GPS1
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Official Full Name
G protein pathway suppressor 1
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Overview
This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
GPS1; G protein pathway suppressor 1; COP9 signalosome complex subunit 1; COPS1; CSN1; 5S342; Arabidopsis Fus6/Cop 11 homolog; constitutive photomorphogenic homolog subunit 1; COP9; CSN 1; CSN1_HUMAN; GPS-1; JAB1-containing signalosome subunit 1; MFH protein; Protein GPS1; Protein MFH; SGN1; Signalosome subunit 1; Y59A8A.1;
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- Zebrafish
- E. coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- C
- His
- GST
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
GPS1 involved in several pathways and played different roles in them. We selected most pathways GPS1 participated on our site, such as DNA Damage Recognition in GG-NER, DNA Repair, Formation of TC-NER Pre-Incision Complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA Damage Recognition in GG-NER | YY1;MCRS1;NFRKB;TFPT;PARP1;COPS3;DDB2;COPS4;COPS7B |
| DNA Repair | KIAA0146;ZNF830;ELL;CHEK1;ASCC3;DDB2;EME2;HUS1;CLSPN |
| Formation of TC-NER Pre-Incision Complex | COPS4;COPS5;ZNF830;ERCC8;GPS1;COPS8;DDB1;PPIE;COPS7B |
| Global Genome Nucleotide Excision Repair (GG-NER) | COPS6;INO80E;CHD1L;INO80;YY1;PIAS3;INO80C;MCRS1;GPS1 |
| Nucleotide Excision Repair | ERCC3;RAD23B;GTF2H2C_2;RPA3;POLE4;RPA2;INO80C;COPS7A;RAD23AB |
| Transcription-Coupled Nucleotide Excision Repair (TC-NER) | COPS7A;COPS3;KIAA1530;COPS6;ZFP830;COPS4;PPIE;COPS7B;GPS1 |
GPS1 has several biochemical functions, for example, GTPase inhibitor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GPS1 itself. We selected most functions GPS1 had, and list some proteins which have the same functions with GPS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase inhibitor activity | ARL2;GPS2;GPS1;TNK2;UBE4A;RHOH;CPEB2;CDC42SE1;RTKN |
| protein binding | MED10;BCL2L16;RILP;ZDHHC17;S100A12;AKR1A1;NAALADL2;DOCK4;TIMM21 |
GPS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPS1.
COPS5; GFER; COPS6; COPS3; Ddb1; WRAP73; q7cgv8_yerpe; q81tm9_bacan; TBC1D17; EGFR; GAPDH
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