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GRID2

  • Official Full Name

    glutamate receptor, ionotropic, delta 2

  • Overview

    Human glutamate receptor delta-2 (GRID2) is a relatively new member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain.GRID2 is a predicted 1,007 amino acid protein that shares 97% identity with the mouse homolog which is expressed selectively in cerebellar Purkinje cells.A point mutation in mouse GRID2, associated with the phenotype named lurcher, in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis.This strongly suggests a role for GRID2 in neuronal apoptotic death.
  • Synonyms

    GRID2; glutamate receptor, ionotropic, delta 2; glutamate receptor delta-2 subunit; GluR delta 2; GLUR D2; GLURD 2; GLURD2; Glutamate receptor delta 2 subunit; Glutamate receptor ionotropic delta 2; GRID 2; MGC117022; MGC117023; MGC117024; GluR-delta-2; OTTHUMP00000161600; OTTHUMP00000219270; gluR delta-2 subunit;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GRID2-13530H Recombinant Human GRID2, His-tagged E.coli His 20-358a.a.
Human GRID2-5335H Recombinant Human GRID2 Protein, GST-tagged Wheat Germ GST
Mouse GRID2-7261M Recombinant Mouse GRID2 Protein Mammalian Cell His
Mouse GRID2-3925M-B Recombinant Mouse GRID2 Protein Pre-coupled Magnetic Beads HEK293
Mouse GRID2-3925M Recombinant Mouse GRID2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat GRID2-2693R Recombinant Rat GRID2 Protein Mammalian Cell His
Rat GRID2-2347R-B Recombinant Rat GRID2 Protein Pre-coupled Magnetic Beads HEK293
Rat GRID2-2347R Recombinant Rat GRID2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish GRID2-1232Z Recombinant Zebrafish GRID2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

GRID2 involved in several pathways and played different roles in them. We selected most pathways GRID2 participated on our site, such as Neuroactive ligand-receptor interaction, Long-term depression, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRID2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Neuroactive ligand-receptor interactionGRIA3;GLP2R;NPBWR1;HRH4;PTGER4;MTNR1A;PTH2R;KISS1RA;AVPR1B
Long-term depressionBRAF;LYN;RYR1;PLCB2;MAP2K2;GNA13;PLCB3;PRKCB;PLA2G4A

GRID2 has several biochemical functions, for example, PDZ domain binding, extracellular-glutamate-gated ion channel activity, glutamate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRID2 itself. We selected most functions GRID2 had, and list some proteins which have the same functions with GRID2. You can find most of the proteins on our site.

Function Related Protein
PDZ domain bindingGIPC1;GRIK2;GRASP;SLC26A6;ATP2B3A;ATP2B1B;DLG1;ACVR2A;CADM1
extracellular-glutamate-gated ion channel activityGRID1;GRIK5;GRIN3A;GRIA2B;GRIN1B;GRIN3B;GRIA2A;GRIN1A;GRID2
glutamate receptor activityGRM8;GRM5;GRM2;GRIK3;GRM6;GRID2;GRM4;GRM1;GRIK5
ionotropic glutamate receptor activityGRIA1B;GRIN2BB;GRIK3;GRIA4;GRIA4B;KBP;GRIA2B;GRIN2A;GRIA2A
scaffold protein bindingSRC;KCNQ1;NLRP1;DLG4;NOS3;NCK2;KRT15;HOMER1;ATP2B4

GRID2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRID2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRID2.

Magi2

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