gps1
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  • Official Full Name
  • G protein pathway suppressor 1
  • Background
  • This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • GPS1; G protein pathway suppressor 1; COP9 signalosome complex subunit 1; COPS1; CSN1; 5S342; Arabidopsis Fus6/Cop 11 homolog; constitutive photomorphogenic homolog subunit 1; COP9; CSN 1; CSN1_HUMAN; GPS-1; JAB1-containing signalosome subunit 1; MFH protein; Protein GPS1; Protein MFH; SGN1; Signalosome subunit 1; Y59A8A.1
Cat.#:GPS1-5294HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GPS1 Protein, GST-tagged
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Cat.#:GPS1-563CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus GPS1 Protein, His-tagged
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Cat.#:GPS1-1355CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GPS1
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Cat.#:GPS1-4842ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GPS1
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Cat.#:GPS1-5766HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GPS1 293 Cell Lysate
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Involved Pathway

GPS1 involved in several pathways and played different roles in them. We selected most pathways GPS1 participated on our site, such as DNA Damage Recognition in GG-NER, DNA Repair, Formation of TC-NER Pre-Incision Complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
DNA Damage Recognition in GG-NER
INO80B; COPS7A; ACTR5; COPS5; COPS8; GPS1; YY1; INO80C; PARP1; DDB1
DNA Repair
RAD9A; CETN2; EYA3; UIMC1; EME2; YY1A; INO80; BAZ1B; TDP1; PPP4R2
Formation of TC-NER Pre-Incision Complex
PPIE; COPS5; ZNF830; COPS4; COPS3; DDB1; GPS1; COPS8; TCEA1; COPS7A
Global Genome Nucleotide Excision Repair (GG-NER)
COPS6; INO80E; YY1A; DDB2; USP45; YY1; ACTL6A; COPS4; COPS2; NFRKB
Nucleotide Excision Repair
GTF2H3; ERCC5; ERCC4; ERCC1; BIVM-ERCC5; MCRS1; TFPT; XPA; POLE; PCNA
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
GPS1; ERCC8; COPS7B; KIAA1530; COPS4; COPS2; ZFP830; COPS3; COPS7A; COPS8

Protein Function

GPS1 has several biochemical functions, for example, GTPase inhibitor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GPS1 itself. We selected most functions GPS1 had, and list some proteins which have the same functions with GPS1. You can find most of the proteins on our site.
Function
Related Protein
Function GTPase inhibitor activity
Related Protein CDC42SE1; UBE4A; TNK2; RTKN; PDE6D; GPS2; RHOH; SLIT2; IPO5; GPS1
Function protein binding
Related Protein KRT4; HTR3C; PRDM16; ACO1; HMGB3; LEF1; BLVRA; NR2F1; OTUD7B; SPOPL

Interacting Protein

GPS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPS1.
COPS5; GFER; COPS6; COPS3; Ddb1; WRAP73; q7cgv8_yerpe; q81tm9_bacan; TBC1D17; EGFR; GAPDH