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Gnas

  • Official Full Name

    GNAS complex locus

  • Overview

    This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and;biallelically expressed transcripts that are derived from four alternative promoters and 5 exons. Some transcripts;contain a differentially methylated region (DMR) at their 5 exons, and this DMR is commonly found in imprinted genes;and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the;opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally;expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a;second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream;exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of;the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase;and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this;gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright;hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia,;polyostotic fibrous dysplasia of bone, and some pituitary tumors.
  • Synonyms

    GNAS; GNAS complex locus; Adenylate cyclase stimulating G alpha protein; Guanine nucleotide binding protein G(s) alpha subunit; neuroendocrine secretory protein 55; adenylate cyclase-stimulating G alpha protein; guanine nucleotide-binding protein G(s) subunit alpha isoforms; guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1; GNAS1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • SUMO
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GNAS-192H Active Recombinant Human GNAS protein, GST-tagged E.coli GST
Human GNAS-1264H Recombinant Human GNAS, GST-tagged E.coli GST 230-394aa
Human GNAS-5866HCL Recombinant Human GNAS 293 Cell Lysate HEK293 N/A
Human GNAS-5048H Recombinant Human GNAS Protein, GST-tagged Wheat Germ GST
Human GNAS-1423H Recombinant Human GNAS Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human GNAS-2754H Recombinant Human GNAS Protein, His-tagged E.coli N-His Gly2-Leu394
Human GNAS-999H Recombinant Human GNAS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human GNAS-4664H Recombinant Human GNAS Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human GNAS-3643H Recombinant Human GNAS protein, His-tagged E.coli His 230-394 aa
Human GNAS-363HFL Recombinant Full Length Human GNAS Protein, C-Flag-tagged Mammalian cells Flag
Human GNAS-5336HF Recombinant Full Length Human GNAS Protein, GST-tagged In Vitro Cell Free System GST 394 amino acids
Human GNAS-5415H Recombinant Human GNAS Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human GNAS-999H-B Recombinant Human GNAS Protein Pre-coupled Magnetic Beads HEK293
Human GNAS-4085H Recombinant Human GNAS protein, His-SUMO-tagged E.coli His-SUMO 1-394aa
Human GNAS-2440H Recombinant Human GNAS Protein (Met1-Leu394), N-His tagged E.coli N-His Met1-Leu394
Mouse GNAS-7020M Recombinant Mouse GNAS Protein Mammalian Cell His
Mouse GNAS-3762M Recombinant Mouse GNAS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse GNAS-3762M-B Recombinant Mouse GNAS Protein Pre-coupled Magnetic Beads HEK293
Mouse Gnas-3259M Recombinant Mouse Gnas Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Gnas-1045R Recombinant Rat GNAS Complex Locus Sf9 Insect Cell N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Gnas Related Articles
  • Gnas Related Research Area

Gnas involved in several pathways and played different roles in them. We selected most pathways Gnas participated on our site, such as Rap signaling pathway, Calcium signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Gnas were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Rap signaling pathwayRRAS;AKT2;ACTB;PRKCI;PIK3R2;KRIT1;P2RY1;RHOA;LPAR5
Calcium signaling pathwayGRIN1B;LHCGR;MYLK3;SPHK2;GNA14;ADRB1;ITPR3;ADORA2A;PPP3R2
cAMP signaling pathwayGRIN2B;PRKACG;ATP1B1;LIPE;F2R;PLN;LOC100328615;CREB3L1;CREB3L2
Phospholipase D signaling pathwayPLA2G4C;AKT2;LPAR5;GAB2;INS;PIK3R1;KIT;PRKCA;MAPK3
Adrenergic signaling in cardiomyocytesCALM3A;CAMK2D;AGTR1A;PPP2R5D;CACNG7;PIK3R3B;BCL2;ATP2B1;CALM1A
Vascular smooth muscle contractionRHOAC;PRKCG;PLA2G10;ARAF;PRKACBA;MAP2K2A;PPP1CB;PRKCD;PRKCE
Gap junctionMAP2K2;GRB2A;HRASB;TUBA3D;TUBA1B;CX35B;TUBB6;GJA1;GNA15.1
Platelet activationPLCG2;STIM1;ROCK1;PIK3CD;FYN;FCER1G;PRKG1;PLCB3;PRKACA
Circadian entrainmentCALM1;NOS1AP;AKR1C1;PLCB3;FOS;GRIA1;GRIN1;PRKG1;MAPK3
Glutamatergic synapseGLS2;PRKCG;GRIK2;GRIK4;PRKACG;GRIK5;SLC17A7;PLCB2;PRKACB
Serotonergic synapsePRKCA;GNGT2;ALOX12B;PLA2G4A;ITPR1;PLCB1;GNG12;Casp3;KCNN2
Dopaminergic synapseMAPK8;PRKACB;CAMK2G;PPP1CC;GNAI1;PPP2CA;PPP2R2A;ARRB2;AKT2
Long-term depressionPLCB4;PLCB2;GRIA2;KRAS;GNAZ;PPP1R17;GRIA1;RAF1;NOS1
Taste transductionTAS2R110;TRPM5;TAS2R113;GNAT3;TAS1R2;TAS2R126;TAS2R138;TAS2R109;TAS2R130
Inflammatory mediator regulation of TRP channelsTRPV2;CYP4A14;CAMK2G;PRKACB;CALM4;PLCG1;CYP2C55;MAPK12;CYP2C50
Insulin secretionGNAS;ATP1B2;PCLO;ATP1B1;ATP1A3;KCNMB4;Adcy4;ATF4;CAMK2D
GnRH signaling pathwayPRKCA;ELK1;PLCB4;ADCY1A;CDC42L;MAPK1;MAPK14A;MMP14B;MAPK3
Ovarian steroidogenesisPRKACA;HSD17B2;PRKACB;ALOX5;PLA2G4A;PLA2G4C;PRKACG;HSD3B5;Adcy4
Estrogen signaling pathwayKCNJ3;RAF1;Adcy4;HSPA1A;PRKACA;GNAI3;HSPA8;GNAQ;GRB2
MelanogenesisCREB3L3A;CALM2A;MAP2K2;MITFB;TCF7L2;PLCB2;KIT;CAMK2D2;WNT5A
Thyroid hormone synthesisATP1B1;PAX8;GPX1;HSPA5;PLCB3;GPX5;GSR;CREB3L2;GNAQ
Oxytocin signaling pathwayCACNB3;KCNJ14;SRC;PIK3CA;PLCB4;NPR1;PLA2G4D;ROCK1;HRAS
Regulation of lipolysis in adipocytesPIK3R1;PIK3CG;PIK3R2;TSHB;TSHR;PRKG2;ABHD5;PIK3CB;AKT1
Renin secretionAGTR1A;PLCB2;GNAI2;CLCA4;PLCB4;PDE1C;CALML5;REN;PRKG2
Aldosterone synthesis and secretionORAI1;AGTR1A;CYP21A2;MC2R;PLCB3;SCARB1;ADCY1;NR4A2;NETO2
Endocrine and other factor-regulated calcium reabsorptionGNAQ;BDKRB2;KLK2;ATP2B1;KLK1B5;ATP1B1;KLK1B11;KLK1B9;PRKACB
Salivary secretionCAP18;CALM4;PRKG1;PRKACB;CALML5;ATP1A1;SLC9A1;PLCB2;AMY1B
Gastric acid secretionAdcy4;PRKACA;CAMK2G;EZR;SST;PLCB2;ATP1A3;KCNE2;ATP1A1
Pancreatic secretionCLCA3;TPCN2;PRKCG;CELA3A;PRSS1;CLCA2;ATP2A2;GNAQ;CPB1
Bile secretionSLC4A4;ABCB11;LDLR;SLC22A8;ADCY6;ATP1A1;SLC22A1;AQP4;SLC2A1
Cocaine addictionSLC18A2;GRIN1;MAOA;CREB5;SLC18A1;GNAI3;NFKB1;DRD1;GNAI2
AlcoholismHRAS;HIST1H4E;CALML5;H2AFZ;HIST2H3C2;HIST3H2A;HIST1H2BL;GNB4;H2AFX
Vibrio cholerae infectionATP6V0C;ACTB;ATP6V1G1;SEC61G;ACTG1;ATP6V0D2;ATP6V1B1;PLCG1;PRKACB
Chagas disease (American trypanosomiasis)PPP2R2C;IL1B2;PLCB1;AKT1;PPP2R2D;MYD88;FAS;IFNGR2;TLR2
AmoebiasisC8A;SERPINB2;GNA11;RAB7A;GNAL;IL10;PRKACB;ARG1;SERPINB1A
Pathways in cancerRBX1;PIK3CD;PIK3R2;MAPK9;ITGAV;PIK3CG;LPAR3;NTRK1;BIRC3
Dilated cardiomyopathyPLN;SLC8A1;TNNI3;RYR2;ITGA8;TNF;ITGB4;CACNA2D2;CACNG2

Gnas has several biochemical functions, for example, D1 dopamine receptor binding, G-protein beta/gamma-subunit complex binding, GTP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Gnas itself. We selected most functions Gnas had, and list some proteins which have the same functions with Gnas. You can find most of the proteins on our site.

Function Related Protein
D1 dopamine receptor bindingATP1A3;PTPN11;DRD3;GNAS;AGTR1A;CAV2;DLG4;ARRB2
G-protein beta/gamma-subunit complex bindingGNAO1;GNA11;GNAV1;GNA12;GNAO1A;GNA13;Adcy4;GNA15;GNAI2B
GTP bindingARHGAP5;ATL3;RAB11BA;RAP1AB;ARL5B;RHOAB;MTG1;RAP1AA;MX2
GTPase activityTUBA2;GNGT2;RAP1B;RRAGC;GNAI3;ARL8B;TUBG2;DNM3A;MFN1B
adenylate cyclase activityADCY3;ADCY6;ADCY1B;ADCY1;ADCY8;ADCY9;Adcy4;ADCY7;ADCY1A
beta-2 adrenergic receptor bindingBDKRB2;SLC9A3R1;PDE4D;GNAS;NEDD4
corticotropin-releasing hormone receptor 1 bindingGNAS;GNAO1B;GNAO1A;UCN;GNAO1;CRH
insulin-like growth factor receptor bindingREN;INS;INS2;IGF2A;Ren1;IGF3;GNAS;SOCS1;INSL4
ionotropic glutamate receptor bindingDLG2;SHANK1;SHANK2;DLG4;RAB4A;CACNG2;ADRB2;DLG4B;DLG1
metal ion bindingZNF74;TNNI3;CA15B;CHAMP1;CLCA1;GNAQ;ZUFSP;ATP12A;KARS
molecular_functionGM1673;TLK1;VWDE;C8orf42;DEFB11;CCDC57;TRANK1;TIFAB;GPM6B
mu-type opioid receptor bindingGNAS;GPR177;GNAO1A;FLNA;GNAO1B;GNAO1;WLS
protein bindingCOMMD5;CDK10;TIMM8A;GPR37;HYPK;FGF12;TBX15;PSMD7;HYLS1
signal transducer activityMAPKAPK5;VIPR1B;OMP;GNRHR1;OLFR78;ADCYAP1R1A;LGALS9;APLNRB;STAT5B

Gnas has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Gnas here. Most of them are supplied by our site. Hope this information will be useful for your research of Gnas.

Zeng, WH; Xu, JJ; et al. Pseudohypoparathyroidism with Hashimoto's thyroiditis and Turner syndrome: a case report. GYNECOLOGICAL ENDOCRINOLOGY 30:694-696(2014).
Pierce, M; Sandrock, R; et al. Measurement of thyroid stimulating immunoglobulins using a novel thyroid stimulating hormone receptor-guanine nucleotide-binding protein, (GNAS) fusion bioassay. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 170:115-121(2012).
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