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GNPTAB

  • Official Full Name

    N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits

  • Overview

    This gene encodes two of three subunit types of the membrane-bound enzyme N-acetylglucosamine-1-phosphotransferase, a heterohexameric complex composed of two alpha, two beta, and two gamma subunits. The encoded protein is proteolytically cleaved at the Lys928-Asp929 bond to yield mature alpha and beta polypeptides while the gamma subunits are the product of a distinct gene (GeneID 84572). In the Golgi apparatus, the heterohexameric complex catalyzes the first step in the synthesis of mannose 6-phosphate recognition markers on certain oligosaccharides of newly synthesized lysosomal enzymes. These recognition markers are essential for appropriate trafficking of lysosomal enzymes. Mutations in this gene have been associated with both mucolipidosis II and mucolipidosis IIIA.
  • Synonyms

    GNPTAB; N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits; GNPTA; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta; KIAA1208; MGC4170; EC=2.7.8.17; GlcNAc-1-phosphotransferase subunits alpha/beta; GNPTA_HUMAN; N-acetylglucosamine-1-phosphotransferase subunit beta; Stealth protein GNPTAB; UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta; GlcNAc phosphotransferase; UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosamine; glucosamine (UDP-N-acetyl)-lysosomal-enzyme N-acetylglucosamine phosphotransferase; ICD;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Danio rerio (Zebrafish) (Brachydanio rerio)
  • Mouse
  • Mus musculus (Mouse)
  • Zebrafish
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Mouse GNPTAB-7053M Recombinant Mouse GNPTAB Protein Mammalian Cell His
Mouse GNPTAB-3785M Recombinant Mouse GNPTAB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse GNPTAB-3785M-B Recombinant Mouse GNPTAB Protein Pre-coupled Magnetic Beads HEK293
Danio rerio (Zebrafish) (Brachydanio rerio) RFL18454DF Recombinant Full Length Danio Rerio N-Acetylglucosamine-1-Phosphotransferase Subunits Alpha/Beta(Gnptab) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (894-1219)
Mus musculus (Mouse) RFL17649MF Recombinant Full Length Mouse N-Acetylglucosamine-1-Phosphotransferase Subunits Alpha/Beta(Gnptab) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (908-1235)
Zebrafish GNPTAB-3916Z Recombinant Zebrafish GNPTAB Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GNPTAB Related Articles

GNPTAB involved in several pathways and played different roles in them. We selected most pathways GNPTAB participated on our site, such as Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNPTAB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
LysosomeATP6V0A4;GBA;TCEAL4;AP4E1;PPT2;SORT1A;MANBA;LAPTM5;AP3D1

GNPTAB has several biochemical functions, for example, UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity, calcium ion binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GNPTAB itself. We selected most functions GNPTAB had, and list some proteins which have the same functions with GNPTAB. You can find most of the proteins on our site.

Function Related Protein
UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activityGNPTG;GNPTAB
calcium ion bindingNpnt;PLA2G12B;SERPINB1A;SRR;DHH;CANT1A;LTBP3;CA;CASQ1A
metal ion bindingHAGH;MTBL;Scd2;CYP2AA1;ZNF454;ZBTB33;ITGAM;CYP8B3;PM20D1
transcription factor bindingMSX2;FLNA;KAT8;Trl;TAF12;PPARG;BRD7;NLRP3;HDAC5
transferase activitySETDB1B;FUT9A;MGAT1B;EPHA4A;ZDHHC1;PHKG1A;ST6GALNAC1.2;B3GNT7L;ALG6
transferase activity, transferring phosphorus-containing groupsCKBA;CKMT2A;CKBB;CKMA;CKMB;CKMT2B;GNPTAB;CKMT1

GNPTAB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNPTAB here. Most of them are supplied by our site. Hope this information will be useful for your research of GNPTAB.

Chen, H; Xu, JQ; et al. Association study of stuttering candidate genes GNPTAB, GNPTG and NAGPA with dyslexia in Chinese population. BMC GENETICS 16:-(2015).
Qian, Y; van Meel, E; et al. Analysis of Mucolipidosis II/III GNPTAB Missense Mutations Identifies Domains of UDP-GlcNAc: lysosomal Enzyme GlcNAc-1-phosphotransferase Involved in Catalytic Function and Lysosomal Enzyme Recognition. JOURNAL OF BIOLOGICAL CHEMISTRY 290:3045-3056(2015).
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