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GPS2

Official Full Name

G protein pathway suppressor 2
Overview

This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function.
Synonyms

GPS2; G protein pathway suppressor 2; GPS-2; AMF-1; MGC104294; MGC119287; MGC119288; MGC119289;

Type

Cell & Tissue Lysates
Recombinant Proteins

Species

Human
Mouse
Zebrafish

Source

HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
Myc
DDK
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GPS2-306HCL	Recombinant Human GPS2 lysate	HEK293	N/A		Inquiry
Human	GPS2-6569H	Recombinant Human GPS2 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	GPS2-2243H	Recombinant Human GPS2 Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	GPS2-5296H	Recombinant Human GPS2 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	GPS2-5560HF	Recombinant Full Length Human GPS2 Protein, GST-tagged	In Vitro Cell Free System	GST	327 amino acids	Inquiry
Mouse	Gps2-3297M	Recombinant Mouse Gps2 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Zebrafish	GPS2-11208Z	Recombinant Zebrafish GPS2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

GPS2 involved in several pathways and played different roles in them. We selected most pathways GPS2 participated on our site, such as HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
HTLV-I infection	PIK3CA;ELK4;FZD3;BUB1B;Adcy4;ANAPC4;ICAM1;Fzd4;FZD1

GPS2 has several biochemical functions, for example, GTPase inhibitor activity, protein binding, transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GPS2 itself. We selected most functions GPS2 had, and list some proteins which have the same functions with GPS2. You can find most of the proteins on our site.

Function	Related Protein
GTPase inhibitor activity	ARL2;IPO5;CDC42SE1;GPS1;PDE6D;UBE4A;GPS2;CPEB2;TNK2
protein binding	STX6;HAAO;JAM2A;SSH1;NR0B2;EXOSC8;PPFIA4;KLRB1F;C22orf39
transcription corepressor activity	NOC2L;MXI1;DNMT3B;POU1F1;SFMBT1;YWHAB;MXD4;HIRA;SIRT1

GPS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPS2.

E6; E6; ATF4; KRT31