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GPAA1

  • Official Full Name

    glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast)

  • Overview

    Posttranslational glycosylphosphatidylinositol (GPI) anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. The protein encoded by this gene presumably functions in GPI anchoring at the GPI transfer step. The mRNA transcript is ubiquitously expressed in both fetal and adult tissues. The anchor attachment protein 1 contains an N-terminal signal sequence, 1 cAMP- and cGMP-dependent protein kinase phosphorylation site, 1 leucine zipper pattern, 2 potential N-glycosylation sites, and 8 putative transmembrane domains.
  • Synonyms

    GPAA1; glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast); anchor attachment protein 1 (Gaa1p, yeast) homolog , GPAA1P anchor attachment protein 1 homolog (yeast); glycosylphosphatidylinositol anchor attachment 1 protein; GAA1; GPI transamidase subunit; hGAA1; GPI anchor attachment protein 1; GAA1 protein homolog; GPAA 1; GPAA1P anchor attachment protein 1 homolog; glycophosphatidylinositol anchor attachment 1; anchor attachment protein 1 (Gaa1p, yeast) homolog;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rhesus Macaque
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GPAA1-13405H Recombinant Human GPAA1, GST-tagged E.coli GST 62-321a.a.
Human GPAA1-5819HCL Recombinant Human GPAA1 293 Cell Lysate HEK293 N/A
Human GPAA1-5137H Recombinant Human GPAA1 Protein, GST-tagged Wheat Germ GST
Human GPAA1-5491HF Recombinant Full Length Human GPAA1 Protein, GST-tagged In Vitro Cell Free System GST 621 amino acids
Mouse GPAA1-7087M Recombinant Mouse GPAA1 Protein Mammalian Cell His
Mouse GPAA1-3811M Recombinant Mouse GPAA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse GPAA1-3811M-B Recombinant Mouse GPAA1 Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL20979HF Recombinant Full Length Human Glycosylphosphatidylinositol Anchor Attachment 1 Protein(Gpaa1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-621)
Mus musculus (Mouse) RFL23393MF Recombinant Full Length Mouse Glycosylphosphatidylinositol Anchor Attachment 1 Protein(Gpaa1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-621)
Rhesus Macaque GPAA1-1926R Recombinant Rhesus monkey GPAA1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque GPAA1-1746R Recombinant Rhesus Macaque GPAA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque GPAA1-1746R-B Recombinant Rhesus Macaque GPAA1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GPAA1 Related Articles

GPAA1 involved in several pathways and played different roles in them. We selected most pathways GPAA1 participated on our site, such as Glycosylphosphatidylinositol(GPI)-anchor biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPAA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycosylphosphatidylinositol(GPI)-anchor biosynthesisPIGU;PIGB;PIGF;PIGM;PIGC;PIGL;PIGH;PIGK;PIGO
Metabolic pathwaysUGT1AB;AGPAT6;HMBSB;AMY2A2;GAA;MDH1AA;UPP2;SMPD3;GBA

GPAA1 has several biochemical functions, for example, contributes_to GPI anchor binding, contributes_to GPI-anchor transamidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GPAA1 itself. We selected most functions GPAA1 had, and list some proteins which have the same functions with GPAA1. You can find most of the proteins on our site.

Function Related Protein
contributes_to GPI anchor bindingPIGK;GPAA1
contributes_to GPI-anchor transamidase activityPIGS;GPAA1
protein bindingFGF19;SUFU;CSF1;C7orf59;NETO2;XPA;GALR2;FUS;MYEF2
tubulin bindingAGBL5;STMN2B;STMN2;PARK2;VBP1;MAP1S;EML1;FYN;MTAP7D3

GPAA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPAA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPAA1.

ALPP; EIF3E; PIN1; GRIK5; PRR13; Ptpn13; Rock1; PIGS

Sharma, DK; Hilley, JD; et al. Soluble GP18 restores glycosylphosphatidylinositol anchoring in a trypanosome cell-free system depleted of lumenal endoplasmic reticulum proteins. BIOCHEMICAL JOURNAL 351:717-722(2000).
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