gnb5
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  • Official Full Name
  • guanine nucleotide binding protein (G protein), beta 5
  • Background
  • Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternatively spliced transcript variants encoding different isoforms exist.
  • Synonyms
  • GNB5; guanine nucleotide binding protein (G protein), beta 5; guanine nucleotide-binding protein subunit beta-5; GB5; FLJ37457; FLJ43714; G protein beta 5 subunit; G protein beta subunit 5L; GB 5; GBB5_HUMAN; Gbeta5; GNB 5; Guanine nucleotide binding protein (G protein) beta 5; Guanine nucleotide binding protein beta 5; Guanine nucleotide binding protein beta 5 subunit; Guanine nucleotide binding protein beta subunit 5L; Guanine nucleotide binding protein subunit beta 5; Transducin beta chain 5; OTTHUMP00000162718; G protein, beta-5 subunit; G protein, beta subunit 5L; guanine nucleotide-binding protein, beta subunit 5L
Cat.#:GNB5-5058HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GNB5 Protein, GST-tagged
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Cat.#:GNB5-13358HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GNB5, GST-tagged
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Cat.#:GNB5-29091THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GNB5, His-tagged
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Cat.#:GNB5-7031MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GNB5 Protein
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Cat.#:GNB5-2604RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GNB5 Protein
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Cat.#:GNB5-5563CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GNB5
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Cat.#:GNB5-5859HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GNB5 293 Cell Lysate
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Involved Pathway

GNB5 involved in several pathways and played different roles in them. We selected most pathways GNB5 participated on our site, such as ADP signalling through P2Y purinoceptor 1, ADP signalling through P2Y purinoceptor 12, Activation of Kainate Receptors upon glutamate binding, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNB5 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ADP signalling through P2Y purinoceptor 1
MAPK14; GNB5
ADP signalling through P2Y purinoceptor 12
GNB5
Activation of Kainate Receptors upon glutamate binding
DLG4; DLG1L; NCALDA; DLG3; GNB5
Adrenaline,noradrenaline inhibits insulin secretion
ADCY6; GNB3B; ADRA2A; GNB5A; GNB5B; GNB3A; GNB5; ADRA2C
Alcoholism
HIST1H2BP; HDAC7; HDAC5; H2AFB3; CALM3; HIST1H2AC; DRD2; GNAS; MAP2K1; HIST1H3H
Aquaporin-mediated transport
AQP3B; ADCY8; ADCY9; MIP; AQP10; GNB5A; GNB5; PRKAR1AA; AQP8A.1; AQP11
Beta-catenin independent WNT signaling
ROR1; AGO1; AGO3; AP2B1; ITPR2; AP2A1; DVL1; AP2S1; AP2A2; PRICKLE1
Ca2+ pathway
AGO1; AGO2; AGO3; MOV10; GNB5

Protein Function

GNB5 has several biochemical functions, for example, G-protein gamma-subunit binding, GTPase activity, chaperone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GNB5 itself. We selected most functions GNB5 had, and list some proteins which have the same functions with GNB5. You can find most of the proteins on our site.
Function
Related Protein
Function G-protein gamma-subunit binding
Related Protein GNB5
Function GTPase activity
Related Protein DNM2A; RAB11B; GNA15; RAB5AB; TUBA4L; RAB38; RAB10; RAB36; MFN1B; MXG
Function chaperone binding
Related Protein DLST; CDC37L1; GRPEL1; BAG4; ERP29; AHSA2; SDF2L1; DNAJA3A; HYOU1; BIRC5
Function protein binding
Related Protein MED1; DLC1; CHERP; KCNA4; RNF111; MYO18A; LAPTM4B; TSNAX; C16orf59; MDFI
Function signal transducer activity
Related Protein GNG2; TAAR13B; TAAR7D; IRS4; GPR113; VMN2R116; CXCR7B; TAS2R109; PTGER1C; MRGPRA5

Interacting Protein

GNB5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNB5 here. Most of them are supplied by our site. Hope this information will be useful for your research of GNB5.
a8k1f4_human; GNG7; STIP1; MLF1; PSMD2; Usp19; HSP90AB1; q96be0_human; PFDN5; DNAJC7; AARSD1; PFDN2; NUDC; PSD; BNIP3L; EIF3J; OLFM2; ANXA7; RPA1; CDKN1A

GNB5 Related Articles

Fang, LT; Lee, S; et al. Comprehensive genomic analyses of a metastatic colon cancer to the lung by whole exome sequencing and gene expression analysis. INTERNATIONAL JOURNAL OF ONCOLOGY 44:211-221(2014).
Chen, YY; Zhou, CX; et al. Variations in target gene expression and pathway profiles in the mouse hippocampus following treatment with different effective compounds for ischemia-reperfusion injury. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 385:797-806(2012).