GNAQ
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Official Full Name
guanine nucleotide binding protein (G protein), q polypeptide
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Overview
This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2.[provided by RefSeq, Nov 2010] -
Synonyms
GNAQ; guanine nucleotide binding protein (G protein), q polypeptide; GAQ; SWS; CMC1; G-ALPHA-q; guanine nucleotide-binding protein G(q) subunit alpha; guanine nucleotide-binding protein alpha-q;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E. coli
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|Myc
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
GNAQ involved in several pathways and played different roles in them. We selected most pathways GNAQ participated on our site, such as Rap signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNAQ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Rap signaling pathway | KRAS;ITGA2B;PDGFD;PRKCA;HGF;PRKD2;PLCE1;FGF12;MET |
| Calcium signaling pathway | OXTR;ADRA1BB;DRD1B;PTGER1C;CACNA1D;P2RX1;EDNRAA;STIM2;CALM |
| cGMP-PKG signaling pathway | PPP1CC;PDE3B;PIK3CA;ATP1B4;AKT2;PDE3A;ATF4;KCNJ8;PLCB4 |
| Sphingolipid signaling pathway | GNAQ;BID;PIK3CG;PPP2R1B;SPTLC1;MAPK1;PLD1;SGMS1;BDKRB2 |
| Adrenergic signaling in cardiomyocytes | CAMK2G1;CACNA1SB;ATP1B4;GNAS;CALM3;ATF6B;CACNB3;VMHC;PRKACBB |
| Vascular smooth muscle contraction | PPP1CC;MYLK3;Adcy4;MAP2K2B;GNA15.4;PLA2G6;CACNA1SB;CALCRLA;PLA2G12A |
| Gap junction | PRKACAA;GUCY1A3;PRKCB;DRD2B;GNAI2A;SRC;PRKG1;MAPK3;TUBB6 |
| Platelet activation | ACTG1;COL27A1;ITGA2;SYK;PPP1CC;PLCG2;P2RX1;PLA2G4A;PPP1CB |
| Circadian entrainment | GRIN2C;GNG12;GNGT2;CALM1;MTNR1B;PRKACG;GNAO1;MTNR1A;GNGT1 |
| Long-term potentiation | PLCB1;CAMK2B;PPP3CB;MAP2K2;PPP1CB;RPS6KA2;GNAQ;GRIN1;RPS6KA1 |
| Retrograde endocannabinoid signaling | DAGLB;SLC17A8;GNG13;GABRA1;PRKCA;PRKACB;PRKCG;SLC17A7;GABRA2 |
| Glutamatergic synapse | GRM6;GRIK4;PPP3R2;SLC38A1;SHANK3;GLS2;DLGAP1;GNB3;PLA2G4A |
| Cholinergic synapse | KCNQ3;PRKACA;GNG12;GNB1;PIK3R1;ATF4;BCL2;CREB3L2;CAMK2B |
| Serotonergic synapse | CYP2J5;CYP2D9;HTR2A;GNAQ;GNGT2;CYP2C38;GNG11;MAOA;HTR2B |
| Dopaminergic synapse | ATF6B;ATF4;PPP2R1B;GRIA2;GNG13;PPP2R5E;GRIN2B;MAPK13;KCNJ6 |
| Long-term depression | HRAS;GRIA1;PLCB4;PLA2G4F;KRAS;PLCB2;NRAS;PRKCB;PLA2G4D |
| Inflammatory mediator regulation of TRP channels | PLA2G4C;HTR2A;PRKACA;MAPK8;CAMK2G;PRKCA;CYP2C39;IL1RAP;ALOX12 |
| Insulin secretion | SNAP25;INS;ATP1A2;STX1A;ADCYAP1;PDX1;ATP1B2;FFAR1;RAB3A |
| GnRH signaling pathway | MAP2K6;GRB2A;GNRHR;GNAQ;CACNA1DA;MAP2K4;PRKCDA;CALM3B;CACNA1SB |
| Estrogen signaling pathway | SP1;PIK3CB;MAPK3;ITPR1;FKBP4;GABBR2;CALML5;GNAI3;PLCB1 |
| Melanogenesis | WNT5A;PRKACBA;CAMK2B1;PLCB3;Adcy4;GNA15.4;MC1R;CALM1;MITF |
| Thyroid hormone synthesis | TSHB;GPX1;PRKCA;GPX7;PLCB4;GPX6;TTF2;ATP1A3;PAX8 |
| Oxytocin signaling pathway | SRC;RYR2;CAMK2B;MAPK7;MYL6B;PPP3CA;CALM4;PRKCG;PPP3R2 |
| Renin secretion | GNAS;CALM3;AGTR1B;PLCB1;GNAQ;PRKG2;CALML5;ORAI1;REN |
| Aldosterone synthesis and secretion | CYP21A2;DDX1;CAMK1G;CAMK2G;CALM1;PRKCG;PRKACA;Adcy4;LIPE |
| Endocrine and other factor-regulated calcium reabsorption | DNM3;KLK1B22;ATP1A1;ATP1A3;VDR;FXYD2;KLK1B24;TRPV5;ATP1B2 |
| Salivary secretion | CALM2;CALM4;TRPV6;CALM3;GUCY1A3;LYZ2;GUCY1B3;STATH;PRKACG |
| Gastric acid secretion | CAMK2B;CAMK2G;SST;PLCB1;ATP1A4;KCNJ2;GAST;PLCB4;ATP1B4 |
| Pancreatic secretion | PLCB2;ATP1A3;PLA2G3;PRKCB;PNLIPRP1;RAP1A;SLC9A1;PLA2G1B;BST1 |
| Alzheimers disease | COX6B2;NDUFA1;PPP3CC;CASP12;UQCR11;COX8A;UQCR10;NDUFA11;ITPR1 |
| Huntingtons disease | NDUFAB1;NDUFB6;POLR2B;HTT;POLR2H;DNAH11;DNALC4;APAF1;UQCRC2 |
| Chagas disease (American trypanosomiasis) | PIK3CB;GNA14;GNAS;CD247;NOS2;PIK3CA;PLCB4;SERPINE1;PIK3R1 |
| African trypanosomiasis | Fasl;FASLG;APOL1;SELE;MYD88;IL1B;APOA1;TNF;HPR |
| Amoebiasis | ARG2;CD1D;PLCB4;TGFB2;TLR4;IL-8;PRKCB;COL27A1;LAMB4 |
| Pathways in cancer | SFPI1;FZD10;IL-8;TGFBR2;TRP53;MAPK1;NOS2;IKBKG;WNT9B |
GNAQ has several biochemical functions, for example, G-protein beta/gamma-subunit complex binding, GTP binding, GTPase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GNAQ itself. We selected most functions GNAQ had, and list some proteins which have the same functions with GNAQ. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein beta/gamma-subunit complex binding | GNA12A;GNA13A;CETN4;ADORA1;GNAQ;GNAI1;GNA11B;GNA11A;GNAL |
| GTP binding | NOA1;RAB10;RAB39BA;GTPBP8;GSPT2;TUBA1L;AK3;RAB11A;RAB30 |
| GTPase activator activity | NCKAP1L;LLGL1;USP6NL;FAM13B1;RIC8;SH3BGRL3;GIT2;ARHGDIA;JUN |
| GTPase activity | RAB3AB;RABL2B;GBP6;TUBB;ARF3;RASD1;RABL2A;ARL1;RAB11A |
| metal ion binding | APLF;EXTL3;PFKMA;SCNM1-PS;RXRGA;CBS;TDO2B;TRIM35-29;ENDOG |
| protein binding | MTA3;EWSR1;C1orf116;PELP1;PDCD6;HLTF;FASN;KLHL20;FAP |
| signal transducer activity | ZDHHC13;TAAR10A;TAS2R136;CXCR7B;GNB2;OLFR998;RGS6;TMTOPS3A;OLFR491 |
| type 2A serotonin receptor binding | GNA11;ARRB2;GNAQ |
GNAQ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNAQ here. Most of them are supplied by our site. Hope this information will be useful for your research of GNAQ.
RARA; ARRB1; PARP2; PECAM1; AGTR1; CXCR5; PPT1; LUM; ADHFE1; NT5C3A; pi3p; FLOT2; Myh10
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