5; KCNJ3
Long-term depression
RYR1; PRKCG; LYN; HRAS; GRID2; PLA2G4F; ITPR3; GRM1; PPP2CB; ITPR1
Estrogen signaling pathway
CREB3L3; PLCB3; HSPA2; GABBR2; CALM2; NOS3; GRM1; CALML5; CREB5; PIK3CG
Melanogenesis
CAMK2D1; WNT7AA; Fzd4; WNT1; MAP2K2; FZD10; TCF7L1A; GNA15.4; FZD7; MITFB
Oxytocin signaling pathway
PPP1R12A; KRAS; CACNG7; CAMK1; CAMK2G; Adcy4; PPP1CC; PIK3CD; CACNA2D3; PLCB1
Morphine addiction
GABBR1; PDE4C; GNG10; GNG12; GNG8; GABRA4; GABRP; PDE2A; LOC100328615; Adcy4
Alcoholism
HIST1H2BA; HIST1H2BP; SLC18A2; HIST1H2BL; CREB3L4; PPP1CC; CAMKK2; HIST1H2AM; H3F3C; CREB5
Chagas disease (American trypanosomiasis)
IL1B; SMAD3; CASP8; GNAO1; PIK3CG; TGFBR1; MAPK10; CD3G; TRAF6; GNAI3
Toxoplasmosis
TNF; SOCS1; CYCS; HLA-DRA; ITGB1; AKT1; BIRC3; HLA-DRB3; TNFRSF1A; GNAO1

Protein Function

GNAO1 has several biochemical functions, for example, G-protein beta/gamma-subunit complex binding, G-protein coupled serotonin receptor binding, GTP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GNAO1 itself. We selected most functions GNAO1 had, and list some proteins which have the same functions with GNAO1. You can find most of the proteins on our site.
Function
Related Protein
Function G-protein beta/gamma-subunit complex binding
Related Protein GNAZ; GNA15; GNAI2; GNA12A; GNA13A; GNA12; GNA15.1; CETN2; GNAQ; GNAI1
Function G-protein coupled serotonin receptor binding
Related Protein GNAO1B; GNAI1; GNAZ; GNAO1; GNAIA; GNAI3; GNAO1A
Function GTP binding
Related Protein GNAI2B; RAB32; RAP1AB; SAR1A; TUBB2B; ARF3B; GIMAP8; TUBA8L; GNA12A; GNA15.1
Function GTPase activating protein binding
Related Protein CDH1; GNAI1; GAPVD1; MEX3B; PLCD1; RGS14; TSC1; FMNL1; TUBB; GNAO1
Function GTPase activity
Related Protein MSTO1; RABL2B; RAB41; RALAB; EEF1A1A; CDC42; GFM2; RAB8B; RAB39BA; TUBB4A
Function corticotropin-releasing hormone receptor 1 binding
Related Protein GNAO1; GNAO1A; CRH; GNAO1B; GNAS; UCN
Function metal ion binding
Related Protein ITGB1; STS; BCL6AB; PPM1LB; KLF17; ZFP775; ZFP82; NEK1; CYP2AA7; ZBTB41
Function mu-type opioid receptor binding
Related Protein GNAO1B; GNAO1; GNAS; GPR177; WLS; GNAO1A; FLNA
Function signal transducer activity
Related Protein TACR1A; BST2; DRD7; SLC35B2; ACKR3B; PROKR1A; VMN1R50; AIP; TAAR12C; TAAR7F

Interacting Protein

GNAO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNAO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GNAO1.
gtp; APP; CXCR5; Haus4; DCTN2; 15-deoxy-delta(12,14; HTT

GNAO1 Related Articles

Zupancic, K; Blejec, A; et al. Identification of plasma biomarker candidates in glioblastoma using an antibody-array-based proteomic approach. RADIOLOGY AND ONCOLOGY 48:257-266(2014).