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GRHL2

Official Full Name

grainyhead-like 2 (Drosophila)
Overview

The protein encoded by this gene is a transcription factor that can act as a homodimer or as a heterodimer with either GRHL1 or GRHL3. Defects in this gene are a cause of non-syndromic sensorineural deafness autosomal dominant type 28 (DFNA28).
Synonyms

GRHL2; grainyhead-like 2 (Drosophila); deafness, autosomal dominant 28 , DFNA28, TFCP2L3, transcription factor CP2 like 3; grainyhead-like protein 2 homolog; BOM; FLJ13782; DFNA28; FLJ11172; MGC149294; TFCP2L3; Brother of mammalian grainyhead; Deafness autosomal dominant 28; Grainyhead like 2 (Drosophila); Grainyhead like 2; Grainyhead like protein 2 homolog; GRHL 2; MGC149295; Transcription factor CP2 like 3; transcription factor CP2-like 3;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
DDK
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GRHL2-5750HCL	Recombinant Human GRHL2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	GRHL2-5326H	Recombinant Human GRHL2 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	GRHL2-5612HF	Recombinant Full Length Human GRHL2 Protein, GST-tagged	In Vitro Cell Free System	GST	625 amino acids	Inquiry
Human	GRHL2-4285H	Recombinant Human GRHL2 protein, His-tagged	E.coli	His	1-625aa	Inquiry
Human	GRHL2-5327H	Recombinant Human GRHL2 Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Mouse	GRHL2-7254M	Recombinant Mouse GRHL2 Protein	Mammalian Cell	His		Inquiry
Mouse	Grhl2-3305M	Recombinant Mouse Grhl2 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	GRHL2-3921M	Recombinant Mouse GRHL2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	GRHL2-3921M-B	Recombinant Mouse GRHL2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
GRHL2 Related Articles

GRHL2 involved in several pathways and played different roles in them. We selected most pathways GRHL2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with GRHL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

GRHL2 has several biochemical functions, for example, chromatin DNA binding, intronic transcription regulatory region sequence-specific DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRHL2 itself. We selected most functions GRHL2 had, and list some proteins which have the same functions with GRHL2. You can find most of the proteins on our site.

Function	Related Protein
chromatin DNA binding	GATA1;XBP1;NKAP;CLOCK;MED1;H2AFY2;RELA;HIST1H1B;RXRA
intronic transcription regulatory region sequence-specific DNA binding	BCL6;NKX2-1;GRHL2
protein binding	FBXO5;SMC2;BCL2L13;NSF;CLPTM1;NME2;SEMA6A;NSUN4;SPTBN1
sequence-specific DNA binding	CALCOCO1;MAFF;HNF1B;MAEL;IRX1B;RORAA;BCL11AA;PHOX2BB;FOXE1
transcription factor activity, sequence-specific DNA binding	FOXP4;SOX9;ZNF548;ZNF182;ZNF323;NFYAL;SCMH1;ZFP354C;MAFG
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	OSR2;BARHL1B;RFX6;GLIS1;ATF5;REST;ESRRG;IKZF3;STAG1

GRHL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRHL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRHL2.

LMO4

Tanimizu, N; Kobayashi, S; et al. Downregulation of miR122 by grainyhead-like 2 restricts the hepatocytic differentiation potential of adult liver progenitor cells. DEVELOPMENT 141:4448-4456(2014).

Singh, B; Shamsnia, A; et al. Highly Adaptable Triple-Negative Breast Cancer Cells as a Functional Model for Testing Anticancer Agents. PLOS ONE 9:-(2014).