GRIA2
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Official Full Name
glutamate receptor, ionotropic, AMPA 2
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Overview
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
GRIA2; glutamate receptor, ionotropic, AMPA 2; GLUR2; GLURB; GluA2; HBGR2; GluR-K2; glutamate receptor 2; gluR-2; gluR-B; AMPA-selective glutamate receptor 2;
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- Protein Conjugation
- His
- His (Fc)
- Avi
- His|T7
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- Involved Pathway
- Protein Function
- Interacting Protein
- GRIA2 Related Articles
GRIA2 involved in several pathways and played different roles in them. We selected most pathways GRIA2 participated on our site, such as cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRIA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cAMP signaling pathway | MAPK8;CAMK2A;PPP1CC;PRKACG;PDE4D;ATP1B2;CALML5;PPP1R12A;HTR4 |
| Neuroactive ligand-receptor interaction | HTR2C;PTGIR;TACR3L;VIPR2;HTR1E;RXFP1;GRIK4;TAAR13B;CGNRH-R |
| Circadian entrainment | PRKCG;CACNA1G;MTNR1A;GRIN1;GNG4;GNB1;CALM4;PLCB1;NOS1 |
| Long-term potentiation | PPP1CC;MAP2K2;RPS6KA1;HRAS;CAMK2B;GRM5;GRIN1;ARAF;MAPK3 |
| Retrograde endocannabinoid signaling | SLC17A7;PLCB2;PRKCA;GNG7;PLCB4;GABRG3;GNG11;GABRP;PRKACG |
| Glutamatergic synapse | PLCB3;PLA2G4C;TRPC1;GNG2;GNAI3;GRM1;GRIA2;GRIK3;SLC17A8 |
| Dopaminergic synapse | GNG8;PPP2R5A;ITPR3;PPP2R2A;SLC18A1;GNAI3;ATF6B;GSK3A;PLCB1 |
| Long-term depression | PPP2CB;GNAO1;PLCB2;PLA2G4F;RAF1;PLA2G4A;LYN;PLA2G4D;GRID2 |
| Amyotrophic lateral sclerosis (ALS) | MAPK13;PPP3CB;GRIA2;GPX1;CASP12;TOMM40L;CASP1;BAD;GRIN2A |
| Cocaine addiction | GNAI1;DLG4;PRKACG;GRIN3A;GRIN2A;GRIN2C;GRIN3B;DRD1A;CREB3 |
| Nicotine addiction | GRIN2B;GABRR1;GRIA3;GABRA2;GRIN1;GRIN3A;GABRR3;GABRD;SLC17A6 |
GRIA2 has several biochemical functions, for example, AMPA glutamate receptor activity, extracellular-glutamate-gated ion channel activity, ionotropic glutamate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRIA2 itself. We selected most functions GRIA2 had, and list some proteins which have the same functions with GRIA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| AMPA glutamate receptor activity | GRIA1;GRIA2A;GRIA4A;GRIA1A;GRIA1B;GRIA2B;GRIA4B;GRIA3B;GRIA3A |
| extracellular-glutamate-gated ion channel activity | GRIN1B;GRIA3;GRID1;GRIA3A;GRIN3B;GRIA1B;GRIA2;GRIK3;GRIN2D |
| ionotropic glutamate receptor activity | GRIA2B;GRIN1B;GRIN3B;GRIA3A;GRIA1B;GRIA4;GRIA2A;GRIA1A;GRID2 |
| protein binding | POLR1B;HBB;CELF1;BCKDK;PRKG1;TPCN2;RYR1B;WDR24;ERGIC2 |
GRIA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRIA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRIA2.
NSF; GTF3C2; NCOA4; ECD; NDUFV3; TXNL4A; KCNAB2; ATP5F1; DPP9; POM121; TSPYL2; TRMT6
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Q&As (5)
Ask a questionThere is a growing interest in targeting GRIA2 protein for drug development in schizophrenia, as it may help to address the underlying synaptic dysfunction in the disorder.
Research suggests that targeting GRIA2 protein could be a promising approach for developing new treatments for Alzheimer's disease.
Yes, genetic variations in the GRIA2 gene have been linked to an increased risk of developing certain neurological disorders.
GRIA2 protein plays a role in regulating the influx of calcium ions into neurons, and its dysfunction can lead to excitotoxicity, which is implicated in neurodegenerative diseases.
GRIA2 protein is involved in regulating the strength of synaptic connections, which is essential for synaptic plasticity and learning.
Customer Reviews (3)
Write a reviewthe GRIA2 protein has proven to be a valuable asset in protein electron microscopy structure analysis.
By utilizing the GRIA2 protein, researchers can unravel the intricate three-dimensional architecture of proteins, furthering our understanding of their function and facilitating the development of novel therapeutic interventions.
Scientists can confidently rely on the GRIA2 protein's exceptional attributes to generate accurate and biologically relevant data for their research.
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