Gnas
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Official Full Name
GNAS complex locus
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Overview
This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and;biallelically expressed transcripts that are derived from four alternative promoters and 5 exons. Some transcripts;contain a differentially methylated region (DMR) at their 5 exons, and this DMR is commonly found in imprinted genes;and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the;opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally;expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a;second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream;exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of;the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase;and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this;gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright;hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia,;polyostotic fibrous dysplasia of bone, and some pituitary tumors. -
Synonyms
GNAS; GNAS complex locus; Adenylate cyclase stimulating G alpha protein; Guanine nucleotide binding protein G(s) alpha subunit; neuroendocrine secretory protein 55; adenylate cyclase-stimulating G alpha protein; guanine nucleotide-binding protein G(s) subunit alpha isoforms; guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1; GNAS1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- SUMO
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- Gnas Related Articles
- Gnas Related Research Area
Gnas involved in several pathways and played different roles in them. We selected most pathways Gnas participated on our site, such as Rap signaling pathway, Calcium signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Gnas were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Rap signaling pathway | RRAS;AKT2;ACTB;PRKCI;PIK3R2;KRIT1;P2RY1;RHOA;LPAR5 |
Calcium signaling pathway | GRIN1B;LHCGR;MYLK3;SPHK2;GNA14;ADRB1;ITPR3;ADORA2A;PPP3R2 |
cAMP signaling pathway | GRIN2B;PRKACG;ATP1B1;LIPE;F2R;PLN;LOC100328615;CREB3L1;CREB3L2 |
Phospholipase D signaling pathway | PLA2G4C;AKT2;LPAR5;GAB2;INS;PIK3R1;KIT;PRKCA;MAPK3 |
Adrenergic signaling in cardiomyocytes | CALM3A;CAMK2D;AGTR1A;PPP2R5D;CACNG7;PIK3R3B;BCL2;ATP2B1;CALM1A |
Vascular smooth muscle contraction | RHOAC;PRKCG;PLA2G10;ARAF;PRKACBA;MAP2K2A;PPP1CB;PRKCD;PRKCE |
Gap junction | MAP2K2;GRB2A;HRASB;TUBA3D;TUBA1B;CX35B;TUBB6;GJA1;GNA15.1 |
Platelet activation | PLCG2;STIM1;ROCK1;PIK3CD;FYN;FCER1G;PRKG1;PLCB3;PRKACA |
Circadian entrainment | CALM1;NOS1AP;AKR1C1;PLCB3;FOS;GRIA1;GRIN1;PRKG1;MAPK3 |
Glutamatergic synapse | GLS2;PRKCG;GRIK2;GRIK4;PRKACG;GRIK5;SLC17A7;PLCB2;PRKACB |
Serotonergic synapse | PRKCA;GNGT2;ALOX12B;PLA2G4A;ITPR1;PLCB1;GNG12;Casp3;KCNN2 |
Dopaminergic synapse | MAPK8;PRKACB;CAMK2G;PPP1CC;GNAI1;PPP2CA;PPP2R2A;ARRB2;AKT2 |
Long-term depression | PLCB4;PLCB2;GRIA2;KRAS;GNAZ;PPP1R17;GRIA1;RAF1;NOS1 |
Taste transduction | TAS2R110;TRPM5;TAS2R113;GNAT3;TAS1R2;TAS2R126;TAS2R138;TAS2R109;TAS2R130 |
Inflammatory mediator regulation of TRP channels | TRPV2;CYP4A14;CAMK2G;PRKACB;CALM4;PLCG1;CYP2C55;MAPK12;CYP2C50 |
Insulin secretion | GNAS;ATP1B2;PCLO;ATP1B1;ATP1A3;KCNMB4;Adcy4;ATF4;CAMK2D |
GnRH signaling pathway | PRKCA;ELK1;PLCB4;ADCY1A;CDC42L;MAPK1;MAPK14A;MMP14B;MAPK3 |
Ovarian steroidogenesis | PRKACA;HSD17B2;PRKACB;ALOX5;PLA2G4A;PLA2G4C;PRKACG;HSD3B5;Adcy4 |
Estrogen signaling pathway | KCNJ3;RAF1;Adcy4;HSPA1A;PRKACA;GNAI3;HSPA8;GNAQ;GRB2 |
Melanogenesis | CREB3L3A;CALM2A;MAP2K2;MITFB;TCF7L2;PLCB2;KIT;CAMK2D2;WNT5A |
Thyroid hormone synthesis | ATP1B1;PAX8;GPX1;HSPA5;PLCB3;GPX5;GSR;CREB3L2;GNAQ |
Oxytocin signaling pathway | CACNB3;KCNJ14;SRC;PIK3CA;PLCB4;NPR1;PLA2G4D;ROCK1;HRAS |
Regulation of lipolysis in adipocytes | PIK3R1;PIK3CG;PIK3R2;TSHB;TSHR;PRKG2;ABHD5;PIK3CB;AKT1 |
Renin secretion | AGTR1A;PLCB2;GNAI2;CLCA4;PLCB4;PDE1C;CALML5;REN;PRKG2 |
Aldosterone synthesis and secretion | ORAI1;AGTR1A;CYP21A2;MC2R;PLCB3;SCARB1;ADCY1;NR4A2;NETO2 |
Endocrine and other factor-regulated calcium reabsorption | GNAQ;BDKRB2;KLK2;ATP2B1;KLK1B5;ATP1B1;KLK1B11;KLK1B9;PRKACB |
Salivary secretion | CAP18;CALM4;PRKG1;PRKACB;CALML5;ATP1A1;SLC9A1;PLCB2;AMY1B |
Gastric acid secretion | Adcy4;PRKACA;CAMK2G;EZR;SST;PLCB2;ATP1A3;KCNE2;ATP1A1 |
Pancreatic secretion | CLCA3;TPCN2;PRKCG;CELA3A;PRSS1;CLCA2;ATP2A2;GNAQ;CPB1 |
Bile secretion | SLC4A4;ABCB11;LDLR;SLC22A8;ADCY6;ATP1A1;SLC22A1;AQP4;SLC2A1 |
Cocaine addiction | SLC18A2;GRIN1;MAOA;CREB5;SLC18A1;GNAI3;NFKB1;DRD1;GNAI2 |
Alcoholism | HRAS;HIST1H4E;CALML5;H2AFZ;HIST2H3C2;HIST3H2A;HIST1H2BL;GNB4;H2AFX |
Vibrio cholerae infection | ATP6V0C;ACTB;ATP6V1G1;SEC61G;ACTG1;ATP6V0D2;ATP6V1B1;PLCG1;PRKACB |
Chagas disease (American trypanosomiasis) | PPP2R2C;IL1B2;PLCB1;AKT1;PPP2R2D;MYD88;FAS;IFNGR2;TLR2 |
Amoebiasis | C8A;SERPINB2;GNA11;RAB7A;GNAL;IL10;PRKACB;ARG1;SERPINB1A |
Pathways in cancer | RBX1;PIK3CD;PIK3R2;MAPK9;ITGAV;PIK3CG;LPAR3;NTRK1;BIRC3 |
Dilated cardiomyopathy | PLN;SLC8A1;TNNI3;RYR2;ITGA8;TNF;ITGB4;CACNA2D2;CACNG2 |
Gnas has several biochemical functions, for example, D1 dopamine receptor binding, G-protein beta/gamma-subunit complex binding, GTP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Gnas itself. We selected most functions Gnas had, and list some proteins which have the same functions with Gnas. You can find most of the proteins on our site.
Function | Related Protein |
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D1 dopamine receptor binding | ATP1A3;PTPN11;DRD3;GNAS;AGTR1A;CAV2;DLG4;ARRB2 |
G-protein beta/gamma-subunit complex binding | GNAO1;GNA11;GNAV1;GNA12;GNAO1A;GNA13;Adcy4;GNA15;GNAI2B |
GTP binding | ARHGAP5;ATL3;RAB11BA;RAP1AB;ARL5B;RHOAB;MTG1;RAP1AA;MX2 |
GTPase activity | TUBA2;GNGT2;RAP1B;RRAGC;GNAI3;ARL8B;TUBG2;DNM3A;MFN1B |
adenylate cyclase activity | ADCY3;ADCY6;ADCY1B;ADCY1;ADCY8;ADCY9;Adcy4;ADCY7;ADCY1A |
beta-2 adrenergic receptor binding | BDKRB2;SLC9A3R1;PDE4D;GNAS;NEDD4 |
corticotropin-releasing hormone receptor 1 binding | GNAS;GNAO1B;GNAO1A;UCN;GNAO1;CRH |
insulin-like growth factor receptor binding | REN;INS;INS2;IGF2A;Ren1;IGF3;GNAS;SOCS1;INSL4 |
ionotropic glutamate receptor binding | DLG2;SHANK1;SHANK2;DLG4;RAB4A;CACNG2;ADRB2;DLG4B;DLG1 |
metal ion binding | ZNF74;TNNI3;CA15B;CHAMP1;CLCA1;GNAQ;ZUFSP;ATP12A;KARS |
molecular_function | GM1673;TLK1;VWDE;C8orf42;DEFB11;CCDC57;TRANK1;TIFAB;GPM6B |
mu-type opioid receptor binding | GNAS;GPR177;GNAO1A;FLNA;GNAO1B;GNAO1;WLS |
protein binding | COMMD5;CDK10;TIMM8A;GPR37;HYPK;FGF12;TBX15;PSMD7;HYLS1 |
signal transducer activity | MAPKAPK5;VIPR1B;OMP;GNRHR1;OLFR78;ADCYAP1R1A;LGALS9;APLNRB;STAT5B |
Gnas has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Gnas here. Most of them are supplied by our site. Hope this information will be useful for your research of Gnas.
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