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GOT2

  • Official Full Name

    glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)

  • Overview

    Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively.GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology.
  • Synonyms

    GOT2; glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); aspartate aminotransferase, mitochondrial; KAT4; KATIV; kynurenine aminotransferase IV; mitAAT; ASPATA; FABP pm; Got 2; MGC102129; MGC115763; mitochondrial; AATM_HUMAN; AL022787; Aspartate aminotransferase; Aspartate aminotransferase 2; EC 2.6.1.1; FABP 1; FABP-1; FABPpm; Fatty acid binding protein; Fatty acid-binding protein; FLJ40994; Glutamate oxaloacetate transaminase 2; Glutamate oxaloacetate transaminase 2, mitochondrial; Glutamate oxaloacetate transaminase, mitochondrial; Glutamic oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); mAspAT; Mitochondrial aspartate aminotransferase; OTTMUSP00000017748; Plasma membrane fatty acid binding protein; Plasma membrane-associated fatty acid-binding protein; Transaminase A;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GOT2-26H Active Recombinant Human GOT2 protein, His-tagged E.coli His
Human GOT2-13399H Recombinant Human GOT2, His-tagged E.coli His 82-430a.a.
Human GOT2-302HCL Recombinant Human GOT2 lysate HEK293 N/A
Human GOT2-3055H Recombinant Human GOT2 Protein (Ser30-Lys430), N-His tagged E.coli N-His Ser30-Lys430
Human GOT2-5128H Recombinant Human GOT2 Protein, GST-tagged Wheat Germ GST
Human GOT2-5446HF Recombinant Full Length Human GOT2 Protein, GST-tagged In Vitro Cell Free System GST 430 amino acids
Mouse Got2-3669M Recombinant Mouse Got2, His-tagged E.Coli or Yeast His 430
Mouse Got2-1028M Recombinant Mouse Got2 protein, His-tagged E.coli His Ser30~Lys430 (Accession # P05202)
Mouse GOT2-7080M Recombinant Mouse GOT2 Protein Mammalian Cell His
Mouse GOT2-3804M Recombinant Mouse GOT2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse GOT2-3804M-B Recombinant Mouse GOT2 Protein Pre-coupled Magnetic Beads HEK293
Rat GOT2-2624R Recombinant Rat GOT2 Protein Mammalian Cell His
Rat GOT2-2279R Recombinant Rat GOT2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat GOT2-2279R-B Recombinant Rat GOT2 Protein Pre-coupled Magnetic Beads HEK293
Bovine GOT2-1994B Recombinant Bovine GOT2 Protein (20-430 aa), His-SUMO-tagged E.coli His/SUMO 20-430 aa
Cynomolgus Monkey GOT2-558C Recombinant Cynomolgus GOT2 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey GOT2-303C-B Recombinant Cynomolgus Monkey GOT2 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey GOT2-303C Recombinant Cynomolgus Monkey GOT2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken GOT2-7071C Recombinant Chicken GOT2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GOT2 Related Articles

GOT2 involved in several pathways and played different roles in them. We selected most pathways GOT2 participated on our site, such as Arginine biosynthesis, Alanine, aspartate and glutamate metabolism, Cysteine and methionine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GOT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Arginine biosynthesisGLULB;ybaS;NOS2;NOS2A;NOS1;ARG1;GOT2;GLS;GOT2A
Alanine, aspartate and glutamate metabolismRIMKLB;GPT;GPT2L;ADSS;FOLH1;GLULC;ADSSL1;ADSSL;NAT8L
Cysteine and methionine metabolismMAT2AL;LDHB;TAT;AMD1;GOT2;CBSA;CTH;DNMT3AA;MTAP
Arginine and proline metabolismALDH3A2;LAP3;NOS1;PYCRL;CKMT2;OAT;AOC1;ARG2;P4HA1
Tyrosine metabolismALDH3B1;COMTA;AOX4;TYRP1;TPO;AOC2;TAT;GOT2A;ALDH3A1
Phenylalanine metabolismGOT2B;GOT2A;GOT1;GOT2;MAOA;MAOB;ALDH1A3;TAT;GM4952
Phenylalanine, tyrosine and tryptophan biosynthesisTAT;IL4I1;GOT2B;GOT1;GOT2;GOT2A;PAH
Metabolic pathwaysPOLE;CYP4A10;INPP4AB;SPR;ATP5G3B;ADO;UQCR11;NAGLU;GALNT4
Carbon metabolismME1;ACO2;HAO2;PGD;PRPS1;IDH3A;SUCLG1;PFKP;ACADS
-Oxocarboxylic acid metabolismBCAT1;GPT2L;GOT1;GOT2;IDH3G;ACO1;IDH1;AADAT;ACY1
Biosynthesis of amino acidsIDH3B;MAT2AB;ACO2;PFKP;SDSL;ENO1B;ASL;IDH1;ALDOA
Fat digestion and absorptionAGPAT1;CD36;ACAT2;FABP2;PPAP2C;PPAP2B;APOA1;PLA2G2F;PLA2G3

GOT2 has several biochemical functions, for example, L-aspartate:2-oxoglutarate aminotransferase activity, L-phenylalanine:2-oxoglutarate aminotransferase activity, amino acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GOT2 itself. We selected most functions GOT2 had, and list some proteins which have the same functions with GOT2. You can find most of the proteins on our site.

Function Related Protein
L-aspartate:2-oxoglutarate aminotransferase activityGOT2A;GOT2B;GOT1L1;GOT2;GOT1
L-phenylalanine:2-oxoglutarate aminotransferase activityGOT2B;GOT2;GOT1;GOT2A;TAT
amino acid bindingDDAH1;TPH1;GOT2;TPH1A;AARS2;OTC;DPYS;TAT;KARS
enzyme bindingPCCA;C6orf211;CYP1A2;PARP4;P4HB;CDK19;A2M;ATG3;PIAS1
identical protein bindingCALCA;ALDOB;DPP9;MUL1A;ADORA2A;ADIPOQ;MTPAP;COL7A1;BNIP2
kynurenine-oxoglutarate transaminase activityAADAT;CCBL2;CCBL1;GOT2
phospholipid bindingOTC;FABP1;NSMAF;PTAFR;APOH;SEC14L2;PREX1;PAFAH2;PRKCI
poly(A) RNA bindingH2-Q10;RBM27;YARS;ZNF385A;CSTF3;HIST4H4;SORBS2;YTHDF1;YWHAG
protein homodimerization activityATPIF1;PKD2;LILRB1;PGCP;CECR1;SFTPC;ADD1;LRRK2;S100A5
pyridoxal phosphate bindingGAD2;CTH;PYGMB;PYGB;LOC650128;SHMT1;GOT1;NFS1;AGXT2

GOT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GOT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GOT2.

EIF1B; BCAR3; GH1; EPB41; VDAC1; MCC; CDK2; MPG; HLA-B; HLA-C; ARF6; CCNA1; PAK2; Bles03; ATG5; CTNNBIP1; FTSJ1; TNIK; PACSIN3; PRKAB1

Han, QA; Cai, T; et al. Thermal stability, pH dependence and inhibition of four murine kynurenine aminotransferases. BMC BIOCHEMISTRY 11:-(2010).
Han, Q; Cai, T; et al. Structure, expression, and function of kynurenine aminotransferases in human and rodent brains. CELLULAR AND MOLECULAR LIFE SCIENCES 67:353-368(2010).
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