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GPHN

  • Official Full Name

    gephyrin

  • Overview

    This gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described; however, the full-length nature of all transcript variants is not currently known.
  • Synonyms

    GPHN; gephyrin; KIAA1385; Domain E; Domain G; GEPH; GEPH_HUMAN; GPH; GPHRYN; Molybdopterin molybdenumtransferase; MPT adenylyltransferase; MPT Mo-transferase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GPHN-13423H Recombinant Human GPHN, GST-tagged E.coli GST N-term-315a.a.
Human GPHN-5807HCL Recombinant Human GPHN 293 Cell Lysate HEK293 N/A
Human GPHN-1009H Recombinant Human GPHN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human GPHN-873HFL Recombinant Full Length Human GPHN Protein, C-Flag-tagged Mammalian cells Flag
Human GPHN-1009H-B Recombinant Human GPHN Protein Pre-coupled Magnetic Beads HEK293
Human GPHN-5155H Recombinant Human GPHN Protein, GST-tagged Wheat Germ GST
Human GPHN-2749H Recombinant Human GPHN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human GPHN-2675H Recombinant Human GPHN protein, His-tagged E.coli His 1-315 aa
Mouse Gphn-3288M Recombinant Mouse Gphn Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat GPHN-2639R Recombinant Rat GPHN Protein Mammalian Cell His
Rat GPHN-2293R Recombinant Rat GPHN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat GPHN-2293R-B Recombinant Rat GPHN Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque GPHN-1934R Recombinant Rhesus monkey GPHN Protein, His-tagged Mammalian Cell His
Rhesus Macaque GPHN-1754R Recombinant Rhesus Macaque GPHN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque GPHN-1754R-B Recombinant Rhesus Macaque GPHN Protein Pre-coupled Magnetic Beads HEK293
Chicken GPHN-3193C Recombinant Chicken GPHN Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GPHN Related Articles
  • GPHN Related Research Area

GPHN involved in several pathways and played different roles in them. We selected most pathways GPHN participated on our site, such as GABAergic synapse, Metabolism, Metabolism of vitamins and cofactors, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPHN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
GABAergic synapseGABRB1;PRKCA;GABARAPL2;GABRE;GABRA2;GNG3;SLC38A3;PRKACG;GNG11
MetabolismACOT11;ADSS;KCNG4;SLC25A15A;PFKLB;ATP5H;CHAT;SLC25A12;GGT6
Metabolism of vitamins and cofactorsSLC5A6B;SLC46A1;NAMPT;LOC100686744;SLC25A16;CD320;PDZD11;GPHNA;SLC5A6A
Metabolism of water-soluble vitamins and cofactorsCD320;CYB5R3;SLC5A6A;GPHN;ELA2L;TCN1;GSTO2;CBLC-1;SLC25A32A
Molybdenum cofactor biosynthesisMOCOS;GPHN;GPHNA

GPHN has several biochemical functions, for example, ATP binding, metal ion binding, molybdopterin adenylyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GPHN itself. We selected most functions GPHN had, and list some proteins which have the same functions with GPHN. You can find most of the proteins on our site.

Function Related Protein
ATP bindingTYRO3;DDX53;PFKFB1;PRPS1L1;CDKL3;SNRNP200;ITPKA;TGFBR1B;HSPA8
metal ion bindingDGKE;ZFP583;PDE4C;Scd1;OMA1;AFP;NDUFV2;ZNF486;PRDM8B
molybdopterin adenylyltransferase activityGPHN;GPHNB
molybdopterin molybdotransferase activityGPHN;GPHNB

GPHN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPHN here. Most of them are supplied by our site. Hope this information will be useful for your research of GPHN.

DYNLL1; PRPF4; Dynll1; OTUD4; ACADVL; KHDRBS1; SPATS1; SLX4; CDCA5

Petit-Pedrol, M; Armangue, T; et al. Encephalitis with refractory seizures, status epilepticus, and antibodies to the GABA(A) receptor: a case series, characterisation of the antigen, and analysis of the effects of antibodies. LANCET NEUROLOGY 13:276-286(2014).
Notter, T; Panzanelli, P; et al. A protocol for concurrent high-quality immunohistochemical and biochemical analyses in adult mouse central nervous system. EUROPEAN JOURNAL OF NEUROSCIENCE 39:165-175(2014).
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