grhl1
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  • Official Full Name
  • grainyhead-like 1 (Drosophila)
  • Background
  • This gene encodes a member of the grainyhead family of transcription factors. The encoded protein can exist as a homodimer or can form heterodimers with sister-of-mammalian grainyhead or brother-of-mammalian grainyhead. This protein functions as a transcription factor during development. [provided by RefSeq, Jun 2009]
  • Synonyms
  • GRHL1; grainyhead-like 1 (Drosophila); MGR; NH32; LBP32; TFCP2L2; grainyhead-like protein 1 homolog; LBP protein 32; mammalian grainyhead; transcription factor LBP-32; transcription factor CP2-like 2;
Cat.#:GRHL1-5325HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GRHL1 Protein, GST-tagged
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Cat.#:GRHL1-7253MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GRHL1 Protein
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Cat.#:GRHL1-5751HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GRHL1 293 Cell Lysate
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Involved Pathway

GRHL1 involved in several pathways and played different roles in them. We selected most pathways GRHL1 participated on our site, such as Fatty acid, triacylglycerol, and ketone body metabolism, Metabolism, Metabolism of lipids and lipoproteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRHL1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Fatty acid, triacylglycerol, and ketone body metabolism
MED18; THEM5; ABCA1; ACSF3; CTGF; MED26; TMEM195; DGAT1B; ACOT2; ELOVL1A
Metabolism
GRHL1; CYP4F11; AZIN1; DTYMK; SLC25A15A; HS3ST4; SLC25A21; DPEP2; CKMT1B; FTCD
Metabolism of lipids and lipoproteins
CLPS; FABP1B.1; MED26; PTGDSA; ACOT8; GGTLC1; DHCR7; FA2H; PITPNB; YY2
PPARA activates gene expression
GRHL1; MED26; CTGF; PLIN2; MED19; CDK19; MED22; APOA5; G0S2; MED23
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
MED7; MED22; MED26; MED20; G0S2; MED29; MED23; MED31; MED9; MED25

Protein Function

GRHL1 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, chromatin DNA binding, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRHL1 itself. We selected most functions GRHL1 had, and list some proteins which have the same functions with GRHL1. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein HOXA2; NR5A2; NCOA2; FUBP3; FOXJ2; OTX1; NPAS4; NKX6; DDN; ZIC3
Function chromatin DNA binding
Related Protein PER1; ZIC2; GRHL1; MYOD1; THRB; RELA; VAX2; RUVBL2; H2AFY; H2AFY2
Function sequence-specific DNA binding
Related Protein SNAI2; NKX2-5; HOXB1A; MEOX2B; GSX1; DBX1B; PPARGC1A; MYBBP1A; IRX4; HSFY1
Function transcription regulatory region DNA binding
Related Protein KLF17; TBX16; SREBF1; WNT11; DHX36; SALL3B; ZFP382; SOX17; TP63; SALL4
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein NR4A1; NFIC; EPAS1; ELK3; RBPJ; FIGLA; FOXL2; PLAG1; RFX4; FOXC2

Interacting Protein

GRHL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRHL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRHL1.
Erp44

GRHL1 Related Articles

Kohn, KW; Zeeberg, BM; et al. Gene Expression Correlations in Human Cancer Cell Lines Define Molecular Interaction Networks for Epithelial Phenotype. PLOS ONE 9:-(2014).
Fabian, J; Lodrini, M; et al. GRHL1 Acts as Tumor Suppressor in Neuroblastoma and Is Negatively Regulated by MYCN and HDAC3. CANCER RESEARCH 74:2604-2616(2014).